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Lewis Sheiner

Stockholm, Sweden
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Tuesday 11 June


14:00-18:00 Registration at the Conference Venue
18:00-19:30 Welcome reception with drinks and light snacks (no dinner)


Wednesday 12 June


08:00-08:45 Registration
08:45-09:00 Welcome and Introduction
09:00-09:45 Keynote lecture

Chair: Dinesh De Alwis

09:00-09:45 Jeff Sachs Pharmacometrics: A shot in the arm for vaccine discovery and development ~or~ Vaccines are not immune to the charms of pharmacometrics
09:45-09:50 PAGE scientific program 

Siv Jönsson

09:50-11:15 Coffee break, Poster and Software session I
  Posters in Group I (with poster numbers starting with I-) are accompanied by their presenter
11:15-12:15 Infectious diseases

Chair: France Mentré

11:15-11:35 Marjorie Imperial Stratified medicine approaches for drug susceptible tuberculosis patients
11:35-11:55 Stefanie Hennig Repeated time-to-event models support that Pseudomonas aeruginosa infection increase the risk of acquiring Aspergillus in young children with cystic fibrosis
11:55-12:15 María García-Cremades Individual level data meta-analysis from HIV pre-exposure prophylaxis (PrEP) clinical trials
12:15-13:45 Lunch
13:45-14:30 Tutorial

Chair: Mats Karlsson

13:45-14:30 Nicky Best Use of informative priors in model-informed drug development 
14:30-15:10 Machine learning in oncology

Chairs: Mats Karlsson, Paolo Magni

14:30-14:50 Chiara Nicolò Machine learning combined to mechanistic modeling of differential effects of neoadjuvant sunitinib on primary tumor and metastatic growth
14:50-15:10 Sebastien Benzekry Machine learning versus mechanistic modeling for prediction of metastatic relapse in breast cancer
15:10-16:40 Tea break, Poster and Software session II
  Posters in Group II (with poster numbers starting with II-) are accompanied by their presenter
16:40-16:45 Clinical pharmacometrics - ISoP special interest group

Mirjam Trame and Eva Germovsek

16:45-17:25 Clinical applications

Chair: Oscar Della Pasqua

16:45-17:05 João Abrantes Bayesian forecasting utilizing bleeding information to support dose individualization of factor VIII
17:05-17:25 Belén Pérez Solans Model-based characterization of neutrophil dynamics in children receiving busulfan or treosulfan for hematopoietic stem cell transplant conditioning 
17:25-18:05 Rare (and other) diseases

Chair: Panos Macheras

17:25-17:45 Zinnia Parra-Guillen Disease pharmacokinetic-pharmacodynamic (PKPD) modelling to support the development of gene therapy treatments for rare diseases
17:45-18:05 Pascal Chanu A disease progression model for geographic atrophy


Thursday 13 June


08:30-09:50 Lewis Sheiner Student Session

Chair: Andrew Hooker, Emilie Hénin, Thomas Dorlo

08:30-08:55 Moustafa Mahmoud Abdellatif Ibrahim Competing risks analysis of the Finnish diabetes prevention study
08:55-09:20 Sebastiaan Goulooze Novel pharmacometric techniques to quantify and prevent iatrogenic withdrawal in children
09:20-09:45 Elena Tosca Dynamic Energy Budget (DEB) based models of tumor-in-host growth inhibition and cachexia onset
09:45-09:50 Presentation of Lewis Sheiner student session awards
09:50-09:55 Special announcement
09:55-11:20 Coffee break, Poster and Software session III
  Posters in Group III (with poster numbers starting with III-) are accompanied by their presenter
11:20-12:25 Regulatory model-informed drug discovery and development

Chair: Aris Dokoumetzidis

11:20-12:05 Kristin Karlsson and Flora Musuamba Tshinanu Regulatory model-informed drug discovery and development in EU – News flash and examples
12:05-12:25 Sylvie Retout A model-based extrapolation enabled labelling of emicizumab in haemophilia A paediatric patients
12:25-12:30 Announcement for ACoP10 2019

Mirjam Trame

12:30-14:00 Lunch
12:30-14:00 ISoP Student Community meet-and-greet during lunch
14:00-15:20 Stuart Beal methodology session

Chair: Emmanuelle Comets and Siv Jönsson

14:00-14:20 Theodoros Papathanasiou Model based optimization of dose-finding studies for drug-combinations
14:20-14:40 Antonio Goncalves Model averaging in viral dynamic models
14:40-15:00 Mohammed Cherkaoui Rbati A liver model for chemoprotection against malaria
15:00-15:20 Xiao Zhu A cohesive model framework of receptor pharmacology: beyond the Emax model
15:20-15:25 Announcement for WCoP 2020

15:25-16:50 Tea break, Poster and Software session IV
  Posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter
16:50-17:30 Stuart Beal methodology session, continued

Chair: Justin Wilkins

16:50-17:10 Alison Margolskee Exploratory graphics (xGx): promoting the purposeful exploration of PKPD data
17:10-17:30 Marc Cerou Performance of npde for the evaluation of joint model with time to event data
18:30-01:00 Social event


Friday 14 June


09:20-10:20 Oncology

Chair: Ana Ruiz, Siv Jönsson

09:20-09:40 Aurelia de Vries Schultink Prospective evaluation of therapeutic drug monitoring of endoxifen: feasibility of observational and randomized trials
09:40-10:00 Coralie Tardivon Association between tumor size kinetics and survival in advanced urothelial carcinoma patients treated with atezolizumab: implication for patient’s follow-up
10:00-10:20 Jiajie Yu A new approach to predict PFS in ovarian cancer based on tumor growth dynamics
10.20-10.25 Preview of PAGE 2020
10:25-11:00 Coffee break
11:00-11:40 Oncology, continued

Chair: Marylore Chenel

11:00-11:20 Julie Janssen A semi-physiological framework to predict changes in pharmacokinetics of cytotoxic drugs in pregnant women
11:20-11:40 James Lu Integrated efficacy-safety QSP model of acute myeloid leukemia (AML) generates insights into the role of clinical dose schedules on cytopenia
11.40-11.50 Closing remarks
11:50-12:10 Audience input for potential PAGE 2020 topics