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Lewis Sheiner


2018
Montreux, Switzerland
 Organisers



2017
Budapest, Hungary

2016
Lisboa, Portugal

2015
Hersonissos, Crete, Greece

2014
Alicante, Spain

2013
Glasgow, Scotland

2012
Venice, Italy

2011
Athens, Greece

2010
Berlin, Germany

2009
St. Petersburg, Russia

2008
Marseille, France

2007
KÝbenhavn, Denmark

2006
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2005
Pamplona, Spain

2004
Uppsala, Sweden

2003
Verona, Italy

2002
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2001
Basel, Switzerland

2000
Salamanca, Spain

1999
Saintes, France

1998
Wuppertal, Germany

1997
Glasgow, Scotland

1996
Sandwich, UK

1995
Frankfurt, Germany

1994
Greenford, UK

1993
Paris, France

1992
Basel, Switzerland

Printable version

2018
   Montreux, Switzerland

Twenty-seventh meeting, 29 May - 1 June, 2018

The PAGE 2018 meeting will be held at 2m2c Congress Center, Montreux, Switzerland.

 

Montreux by the lake

Image credits ©Montreux Riviera Tourisme

Conference location

The PAGE meeting takes place in an informal atmosphere with vivid scientific discussion. PAGE 2018 will be held at the Montreux Music & Convention Center. The meeting starts with a welcome reception at “Marché couvert” (Covered market) in Montreux city center on Tuesday evening 29 May. The scientific programme will start on Wednesday morning 30 May and will end at noon on Friday 1 June. Participants are encouraged to attend all conference days and present their work in the form of an oral presentation or poster.

Abstracts and Apps

The program and abstracts will be available half April as a single document for download. Note that no printed abstracts are available at the conference so print them at home or use the special Apps that have been developed for iPhone and Android to view all abstracts off-line on your portable device.

Programme items:

  • The Lewis Sheiner Student Session
    The annual Lewis Sheiner Student Session was inaugurated, both to honour the memory of Lewis Sheiner and to highlight his lifetime passion for student education. Students who wish to be considered for this session should submit an extended abstract no later than 26 February 2018.
    • The abstract must be structured with the following subheadings: Objectives / Methods / Results / Conclusion / References.
    • There must be at least 6,000 but not more than 7,000 characters (including spaces) in the abstract text(excluding Title / Authors/ Affiliation and References).
    • The submitted work must have been performed either as part of an MSc or PhD programme and/or will ultimately form part of a PhD thesis.
    • Each year a rotating committee of three members, representative of the PAGE community, will judge who should receive the honour of presenting in the Lewis Sheiner Student Session.
    • If selected, the student will automatically receive a 300 euro travel grant. A permanent list of students, with links to their presentation, will be maintained on the web site.
  • The Stuart Beal Methodology Session
    As a tribute to Stuart Beal, the organising committee has instituted the Stuart Beal Methodology Session. The organising committee will choose presenters from the submitted abstracts.
  • Special session on Pharmacometrics in dose individualisation – focus on biomarkers. This session will be focused on the combined utilisation of TDM biomarker data and model-based methods in dose individualization. Further presenters will be selected by the organising committee from the submitted abstracts.
    • Dr Thierry Buclin (University Hospital of Lausanne) will give an introduction to the theme and emphasize the clinicians’ needs when facing TDM results.
    • Dr Catherine Sherwin (University of Utah) will share her experience in dose individualization approaches using biomarkers.
  • Special session on Immunotherapy in oncology. This session will cover a clinical overview and modelling aspects in this area. Speakers TBD, and further presenters will be selected by the organising committee from the submitted abstracts. 
  • Special session on Estimands. The purpose of this session is to give a background to Estimands and the potential opportunities from a pharmacometric perspective. The session will encompass the statistical and the pharmacometric viewpoints. Speakers TBD.

Registration

  • Registration will open on Monday 15 January at 9:00 (9AM) local Swiss time (CET, Central European Time: GMT+2 in summer). Registration is only possible at the PAGE website.
  • If you have previously registered at the PAGE website, your personal details (address etc.) are still available.
  • If this is the first time you will attend PAGE, register first at the PAGE website before enrolling for the meeting.

Please keep our database up to date by editing your existing profile if required!

  • If you've forgotten your password, a reminder can be requested automatically from the website by e-mail.
  • If you've forgotten your password and changed your e-mail address then please contact Rik Schoemaker (rs@page-meeting.org).
  • Updates of personal details in the website are confirmed automatically by email. Note that if you do not receive a confirmation, you should check that your e-mail address is correctly entered in the designated field.

