What is PAGE?

We represent a community with a shared interest in data analysis using the population approach.

Xpose 4
is a model building aid for population analysis using NONMEM®. Xpose produces various plots and analyses to facilitate data set checkout, goodness-of-fit analysis, model exploration and visualization, model diagnostics, candidate covariate identification and model comparison.  Xpose 4 is written in the programming language R and allows for integration into nearly any model building platform. New functionality in Xpose 4 allows the user to create simulation based reference diagnostics, compute the conditional weighted residuals and modify standard Xpose graphics to create publication quality figures.
Perl-speaks-NONMEM (PsN)
is a collection of Perl modules and programs aiding in the development of non-linear mixed effect models using NONMEM®. The functionality ranges from simpler tasks such as parameter estimate extraction from output files, data file sub setting and resampling, to advanced computer-intensive statistical methods. PsN includes both stand-alone tools as well as development libraries for method developers.
Metrum Research Group Open-Science: Tools, Courses, and Models
Metrum Research Group (MetrumRG), is a proponent of open-source software development efforts. Many of the tools we’ve developed for our own work are available as free, open-source software under GPL. See this link for more information. MetrumRG also participates in training and education through various industry and academic M&S research efforts.
Wings for NONMEM
WFN is a set of DOS batch command files and awk scripts to help NONMEM® users be more productive. The first version of WFN (Wheels for NONMEM) was written in 1989 at UC San Francisco. The unix csh and awk scripts evolved and were eventually ported to DOS in order to support NONMEM as part of the RIDO (Right Dose First Time) project.
Census 2
is a comprehensive project manager for NONMEM, providing detailed summary, comparison and overview of the runs comprising a given project, including the display of output data and post-run processing. The new version is a complete rewrite of Census from the ground up. In addition to adding cross-platform support, Census 2 incorporates a number of interface changes, including flexible run tagging and filtering, report output in HTML and LaTeX, a portable database file format, full support for NONMEM 7.2 (including support for multiple estimation steps), and too many others to mention.
Simulo by SGS Exprimo
is a software for PK-PD-Disease model simulations and subsequent post-processing of simulation results. It has a user-friendly interface but can specify any pharmacometric model, very complex study designs and dosing schedules (adaptive trials, interim analysis, dose adaptation based on drug response, adverse events) in an extremely flexible way, as the simulation uses an R backend. The resulting R-script may be applied outside of Simulo in any R environment.
Pirana
is a modeling environment for NONMEM and PsN, and provides an easy-to-use toolkit for both novice and advanced modelers. Pirana can be used to run, manage and edit models, interpret output, and manage NONMEM installations. It supports modeling on a local system and on computer clusters, and is easily extendible with custom scripts, and integrates smoothly with R, Xpose, Excel and other software. Pirana supports all NONMEM versions and runs on Windows, Linux and Mac OSX. Pirana is free for academic use, the purchase of a commercial license is required for use in industry and consulting. 
PFIM
is a collection of R functions for population designs evaluation and optimisation. It is based on the expression of the Fisher information matrix in nonlinear mixed effects models. The recent versions are PFIM Interface 2.1, for single response models which includes a graphical user interface, and PFIM 3.0 for multiple response models. Several new features are proposed. A library of usual PK models is available and other models can be written using an analytical form or using a differential equations system. Regarding optimisation, it can be performed using either the Simplex algorithm or the Fedorov-Wynn algorithm.
WinPOPT
is standalone software for the optimal design of population PK and PKPD studies. The software runs on a Windows platform either as standalone or over a network. WinPOPT contains a library of PK models and offers flexibility in the input of user-defined models. Design and technical support are available.
Simcyp (A Certara Company)
is a simulation and data analysis tool for PB-PK-PD applications associated with small and large therapeutic molecules. It offers a database with multiple system parameters related to physiology, biology, genetics and anatomy for specific disease groups and defined age bands in humans and experimental animals. Simcyp is widely used by over 25 leading pharmaceutical companies for model-based drug development; from discovery to late clinical phases. All simulations are stochastic; however either individual or POPPK analyses can be applied for fitting data. The user-friendly interface is designed to facilitate access of various levels of expertise in nonlinear mixed effects approaches.
Open Systems Pharmacology Suite (OSPS with PK-Sim® and MoBi®)
is a free open-source software for whole-body physiologically-based pharmacokinetic (PBPK) and Quantitative Systems Pharmacology (QSP) modeling and simulation. The best-known tools of the suite are PK-Sim and MoBi, which allow development of sophisticated PBPK QSP models in an intuitive graphical user interface. The software comes with an extensive database of physiology (human and pre-clinical) and protein expression, allowing model creation across the whole pharmaceutical life-cycle, from pre-clinical PK to human trial simulation. Thanks to its open-source nature, the OSPS is supported by a growing community of industry and academia. For more info and to download the software, please visit: www.open-systems-pharmacology.org
NIMROD
is a Fortran program  (Normal approximation Inference in Models with Random effects based on Ordinary Differential equations) devoted to the estimation in Ordinary Differential Equations (ODE) models with random effects. Although maximum likelihood based approaches are valuable options, both numerical and identifiability issues favor a Bayesian approach which can incorporate prior knowledge in a flexible way. NIMROD estimations relies on a normal approximation of the posterior that can be obtained by computing the maximum of the posterior distribution (MAP) by maximizing a penalized likelihood. NIMROD can be downloaded freely together with libraries for Pharmacokinetics and HIV models. 
PopED
computes optimal experimental designs for both population and individual studies based on nonlinear mixed-effect models. Often this is based on a computation of the Fisher Information Matrix. PopED is written in R and is available as a package via CRAN.
Simulations Plus, Inc. (NASDAQ: SLP)
is the premier developer of modeling & simulation software and consulting services supporting drug discovery, development research and regulatory submissions. We partner with companies to provide a data-driven, strategic modeling methodology, starting in early discovery, continuing through preclinical/clinical development, and concluding with clinical trials/post approval. With our subsidiaries, Cognigen Corporation and DILIsym Services, we offer #1-ranked, easy-to-use software (GastroPlus™, ADMET Predictor™, KIWI™, DILIsym®, NAFLDsym®, PKPlus™, and more) to bridge data mining, compound library screening with QSAR models, PBPK/TK modeling & simulation in animals and humans following administration around the body, and quantitative systems pharmacology approaches. Simulations Plus technology is licensed to and used by regulatory agencies worldwide. For over 20 years, Simulations Plus has partnered with our clients to reduce costs and accelerate research and development productivity by improving the ways scientists use knowledge and data to predict the properties and outcomes of pharmaceutical & biotechnology agents. Simulations Plus’ team of over 80 dedicated scientists & professionals, with decades of experience, stands ready to help.
IQR Tools
is an R package that allows for seamless and efficient modeling across systems biology, systems pharmacology and pharmacometrics. It interfaces NONMEM, MONOLIX, and NLMIXR, enabling the user to fluently switch between parameter estimation platforms. In addition, it provides a world-leading powerful estimation method for systems pharmacology type of modeling, non-compartmental analysis functionality, and seamlessly interfaces with optimal experiment design R packages.
IQReport
is the innovative solution for reproducible research and efficient reporting in Microsoft Word. It allows writing of reports in a powerful extended markdown language and the final Word documents can match any desired corporate Word style through the use of customized reporting templates. With a shallow learning curve and user-friendly interface, IQReport speeds up the report writing process and allows for more time to focus on science and interpretation of the results.

Please send comments to Rik Schoemaker (rs@page-meeting.org)

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