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Lewis Sheiner


2019
Stockholm, Sweden



2018
Montreux, Switzerland
   Program
   Organisers
   Abstracts
   Participants

2017
Budapest, Hungary

2016
Lisboa, Portugal

2015
Hersonissos, Crete, Greece

2014
Alicante, Spain

2013
Glasgow, Scotland

2012
Venice, Italy

2011
Athens, Greece

2010
Berlin, Germany

2009
St. Petersburg, Russia

2008
Marseille, France

2007
KÝbenhavn, Denmark

2006
Brugge/Bruges, Belgium

2005
Pamplona, Spain

2004
Uppsala, Sweden

2003
Verona, Italy

2002
Paris, France

2001
Basel, Switzerland

2000
Salamanca, Spain

1999
Saintes, France

1998
Wuppertal, Germany

1997
Glasgow, Scotland

1996
Sandwich, UK

1995
Frankfurt, Germany

1994
Greenford, UK

1993
Paris, France

1992
Basel, Switzerland

Printable version

 

Tuesday 29 May

 

14:00-18:00 Registration at the Conference Venue
       
18:30-21:30 Opening ceremony, welcome reception and dinner
       

 

Wednesday 30 May

 

08:00-08:45 Registration
       
08:45-09:00 Welcome and Introduction
       
09:00-10:10 Model-based dose individualisation – biomarker focus

Chair: Chantal Csajka, Nick Holford

09:00-09:20 Thierry Buclin Meeting clinicians' and patients' needs in the practice of therapeutic monitoring
09:20-09:50 Catherine Sherwin Model-based dose individualization approaches using biomarkers
09:50-10:10 Ron Keizer Experiences in applied clinical pharmacometrics: challenges, recommendations, and research opportunities
       
10:10-11:40 Coffee break, Poster and Software session I
  Posters in Group I (with poster numbers starting with I-) are accompanied by their presenter
       
11:40-12:20 Model-based dose individualisation – biomarker focus, continued

Chair: Chantal Csajka, Nick Holford 

11:40-12:00 Maddalena Centanni A pharmacometric framework for dose individualisation of sunitinib in GIST
12:00-12:20 Chloé Pasin Use of mathematical modeling for optimizing and adapting immunotherapy protocols in HIV-infected patients
       
12:20-13:00 Estimands

Chair: France Mentré

12:20-12:35 Mouna Akacha Background on estimands and why are they important?
12:35-12:50 Mick Looby PMX perspective on estimands
12:50-13:00   Discussion on estimands  
       
13:00-14:30 Lunch
       
14:30-15:50 Stuart Beal Methodology Session

Chair: Justin Wilkins

14:30-14:50 Camille Vong Power assessment for hierarchical combination endpoints using joint modelling of repeated time-to-event and time-to-event models versus Finkelstein-Schoenfeld method
14:50-15:10 Yixuan Zou A novel score test-based method for efficient covariate selection in population pharmacokinetic analysis
15:10-15:30 Qing Xi Ooi Evaluation of assumptions underpinning pharmacometric models
15:30-15:50 Mats Karlsson Extensive and automatic assumption assessment of pharmacometric models
       
15:50-17:20 Tea break, Poster and Software session II
  Posters in Group II (with poster numbers starting with II-) are accompanied by their presenter
       
17:20-17:40 Clinical applications

Chair: Marylore Chenel 

17:20-17:40 Oskar Alskär An integrated glucose homeostasis model of glucose, insulin, C-peptide, GLP-1, GIP and glucagon in healthy subjects and patients with Type 2 diabetes
       
17:40-18:00 Pharmacoeconomics

Chair: Marylore Chenel 

17:40-18:00 Daniel Hill-McManus Application of a linked pharmacometric/pharmacoeconomic model to assess the impact of non-adherence: Application to the treatment of gout
       
       

 

Thursday 31 May

 