Registration fees and payment

  • Registration fees are:
    • 625 € for participants from industry and commercial enterprises
    • 425 € for academics (including post-doc students), non-profit participants, unemployed or retired professionals, and government employees
    • 125 € for full time students in an MSc or PhD programme at the time of the PAGE meeting (and not otherwise employed) who do not submit and present a poster or oral communication abstract at PAGE 2018
    • 25 € for full time students in an MSc or PhD programme at the time of the PAGE meeting (and not otherwise employed) who do submit and present a poster or oral communication abstract at PAGE 2018
  • Fees include coffee, tea and lunch on all days, the welcome reception on 29 May and the social event on 31 May.
  • Accompanying persons may attend the welcome reception and the social event for a fee of 125 €
  • Participant places are limited and allocated on a first come, first serve basis.
  • Registration fees must be paid at the PAGE website by credit card only (Visa, Maestro, MasterCard and American Express) within 14 days after registering at the PAGE website. Visa payments require Verified-by-Visa to be activated, and MasterCard requires SecureCode for your and our own security. Failure to meet this deadline will automatically place your registration on the waiting list.
  • Students wishing to qualify for the student registration fee will need to upload, at the time of registration, a scanned copy of a signed letter of support from their supervisor indicating that they will be full time students in an MSc or PhD programme at the time of the PAGE meeting, and a scan of their current student card. If this information (and an abstract if applicable) is not available at the time of the abstract deadline (26 February), non-reduced fees will be charged.

Cancellation policy

No refunds will be given once the registration fee has been paid, not even in the extremely unlikely event that the meeting is cancelled due to force majeure. Substitution of delegates will be accepted at any time.

PAGE Student Sponsorship

A PAGE Student Sponsorship to support travel and accommodation expenses (kindly supported by Certara, ISoP, BAST, and Occams), is available to a number of students unable to obtain any other financial support. This will be judged on a case-by-case basis by a selection committee. Please see here to download a form with criteria and details on how to apply. Applications need to be submitted by the time of the abstract deadline (26 February), so make sure you receive confirmation of receipt when sending your application.

Abstract submission

Deadline for Lewis Sheiner Student Session abstracts: 26 FEBRUARY 2018
Deadline for regular abstracts: 26 FEBRUARY 2018

The abstract submission deadline is the same for all abstracts: Lewis Sheiner Student Session abstracts, oral session abstracts, and poster abstracts and there will be no option for late submissions. The reason is that the PAGE organising committee cares about the quality of all abstracts, and that means that sufficient time is required for judging the abstracts. In particular, abstracts without results will be rejected. Statements such as “…will be shown…”, or “…will be available at the time of the conference…” are not acceptable. Furthermore, abstracts for an anonymous drug (drug X) will not be accepted unless the work clearly describes a new methodology/new disease model for a specific therapeutic area (or similar), i.e. is of value to the pharmacometric community without the identity of the drug. Accordingly, a 2-compartment population PK model for drug X will not be acceptable. Also note that the abstract length (both minimum and maximum) has been increased significantly compared to previous years, to allow a better assessment of the intended presentation.

  • Please follow these instructions carefully regarding format and length of the abstracts or download them in either Word/RTF or Adobe/PDF format. Abstracts that do not comply with these guidelines will not be accepted.
  • Each participant is only allowed to submit one abstract, i.e. either in an oral or in a poster category
  • If your request for an oral presentation is not granted, you will be contacted to change your abstract category from an oral to a poster category
  • Submission of abstracts is only possible online through the PAGE website. Log in, click on 'Register/submit abstract' and click the link on the bottom of your personal info page.
  • To facilitate the review of abstracts and to help structure the poster sessions, please select an abstract category when you submit your abstract.
  • The abstract must be structured with the following headings: Objectives / Methods / Results / Conclusion / References.
  • There is a strict limit of 3,000 to 4,500 characters (including spaces) for the abstract text (excluding Title/ Authors/ Affiliation and References).
  • When you click "Submit" you will immediately receive an email with your abstract attached. This e-mail will also be sent to the committee responsible for peer review in the selected category. Therefore, only click "Submit" when you have finished editing!
  • Abstracts will remain invisible until release of the final programme (anticipated date: between 5 and 15 April).

Posters

The poster boards will accommodate an A0-size portrait poster (118.9 cm high and 84.1 cm wide/46.8 by 33.1 inches). Material for mounting your poster to the boards will be available on-site. 

The local organisers have provided the possibility of having your poster printed on-site at the cost of CHF 55 for paper quality and CHF 75 for fabric quality. Prepare your poster in A0 portrait layout in pdf format, and upload your file here. The deadline for file-submission and payment is May 18.

Software demonstrations

Software companies, Academic Software Application Developers and Contract Research Organisations are welcome to present their products and services during PAGE. The cost for one commercial table is 1700 euros including dedicated high speed wifi connection. Please visit the conference secretariat webpage for further details. 

