2018 - Montreux - Switzerland

2018 - Montreux - Switzerland

 

Tuesday 29 May

 

14:00-18:00 Registration at the Conference Venue
       
18:30-21:30 Opening ceremony, welcome reception and dinner
       

 

Wednesday 30 May

 

08:00-08:45 Registration
       
08:45-09:00 Welcome and Introduction
       
09:00-10:10 Model-based dose individualisation – biomarker focus

Chair: Chantal Csajka, Nick Holford

09:00-09:20 Thierry Buclin Meeting clinicians' and patients' needs in the practice of therapeutic monitoring
09:20-09:50 Catherine Sherwin Model-based dose individualization approaches using biomarkers
09:50-10:10 Ron Keizer Experiences in applied clinical pharmacometrics: challenges, recommendations, and research opportunities
       
10:10-11:40 Coffee break, Poster and Software session I
  Posters in Group I (with poster numbers starting with I-) are accompanied by their presenter
       
11:40-12:20 Model-based dose individualisation – biomarker focus, continued

Chair: Chantal Csajka, Nick Holford 

11:40-12:00 Maddalena Centanni A pharmacometric framework for dose individualisation of sunitinib in GIST
12:00-12:20 Chloé Pasin Use of mathematical modeling for optimizing and adapting immunotherapy protocols in HIV-infected patients
       
12:20-13:00 Estimands

Chair: France Mentré

12:20-12:35 Mouna Akacha Background on estimands and why are they important?
12:35-12:50 Mick Looby PMX perspective on estimands
12:50-13:00   Discussion on estimands  
       
13:00-14:30 Lunch
       
14:30-15:50 Stuart Beal Methodology Session

Chair: Justin Wilkins

14:30-14:50 Camille Vong Power assessment for hierarchical combination endpoints using joint modelling of repeated time-to-event and time-to-event models versus Finkelstein-Schoenfeld method
14:50-15:10 Yixuan Zou A novel score test-based method for efficient covariate selection in population pharmacokinetic analysis
15:10-15:30 Qing Xi Ooi Evaluation of assumptions underpinning pharmacometric models
15:30-15:50 Mats Karlsson Extensive and automatic assumption assessment of pharmacometric models
       
15:50-17:20 Tea break, Poster and Software session II
  Posters in Group II (with poster numbers starting with II-) are accompanied by their presenter
       
17:20-17:40 Clinical applications

Chair: Marylore Chenel 

17:20-17:40 Oskar Alskär An integrated glucose homeostasis model of glucose, insulin, C-peptide, GLP-1, GIP and glucagon in healthy subjects and patients with Type 2 diabetes
       
17:40-18:00 Pharmacoeconomics

Chair: Marylore Chenel 

17:40-18:00 Daniel Hill-McManus Application of a linked pharmacometric/pharmacoeconomic model to assess the impact of non-adherence: Application to the treatment of gout
       
       

 

Thursday 31 May

 

08:30-09:55 Lewis Sheiner Student Session

Chair: Julie Bertrand, Alain Munafo, Ana Ruiz 

08:30-08:50 Simon Buatois A pharmacometric extension of MCP-MOD in dose finding studies
08:50-09:10 Benjamin Guiastrennec New dosing recommendations for anti-tuberculosis therapy in Indian children
09:10-09:30 Jurgen Langenhorst Cause-specific hazard models with Markovian elements to quantify the fludarabine exposure-response relationship: from learning to confirming in allogeneic hematopoietic cell transplantation
09:30-09:50 Gustaf Wellhagen A bounded integer model for rating and composite scale data
09.50-09.55 Presentation of Lewis Sheiner student session awards
       
09:55-11:30 Coffee break, Poster and Software session III
  Posters in Group III (with poster numbers starting with III-) are accompanied by their presenter
       
11:30-12:30 Oncology

Chair: Lena Friberg

11:30-11:50 Phyllis Chan Assessment of a model to correlate early tumor size response to overall survival in relapsed or refractory diffuse large B cell lymphoma patients
11:50-12:10 Rui Zhu Exposure-response (E-R)-based product-profile (PP)-driven clinical utility index (CUI) to support phase III dose selection in oncology 
12:10-12:30 Zinnia Parra-Guillen A quantitative modelling framework to inform dose selection of Xentuzumab, a dual insulin-like growth factor-I/II neutralizing antibody in cancer patients
       
12:30-12:35 Announcement for ACoP9 (2018)

CJ Musante

       
12:35-14:10 Lunch
       
14:10-15:10 Immuno-oncology

Chair: Dinesh de Alwis, Pascal Girard

14:10-14:40 Scott K Pruitt Clinical overview of immunotherapy in oncology
14:40-15:10 Benjamin Ribba Drug response variability and optimal dosing in immuno-oncology
       
15:10-16:40 Tea break, Poster and Software session IV
  Posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter
       
16:40-17:20 Immuno-oncology, continued

Chair: Dinesh de Alwis, Pascal Girard

16:40-17:00 Rukmini Kumar Predicting response and identifying responders to combination cancer immunotherapy in melanoma using Quantitative Systems Pharmacology (QSP) models
17:00-17:20 Hanna Silber Baumann PKPD analysis of soluble CD25 to characterize the concentration-effect relationship observed following the administration of Cergutuzumab Amunaleukin, a targeted immunocytokine for cancer immunotherapy
       
17:20-17:25 Announcement for WCoP 2020

Stacey Tannenbaum 

       
18:30-01:30 Social event
       

 

Friday 1 June

 

09:15-09:55 Clinical Applications

Chair: Marylore Chenel

09:15-09:35 David Ternant Population and Bayesian kinetic modelling of necrosis biomarkers to assess the effect of conditioning therapies on infarct size
09:35-09:55 João Abrantes Integrated modelling of factor VIII activity kinetics, occurrence of bleeds and individual characteristics in haemophilia A patients using a full random effects modelling approach (FREM)
       
09:55-10:35 Systems pharmacology

Chair: Charlotte Kloft

09:55-10:15 Chihiro Hasegawa Simplification of multi-scale systems models for data-driven analyses: what has progressed in these 5 years?
10:15-10:35 Elin Boger A partial differential equation approach to inhalation PBPK modelling
       
10:35-10:40 Preview of PAGE 2019
       
10:40-11:20 Coffee break and Software session
       
11:20-11:30 DDMoRe Model Repository challenge – prize ceremony 

Chair: Thomas Dorlo, Céline Sarr 

       
11:30-12:10 Antivirals

Chair: Thomas Dorlo

11:30-11:50 Sulav Duwal A multiscale mechanistic framework to predict drug-class specific prophylactic efficacy of antiviral drugs against HIV
11:50-12:10 Vincent Madelain Ebola viral dynamics in nonhuman primates: insights into virus immuno-pathogenesis and antiviral strategies
       
12.10-12.20 Closing remarks
       
12:20-12:35 Audience input for potential PAGE2019 topics
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