08:30-09:55 Lewis Sheiner Student Session

Chair: Julie Bertrand, Alain Munafo, Ana Ruiz 

08:30-08:50 Simon Buatois A pharmacometric extension of MCP-MOD in dose finding studies
08:50-09:10 Benjamin Guiastrennec New dosing recommendations for anti-tuberculosis therapy in Indian children
09:10-09:30 Jurgen Langenhorst Cause-specific hazard models with Markovian elements to quantify the fludarabine exposure-response relationship: from learning to confirming in allogeneic hematopoietic cell transplantation
09:30-09:50 Gustaf Wellhagen A bounded integer model for rating and composite scale data
09.50-09.55 Presentation of Lewis Sheiner student session awards
       
09:55-11:30 Coffee break, Poster and Software session III
  Posters in Group III (with poster numbers starting with III-) are accompanied by their presenter
       
11:30-12:30 Oncology

Chair: Lena Friberg

11:30-11:50 Phyllis Chan Assessment of a model to correlate early tumor size response to overall survival in relapsed or refractory diffuse large B cell lymphoma patients
11:50-12:10 Rui Zhu Exposure-response (E-R)-based product-profile (PP)-driven clinical utility index (CUI) to support phase III dose selection in oncology 
12:10-12:30 Zinnia Parra-Guillen A quantitative modelling framework to inform dose selection of Xentuzumab, a dual insulin-like growth factor-I/II neutralizing antibody in cancer patients
       
12:30-12:35 Announcement for ACoP9 (2018)

CJ Musante

       
12:35-14:10 Lunch
       
14:10-15:10 Immuno-oncology

Chair: Dinesh de Alwis, Pascal Girard

14:10-14:40 Scott K Pruitt Clinical overview of immunotherapy in oncology
14:40-15:10 Benjamin Ribba Drug response variability and optimal dosing in immuno-oncology
       
15:10-16:40 Tea break, Poster and Software session IV
  Posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter
       
16:40-17:20 Immuno-oncology, continued

Chair: Dinesh de Alwis, Pascal Girard

16:40-17:00 Rukmini Kumar Predicting response and identifying responders to combination cancer immunotherapy in melanoma using Quantitative Systems Pharmacology (QSP) models
17:00-17:20 Hanna Silber Baumann PKPD analysis of soluble CD25 to characterize the concentration-effect relationship observed following the administration of Cergutuzumab Amunaleukin, a targeted immunocytokine for cancer immunotherapy
       
17:20-17:25 Announcement for WCoP 2020

Stacey Tannenbaum 

       
18:30-01:30 Social event
       

 

Friday 1 June

 

09:15-09:55 Clinical Applications

Chair: Marylore Chenel

09:15-09:35 David Ternant Population and Bayesian kinetic modelling of necrosis biomarkers to assess the effect of conditioning therapies on infarct size
09:35-09:55 João Abrantes Integrated modelling of factor VIII activity kinetics, occurrence of bleeds and individual characteristics in haemophilia A patients using a full random effects modelling approach (FREM)
       
09:55-10:35 Systems pharmacology

Chair: Charlotte Kloft

09:55-10:15 Chihiro Hasegawa Simplification of multi-scale systems models for data-driven analyses: what has progressed in these 5 years?
10:15-10:35 Elin Boger A partial differential equation approach to inhalation PBPK modelling
       
10:35-10:40 Preview of PAGE 2019
       
10:40-11:20 Coffee break and Software session
       
11:20-11:30 DDMoRe Model Repository challenge – prize ceremony 

Chair: Thomas Dorlo, Céline Sarr 

       
11:30-12:10 Antivirals

Chair: Thomas Dorlo

11:30-11:50 Sulav Duwal A multiscale mechanistic framework to predict drug-class specific prophylactic efficacy of antiviral drugs against HIV
11:50-12:10 Vincent Madelain Ebola viral dynamics in nonhuman primates: insights into virus immuno-pathogenesis and antiviral strategies
       
12.10-12.20 Closing remarks
       
12:20-12:35 Audience input for potential PAGE2019 topics