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Tuesday
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| 14:00-18:00 |
Registration at the conference venue |
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| 18:00-19:30 |
Welcome reception with drinks and light snacks (no dinner) |
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Wednesday
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| 08:00-08:45 |
Registration at the conference venue |
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| 08:45-09:00 |
Welcome and introduction |
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| 09:00-09:45 |
Keynote lecture |
Chair: Dinesh De Alwis
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| 09:00-09:45 |
Jeff Sachs |
Pharmacometrics: A shot in the arm for vaccine discovery and development ~or~ Vaccines are not immune to the charms of pharmacometrics |
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| 09:45-09:50 |
PAGE scientific program |
Siv Jonsson
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| 09:50-11:15 |
Coffee break, poster and software session I: posters in Group I (with poster numbers starting with I-) are accompanied by their presenter |
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| 11:15-12:15 |
Infectious diseases |
Chair: France Mentré
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| 11:15-11:35 |
Marjorie Imperial |
Stratified medicine approaches for drug susceptible tuberculosis patients |
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| 11:35-11:55 |
Stefanie Hennig |
Repeated time-to-event models support that Pseudomonas aeruginosa infection increase the risk of acquiring Aspergillus in young children with cystic fibrosis |
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| 11:55-12:15 |
María García-Cremades |
Individual level data meta-analysis from HIV pre-exposure prophylaxis (PrEP) clinical trials |
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| 12:15-13:45 |
Lunch |
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| 13:45-14:30 |
Tutorial |
Chair: Mats Karlsson
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| 13:45-14:30 |
Nicky Best |
Use of informative priors in model-informed drug development |
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| 14:30-15:10 |
Machine learning in oncology |
Chairs: Mats Karlsson, Paolo Magni
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| 14:30-14:50 |
Chiara Nicolò |
Machine learning combined to mechanistic modeling of differential effects of neoadjuvant sunitinib on primary tumor and metastatic growth |
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| 14:50-15:10 |
Sebastien Benzekry |
Machine learning versus mechanistic modeling for prediction of metastatic relapse in breast cancer |
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| 15:10-16:40 |
Coffee break, poster and software session I: posters in Group II (with poster numbers starting with II-) are accompanied by their presenter |
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| 16:40-16:45 |
Clinical pharmacometrics - ISoP special interest group |
Mirjam Trame and Eva Germovsek
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| 16:45-17:25 |
Clinical applications |
Chair: Oscar Della Pasqua
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| 16:45-17:05 |
João Abrantes |
Bayesian forecasting utilizing bleeding information to support dose individualization of factor VIII |
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| 17:05-17:25 |
Belén Pérez Solans |
Model-based characterization of neutrophil dynamics in children receiving busulfan or treosulfan for hematopoietic stem cell transplant conditioning |
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| 17:25-18:05 |
Rare (and other) diseases |
Chair: Panos Macheras
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| 17:25-17:45 |
Zinnia Parra-Guillen |
Disease pharmacokinetic-pharmacodynamic (PKPD) modelling to support the development of gene therapy treatments for rare diseases |
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| 17:45-18:05 |
Pascal Chanu |
A disease progression model for geographic atrophy |
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Thursday
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| 08:30-09:45 |
Lewis Sheiner Student Session |
Chair: Andrew Hooker, Emilie Hénin, Thomas Dorlo
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| 08:30-08:55 |
Moustafa M. A. Ibrahim |
Competing risks analysis of the Finnish diabetes prevention study |
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| 08:55-09:20 |
Sebastiaan Goulooze |
Novel pharmacometric techniques to quantify and prevent iatrogenic withdrawal in children |
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| 09:20-09:45 |
Elena Tosca |
Dynamic Energy Budget (DEB) based models of tumor-in-host growth inhibition and cachexia onset |
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| 09:45-09:50 |
Presentation LBS awards |
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| 09:50-09:55 |
Special announcement |
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| 09:55-11:20 |
Coffee break, poster and software session I: posters in Group III (with poster numbers starting with III-) are accompanied by their presenter |
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| 11:20-12:25 |
Regulatory model-informed drug discovery and development |
Chair: Aris Dokoumetzidis
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| 11:20-12:05 |
Kristin Karlsson |
Regulatory model-informed drug discovery and development in EU – News flash and examples |
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| 12:05-12:25 |
Sylvie Retout |
A model-based extrapolation enabled labelling of emicizumab in haemophilia A paediatric patients <1 year old despite lack of clinical data |
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| 12:25-12:30 |
ACoP Announcement |
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| 12:30-14:00 |
Lunch |
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| 12:30-14:00 |
ISoP Student Community meet-and-greet during lunch |
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| 14:00-15:20 |
Stuart Beal methodology session |
Chair: Emmanuelle Comets and Siv Jönsson
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| 14:00-14:20 |
Theodoros Papathanasiou |
Model based optimization of dose-finding studies for drug-combinations. |
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| 14:20-14:40 |
Antonio Goncalves |
Model Averaging in viral dynamic models |
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| 14:40-15:00 |
Mohammed Cherkaoui Rbati |
A liver model for chemoprotection against malaria |
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| 15:00-15:20 |
Xiao Zhu |
A cohesive model framework of receptor pharmacology: beyond the Emax model |
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| 15:20-15:25 |
WCoP Announcement |
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| 15:25-16:50 |
Coffee break, poster and software session I: posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter |
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| 16:50-17:30 |
Stuart Beal methodology session, continued |
Chair: Justin Wilkins
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| 16:50-17:10 |
Alison Margolskee |
Exploratory graphics (xGx): promoting the purposeful exploration of PKPD data |
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| 17:10-17:30 |
Marc Cerou |
Performance of npde for the evaluation of joint model with time to event data |
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| 18:30-01:00 |
Social event |
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Friday
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| 09:20-09:40 |
Oncology |
Chair: Ana Ruiz, Siv Jönsson
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| 09:20-09:40 |
Aurelia de Vries Schultink |
Prospective evaluation of Therapeutic Drug Monitoring of endoxifen: feasibility of observational and randomized trials. |
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| 09:40-10:00 |
Coralie Tardivon |
Association between tumor size kinetics and survival in advanced urothelial carcinoma patients treated with atezolizumab: implication for patient’s follow-up |
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| 10:00-10:20 |
Jiajie Yu |
A new approach to predict PFS in Ovarian Cancer based on tumor growth dynamics. |
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| 10:20-10:25 |
Preview of PAGE 2020 |
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| 10:25-11:00 |
Coffee break |
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| 11:00-11:40 |
Oncology, continued |
Chair: Marylore Chenel
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| 11:00-11:20 |
Julie Janssen |
A semi-physiological framework to predict changes in pharmacokinetics of cytotoxic drugs in pregnant women |
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| 11:20-11:40 |
James Lu |
Integrated efficacy-safety QSP model of acute myeloid leukemia (AML) generates insights into the role of clinical dose schedules on cytopenia |
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| 11:40-11:50 |
Closing remarks |
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| 11:50-12:05 |
Audience input for potential PAGE 2020 topics |
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