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Lewis Sheiner

Stockholm, Sweden

Montreux, Switzerland

Budapest, Hungary

Lisboa, Portugal

Hersonissos, Crete, Greece

Alicante, Spain

Glasgow, Scotland

Venice, Italy

Athens, Greece

Berlin, Germany

St. Petersburg, Russia

Marseille, France

KÝbenhavn, Denmark

Brugge/Bruges, Belgium

Pamplona, Spain

Uppsala, Sweden

Verona, Italy

Paris, France

Basel, Switzerland

Salamanca, Spain

Saintes, France

Wuppertal, Germany

Glasgow, Scotland

Sandwich, UK

Frankfurt, Germany

Greenford, UK

Paris, France

Basel, Switzerland

Printable version


Tuesday 29 May


14:00-18:00 Registration at the Conference Venue
18:30-21:30 Opening ceremony, welcome reception and dinner


Wednesday 30 May


08:00-08:45 Registration
08:45-09:00 Welcome and Introduction
09:00-10:10 Model-based dose individualisation – biomarker focus

Chair: Chantal Csajka, Nick Holford

09:00-09:20 Thierry Buclin Meeting clinicians' and patients' needs in the practice of therapeutic monitoring
09:20-09:50 Catherine Sherwin Model-based dose individualization approaches using biomarkers
09:50-10:10 Ron Keizer Experiences in applied clinical pharmacometrics: challenges, recommendations, and research opportunities
10:10-11:40 Coffee break, Poster and Software session I
  Posters in Group I (with poster numbers starting with I-) are accompanied by their presenter
11:40-12:20 Model-based dose individualisation – biomarker focus, continued

Chair: Chantal Csajka, Nick Holford 

11:40-12:00 Maddalena Centanni A pharmacometric framework for dose individualisation of sunitinib in GIST
12:00-12:20 Chloé Pasin Use of mathematical modeling for optimizing and adapting immunotherapy protocols in HIV-infected patients
12:20-13:00 Estimands

Chair: France Mentré

12:20-12:35 Mouna Akacha Background on estimands and why are they important?
12:35-12:50 Mick Looby PMX perspective on estimands
12:50-13:00   Discussion on estimands  
13:00-14:30 Lunch
14:30-15:50 Stuart Beal Methodology Session

Chair: Justin Wilkins

14:30-14:50 Camille Vong Power assessment for hierarchical combination endpoints using joint modelling of repeated time-to-event and time-to-event models versus Finkelstein-Schoenfeld method
14:50-15:10 Yixuan Zou A novel score test-based method for efficient covariate selection in population pharmacokinetic analysis
15:10-15:30 Qing Xi Ooi Evaluation of assumptions underpinning pharmacometric models
15:30-15:50 Mats Karlsson Extensive and automatic assumption assessment of pharmacometric models
15:50-17:20 Tea break, Poster and Software session II
  Posters in Group II (with poster numbers starting with II-) are accompanied by their presenter
17:20-17:40 Clinical applications

Chair: Marylore Chenel 

17:20-17:40 Oskar Alskär An integrated glucose homeostasis model of glucose, insulin, C-peptide, GLP-1, GIP and glucagon in healthy subjects and patients with Type 2 diabetes
17:40-18:00 Pharmacoeconomics

Chair: Marylore Chenel 

17:40-18:00 Daniel Hill-McManus Application of a linked pharmacometric/pharmacoeconomic model to assess the impact of non-adherence: Application to the treatment of gout


Thursday 31 May


08:30-09:55 Lewis Sheiner Student Session

Chair: Julie Bertrand, Alain Munafo, Ana Ruiz 

08:30-08:50 Simon Buatois A pharmacometric extension of MCP-MOD in dose finding studies
08:50-09:10 Benjamin Guiastrennec New dosing recommendations for anti-tuberculosis therapy in Indian children
09:10-09:30 Jurgen Langenhorst Cause-specific hazard models with Markovian elements to quantify the fludarabine exposure-response relationship: from learning to confirming in allogeneic hematopoietic cell transplantation
09:30-09:50 Gustaf Wellhagen A bounded integer model for rating and composite scale data
09.50-09.55 Presentation of Lewis Sheiner student session awards
09:55-11:30 Coffee break, Poster and Software session III
  Posters in Group III (with poster numbers starting with III-) are accompanied by their presenter
11:30-12:30 Oncology

Chair: Lena Friberg

11:30-11:50 Phyllis Chan Assessment of a model to correlate early tumor size response to overall survival in relapsed or refractory diffuse large B cell lymphoma patients
11:50-12:10 Rui Zhu Exposure-response (E-R)-based product-profile (PP)-driven clinical utility index (CUI) to support phase III dose selection in oncology 
12:10-12:30 Zinnia Parra-Guillen A quantitative modelling framework to inform dose selection of Xentuzumab, a dual insulin-like growth factor-I/II neutralizing antibody in cancer patients
12:30-12:35 Announcement for ACoP9 (2018)

CJ Musante

12:35-14:10 Lunch
14:10-15:10 Immuno-oncology

Chair: Dinesh de Alwis, Pascal Girard

14:10-14:40 Scott K Pruitt Clinical overview of immunotherapy in oncology
14:40-15:10 Benjamin Ribba Drug response variability and optimal dosing in immuno-oncology
15:10-16:40 Tea break, Poster and Software session IV
  Posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter
16:40-17:20 Immuno-oncology, continued

Chair: Dinesh de Alwis, Pascal Girard

16:40-17:00 Rukmini Kumar Predicting response and identifying responders to combination cancer immunotherapy in melanoma using Quantitative Systems Pharmacology (QSP) models
17:00-17:20 Hanna Silber Baumann PKPD analysis of soluble CD25 to characterize the concentration-effect relationship observed following the administration of Cergutuzumab Amunaleukin, a targeted immunocytokine for cancer immunotherapy
17:20-17:25 Announcement for WCoP 2020

Stacey Tannenbaum 

18:30-01:30 Social event


Friday 1 June


09:15-09:55 Clinical Applications

Chair: Marylore Chenel

09:15-09:35 David Ternant Population and Bayesian kinetic modelling of necrosis biomarkers to assess the effect of conditioning therapies on infarct size
09:35-09:55 João Abrantes Integrated modelling of factor VIII activity kinetics, occurrence of bleeds and individual characteristics in haemophilia A patients using a full random effects modelling approach (FREM)
09:55-10:35 Systems pharmacology

Chair: Charlotte Kloft

09:55-10:15 Chihiro Hasegawa Simplification of multi-scale systems models for data-driven analyses: what has progressed in these 5 years?
10:15-10:35 Elin Boger A partial differential equation approach to inhalation PBPK modelling
10:35-10:40 Preview of PAGE 2019
10:40-11:20 Coffee break and Software session
11:20-11:30 DDMoRe Model Repository challenge – prize ceremony 

Chair: Thomas Dorlo, Céline Sarr 

11:30-12:10 Antivirals

Chair: Thomas Dorlo

11:30-11:50 Sulav Duwal A multiscale mechanistic framework to predict drug-class specific prophylactic efficacy of antiviral drugs against HIV
11:50-12:10 Vincent Madelain Ebola viral dynamics in nonhuman primates: insights into virus immuno-pathogenesis and antiviral strategies
12.10-12.20 Closing remarks
12:20-12:35 Audience input for potential PAGE2019 topics