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Lewis Sheiner

Ljubljana, Slovenia

Stockholm, Sweden

Montreux, Switzerland

Budapest, Hungary

Lisboa, Portugal

Hersonissos, Crete, Greece

Alicante, Spain

Glasgow, Scotland

Venice, Italy

Athens, Greece

Berlin, Germany

St. Petersburg, Russia

Marseille, France

KÝbenhavn, Denmark

Brugge/Bruges, Belgium

Pamplona, Spain

Uppsala, Sweden

Verona, Italy

Paris, France

Basel, Switzerland

Salamanca, Spain

Saintes, France

Wuppertal, Germany

Glasgow, Scotland

Sandwich, UK

Frankfurt, Germany

Greenford, UK

Paris, France

Basel, Switzerland

Printable version



Tuesday 11 June


14:00-18:00 Registration at the Conference Venue
18:00-19:30 Welcome reception with drinks and light snacks (no dinner)


Wednesday 12 June


08:00-08:45 Registration
08:45-09:00 Welcome and Introduction
09:00-09:45 Keynote lecture

Chair: Dinesh De Alwis

09:00-09:45 Jeff Sachs Pharmacometrics: A shot in the arm for vaccine discovery and development ~or~ Vaccines are not immune to the charms of pharmacometrics
09:45-09:50 PAGE scientific program 

Siv Jönsson

09:50-11:15 Coffee break, Poster and Software session I
  Posters in Group I (with poster numbers starting with I-) are accompanied by their presenter
11:15-12:15 Infectious diseases

Chair: France Mentré

11:15-11:35 Marjorie Imperial Stratified medicine approaches for drug susceptible tuberculosis patients
11:35-11:55 Stefanie Hennig Repeated time-to-event models support that Pseudomonas aeruginosa infection increase the risk of acquiring Aspergillus in young children with cystic fibrosis
11:55-12:15 María García-Cremades Individual level data meta-analysis from HIV pre-exposure prophylaxis (PrEP) clinical trials
12:15-13:45 Lunch
13:45-14:30 Tutorial

Chair: Mats Karlsson

13:45-14:30 Nicky Best Use of informative priors in model-informed drug development 
14:30-15:10 Machine learning in oncology

Chairs: Mats Karlsson, Paolo Magni

14:30-14:50 Chiara Nicolò Machine learning combined to mechanistic modeling of differential effects of neoadjuvant sunitinib on primary tumor and metastatic growth
14:50-15:10 Sebastien Benzekry Machine learning versus mechanistic modeling for prediction of metastatic relapse in breast cancer
15:10-16:40 Tea break, Poster and Software session II
  Posters in Group II (with poster numbers starting with II-) are accompanied by their presenter
16:40-16:45 Clinical pharmacometrics - ISoP special interest group

Mirjam Trame and Eva Germovsek

16:45-17:25 Clinical applications

Chair: Oscar Della Pasqua

16:45-17:05 João Abrantes Bayesian forecasting utilizing bleeding information to support dose individualization of factor VIII
17:05-17:25 Belén Pérez Solans Model-based characterization of neutrophil dynamics in children receiving busulfan or treosulfan for hematopoietic stem cell transplant conditioning 
17:25-18:05 Rare (and other) diseases

Chair: Panos Macheras

17:25-17:45 Zinnia Parra-Guillen Disease pharmacokinetic-pharmacodynamic (PKPD) modelling to support the development of gene therapy treatments for rare diseases
17:45-18:05 Pascal Chanu A disease progression model for geographic atrophy


Thursday 13 June


08:30-09:50 Lewis Sheiner Student Session

Chair: Andrew Hooker, Emilie Hénin, Thomas Dorlo

08:30-08:55 Moustafa Mahmoud Abdellatif Ibrahim Competing risks analysis of the Finnish diabetes prevention study
08:55-09:20 Sebastiaan Goulooze Novel pharmacometric techniques to quantify and prevent iatrogenic withdrawal in children
09:20-09:45 Elena Tosca Dynamic Energy Budget (DEB) based models of tumor-in-host growth inhibition and cachexia onset
09:45-09:50 Presentation of Lewis Sheiner student session awards
09:50-09:55 Special announcement
09:55-11:20 Coffee break, Poster and Software session III
  Posters in Group III (with poster numbers starting with III-) are accompanied by their presenter
11:20-12:25 Regulatory model-informed drug discovery and development

Chair: Aris Dokoumetzidis

11:20-12:05 Kristin Karlsson and Flora Musuamba Tshinanu Regulatory model-informed drug discovery and development in EU – News flash and examples
12:05-12:25 Sylvie Retout A model-based extrapolation enabled labelling of emicizumab in haemophilia A paediatric patients
12:25-12:30 Announcement for ACoP10 2019

Mirjam Trame

12:30-14:00 Lunch
12:30-14:00 ISoP Student Community meet-and-greet during lunch
14:00-15:20 Stuart Beal methodology session

Chair: Emmanuelle Comets and Siv Jönsson

14:00-14:20 Theodoros Papathanasiou Model based optimization of dose-finding studies for drug-combinations
14:20-14:40 Antonio Goncalves Model averaging in viral dynamic models
14:40-15:00 Mohammed Cherkaoui Rbati A liver model for chemoprotection against malaria
15:00-15:20 Xiao Zhu A cohesive model framework of receptor pharmacology: beyond the Emax model
15:20-15:25 Announcement for WCoP 2020

15:25-16:50 Tea break, Poster and Software session IV
  Posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter
16:50-17:30 Stuart Beal methodology session, continued

Chair: Justin Wilkins

16:50-17:10 Alison Margolskee Exploratory graphics (xGx): promoting the purposeful exploration of PKPD data
17:10-17:30 Marc Cerou Performance of npde for the evaluation of joint model with time to event data
18:30-01:00 Social event


Friday 14 June


09:20-10:20 Oncology

Chair: Ana Ruiz, Siv Jönsson

09:20-09:40 Aurelia de Vries Schultink Prospective evaluation of therapeutic drug monitoring of endoxifen: feasibility of observational and randomized trials
09:40-10:00 Coralie Tardivon Association between tumor size kinetics and survival in advanced urothelial carcinoma patients treated with atezolizumab: implication for patient’s follow-up
10:00-10:20 Jiajie Yu A new approach to predict PFS in ovarian cancer based on tumor growth dynamics
10.20-10.25 Preview of PAGE 2020
10:25-11:00 Coffee break
11:00-11:40 Oncology, continued

Chair: Marylore Chenel

11:00-11:20 Julie Janssen A semi-physiological framework to predict changes in pharmacokinetics of cytotoxic drugs in pregnant women
11:20-11:40 James Lu Integrated efficacy-safety QSP model of acute myeloid leukemia (AML) generates insights into the role of clinical dose schedules on cytopenia
11.40-11.50 Closing remarks
11:50-12:10 Audience input for potential PAGE 2020 topics