SATELLITE MEETINGS

Several events will be held before and after the PAGE meeting. If you are interested in organising such a satellite meeting, please fill in the online form and the local organising agency Swiss Backstage will get in touch. Please note that PAGE itself is not involved in organising satellite workshops or booking venues, etc, and satellite meetings cannot be booked through the PAGE or local organisers web-site.

  • Simcyp Limited (a Certara company) is running a one-day Parameter Estimation and Pharmacodynamics (PE/PD) hands-on workshop on Tuesday 28 May. The workshop covers the concepts and application of combining the top-down and bottom-up approaches to build fit for purpose PBPK models and the further linking of PBPK models to PD models to provide insight into covariate effects through a combination of lectures and hands-on sessions. The major topics covered are:

    • Data entry, fitting and interpretation of results
    • Simultaneous fitting of PK and PD parameters
    • Covariate recognition
    • Using built-in and custom scripted pharmacodynamic models in Simcyp
    • PD driven by the concentration at the relevant site of action e.g. liver
    • Running the Simcyp Simulator through the R package.

    Cost: Academics £75.00, Simcyp Consortium members £75.00, and Non Members £150.00. To register please click here or email Kelly on events@simcyp.com

  • Simcyp Limited (a Certara company) is running a one-day hands-on workshop on Bridging PBPK with POPPK for Paediatrics on Tuesday 29 May. The workshop covers predicting the age-related changes to pharmacokinetics and drug-drug interactions including associated variability and linking this information to drug response in the preterm and full term paediatric population. Examples of “how this informs the design of POPPK studies” will be presented during the course. The major topics covered are:

    • Age-dependent physiological PK models for small molecules and large molecules
    • Prediction of drugs pharmacokinetics using IVIVE approach
    • Handling Age-varying covariates during simulation
    • Prediction of DDI in paediatrics
    • Linking PK variability to drug response in children
    • Strategies for optimal study design using combination of PBPK and POPPK

    Cost: Academics £75.00, Simcyp Consortium members £75.00, and Non Members £150.00. To register please click here or email Kelly on events@simcyp.com

  • Simcyp Limited (a Certara company) is running a one-day workshop on physiological modelling of therapeutic proteins and antibody-drug conjugates on Tuesday 29 May. The workshop will combine lectures and hands-on sessions and focuses on both the considerations needed to model the ADME and target binding properties of therapeutic proteins, mAbs, antibody drug conjugates, and bispecific antibodies in a systems pharmacology context, using minimal and full PBPK models, and model applications in drug development. The major topics covered are:

    • Physiological models of protein (subcutaneous) absorption and distribution
    • Clearance mechanisms of therapeutic proteins
    • Physiological models of Antibody Drug Conjugates
    • Modelling of target mediated drug disposition (TMDD) of protein and ADCs including techniques to account for target shedding and binding kinetics of bispecific antibodies.

    Cost: Academics £75.00, Simcyp Consortium members £75.00, and Non Members £150.00. To register please click here or email Kelly on events@simcyp.com

  • The nlmixr team will be running a one-day hands-on workshop on simulation and parameter estimation using the free and open-source R-based nonlinear mixed effect modelling platform nlmixr on Tuesday 29 May. The course will consist of a mixture of lectures and hands-on exercises. Contact info@nlmixr.org for further information and registration. Cost: 180 euro to cover the workshop room, lunch and coffee/tea. We have a limited number of reduced fee spaces available if you can argue a strong case.

ACCOMMODATION

Swiss Backstage, the official conference organizer, has secured a variety of hotels for the PAGE meeting, which range from standard to more luxurious accommodations at preferential rates. An overview of the hotel accommodation options can be obtained here, and a google map with all hotels can be found here. Montreux is a small town, rooms are limited and will be booked on a first-come first serve basis. We therefore kindly advise all the delegates to proceed with their bookings well in advance. Booking your hotel through this link in the Montreux area (including Montreux, Vevey, Territet, La-Tour-de-peilz, Villeneuve) will give the participants a Riviera Card: free publics tranportation for the full length of the stay and up to 50% discount on a wide range of museums and attractions.

Room reservation process
Should you wish to book your hotel online, please use this this link. For group reservations (over 5 rooms), please contact the Booking Secretariat directly at page2018@swissbackstage.com. A confirmation letter for your reservation will be sent automatically to your email account. Should you not receive a confirmation letter, please contact Swiss Backstage (see below). Rooms have been pre-booked in all the hotels until March 2nd 2018 and will be confirmed on a first-come first-served basis as they are subject to availability. After this date, all reservations will be handled upon request.

Payment and Cancellation policy

  • Payment will be secured by credit card
  • Cancellation free of charge until 72h before arrival (except when mentioned otherwise on the booking confirmation). Past this deadline and in case of no show, 100% of the reservation will be charged
  • Room reservations cut-off date: March 2nd, 2018

ABOUT MONTREUX

Also known as the Swiss Riviera thanks to its micro-climate, Montreux-Vevey has attracted people from all over the world at every time of the year. A wide range of overnight accommodations, romantic wine-villages, medieval castles and elegant “Belle Epoque” edifices attest to the great variety of the region. An international all-year program of festivals and culture as well as exceptional event locations make Montreux-Vevey an attractive destination for meetings.

The Montreux Riviera extends over an area of 225 km2 and a population of about 89'872 inhabitants. The main language spoken is French, however a majority of the population can speak English and German. The highlight of the Montreux Riviera are Les Rochers-de-Naye at 2’042m. The city of Montreux is located in a protected bay on Lake Leman, surrounded by vineyards, and in the breathtaking scenery of the snow-covered Alps. It is particularly famous for the Montreux Jazz Festival which takes place every year in June / July on different stages and in the parks of the city.

Thanks to its extraordinarily mild climate, Montreux deserves its name as the capital of the Vaud Riviera. The region is characterized by parasol pines, cypresses and palm trees that are more generally found around the Mediterranean basin. Charlie Chaplin, Freddie Mercury and many other world-famous personalities have lived or still live on the Vaud Riviera. A long flower walk along the lake leads from Vevey Montreux to Castle Chillon. Cultural events such as the Montreux Jazz Festival, as well as endless opportunities for mountainous hinterland or lake excursions make this city a popular destination for excursions and holidays. Many buildings from the golden age of the Belle Époque line the lake shore, including the sumptuous Fairmont Le Montreux Palace and the Montreux Music and Convention Center (2M2C).

Access to Montreux
From Geneva airport : 1h15 by train (every 30 min) or car.
From Zürich airport : 3h by train or 2h40 by car
From Basel airport : 3h by train or 2h20 by car
From Bern airport : 2h20 by train or 1h20 by car

Public transport in Montreux
Public transport in Montreux is provided by Transports publics de la Riviera Vaudoise (VMCV). Montreux has an efficient public transport network. Generally, buses and trolleybuses operate between 05.30 AM and midnight. PAGE participants staying at hotels in the Riviera (Vevey - La Tour-de-Peilz – Clarens – Montreux - Villeneuve) have free public transport. For maps and timetables, please visit the VMCV website (in French). Travelling by train is the easiest way to get around, please visit the CFF-SBB website.

Taxis in Montreux
Several taxi companies operate in Montreux. Prices are expensive depending on the route. Example: Vevey-Montreux CHF 30.00 / Villeneuve-Montreux CHF 24.00 / Lausanne-Montreux CHF 100.00.

Time
Switzerland is in the Central European Time Zone. In the summer months clocks are set at GMT + 2 hours.

Weather
The weather in Montreux in June is generally pleasant. Temperatures are usually in the range between 11 and 19 °C during the day. Check the weather forecast for Montreux here.

Foreign exchange, banking facilities
The official national Swiss currency is the Swiss Franc (CHF). All most major credit cards are accepted in Switzerland in places. Switzerland is not a member of the European Union but the stores accept euros but will return currency in CHF. You can change your money into all the major currencies (€, $, £, ¥, CAD, AUD, etc.) at banks (Monday to Friday), as well as in CFF stations (7 days a week). The major stations and banks provide automatic currency dispensers or changeomats that operate 24/7. In addition, it is possible to withdraw € from most cash dispensers in banks (bancomat/ATM) or Post Offices (postomat/ATM).

Tips
Service is included in all restaurants and shops. Tips are optional at the customer’s discretion.

Electricity
An adaptator is almost always required (unless you live in Switzerland): Ref. SEV 1011, 220 volts AC, 50 Hz

Shopping in Montreux (opening hours)
Major stores and specialist shops are open Monday to Friday from 8.30 am. to 6.30 PM or 7.00 PM, and on Saturdays until 5.00 or 6.00 PM. Shops are closed on Sundays, except for some bakers and grocers.

Emergency phone numbers
Ambulance: 144
Fire brigade: 118
Police: 117 

CONFERENCE SECRETARIAT

Swiss Backstage
Rue JJ Rousseau 4
1800 Vevey
Switzerland
Email: page2018@swissbackstage.com (monitored until May 25th)
Tel: +41 76 298 40 10
On-site tel: +41 21 613 73 14

For matters related to payment of registration fees:

Meeting Makers Ltd 
Tel: +44 (0) 141 945 6880 
Fax: +44 (0) 141 945 6899
page2018@meetingmakers.co.uk 

For matters related to abstracts:

info@page-meeting.org