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Lewis Sheiner

Stockholm, Sweden

Montreux, Switzerland

Budapest, Hungary

Lisboa, Portugal

Hersonissos, Crete, Greece

Alicante, Spain

Glasgow, Scotland

Venice, Italy

Athens, Greece

Berlin, Germany

St. Petersburg, Russia

Marseille, France

KÝbenhavn, Denmark

Brugge/Bruges, Belgium

Pamplona, Spain

Uppsala, Sweden

Verona, Italy

Paris, France

Basel, Switzerland

Salamanca, Spain

Saintes, France

Wuppertal, Germany

Glasgow, Scotland

Sandwich, UK

Frankfurt, Germany

Greenford, UK

Paris, France

Basel, Switzerland

Printable version


Tuesday 7 June


14:00-18:00 Registration at the Conference Venue
19:30-21:00 Welcome reception


Wednesday 8 June


08:00-08:45 Registration
08:45-09:00 Welcome and Introduction
09:00-10:20 Immune response to drug treatment and immunotherapy

Chair: Oscar Della Pasqua, Dinesh De Alwis

09:00-09:40 Nigel Klein A biological perspective on immune response to drug treatment (intended and unintended effects)
09:40-10:00 Hans Peter Grimm Intricate PK and PD for the novel immunocytokine CEA-IL2v and their pre-clinical to clinical translation
10:00-10:20 Kirill Peskov Investigation of anti-CTLA-4 immuno-oncology therapy through a quantitative systems pharmacology model
10:20-11:40 Coffee break, Poster and Software session I
  Posters in Group I (with poster numbers starting with I-) are accompanied by their presenter
11:40-12:20 Systems pharmacology

Chair: Charlotte Kloft

11:40-12:00 Kapil Gadkar A Six-Stage Workflow for Robust Application of Systems Pharmacology
12:00-12:20 Rob van Wijk The zebrafish as model for translational systems pharmacology: expanding the allometric scale in vertebrates with five orders of magnitude
12:20-13:50 Lunch
13:50-15:05 Growth (I)

Chair: Leon Aarons, Shasha Jumbe

13:50-14:05 Shasha Jumbe Introduction to the Gates' Healthy Birth, Growth & Development knowledge integration project
14:05-14:45 Louise Ryan Trajectory modelling based on early childhood longitudinal growth data
14:45-15:05 Niclas Jonsson Determinants for physical growth patterns in low- and middle-income countries
15:05-15:10 Announcement of WCoP 2016

Nick Holford

15:10-16:40 Tea break, Poster and Software session II
  Posters in Group II (with poster numbers starting with II-) are accompanied by their presenter
16:40-17:20 Growth (II)

Chair: Leon Aarons, Shasha Jumbe

16:40-17:00 Mélanie Wilbaux Characterizing and Forecasting Individual Weight Changes in Term Neonates
17:00-17:20 Nick Holford Growth and decline of body size and composition – Prediction of the transition from pre-diabetes to Type 2 diabetes in humans
17:40-18:20 Other applications

Chair: Leon Aarons, Shasha Jumbe

17:40-18:00 Thi Huyen Tram Nguyen The paradox of highly effective sofosbuvir combo therapy despite slow viral decline
18:00-18:20 Rik Schoemaker Extrapolation of a Brivaracetam Exposure-Response Model from Adults to Children
18:30-18:50 Special surprise...


Thursday 9 June


08:45-10:05 Lewis Sheiner Student Session

Chair: Marylore Chenel, Aris Dokoumetzidis, Leonid Gibiansky

08:45-09:10 Elin Svensson Bedaquiline's exposure-response relationship revealed through modeling of mycobacterial load
09:10-09:35 Solène Desmée Joint modelling for nonlinear longitudinal PSA kinetics and survival data in metastatic prostate cancer patients
09:35-10:00 Stein Schalkwijk A physiologically-based population pharmacokinetic analysis to assess a lower efavirenz dose of 400 mg once daily in HIV-infected pregnant women
10.00-10.05 Presentation of Lewis Sheiner student session awards
10:05-11:30 Coffee break, Poster and Software session III
  Posters in Group III (with poster numbers starting with III-) are accompanied by their presenter
11:30-12:30 Oncology

Chair: Ana Ruiz

11:30-11:50 Matts Kågedal Time-to-Event Modeling of Peripheral Neuropathy – Platform Mega-Analysis of Eight vc-MMAE Antibody-Drug Conjugates (ADCs)
11:50-12:10 Lucy Hutchinson Mathematical modelling of transient tumour growth dynamics following anti-angiogenic therapy
12:10-12:30 Maria Luisa Sardu Modelling of classified individual tumor lesions in metastatic colorectal cancer (mCRC) patients using delay differential equations
12:30-13:50 Lunch
13:50-14:35 Tutorial: Estimation methods

Chair: France Mentré

13:50-14:35 Robert Bauer An overview of Estimation-Maximization Algorithms Used in Population Analysis Methods
14:35-14:40 Announcement of ACoP7

Brian Corrigan

14:40-16:00 Tea break, Poster and Software session IV
  Posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter
16:00-17:20 Stuart Beal Methodology Session

Chair: Paolo Magni

16:00-16:20 Yevgen Ryeznik Adaptive dose finding for time-to-event outcomes with adaptive choice of patient number based on response rate
16:20-16:40 Sebastian Wicha A general pharmacodynamic interaction model based on the Bliss Independence criterion
16:40-17:00 Martin Fink Improving priors for human mAb linear PK parameters by using half-lives from pre-clinical studies
17:00-17:20 David McDougall The Impact of Model Selection for Personalised Dosing
20:00-01:00 Social event: Buses depart from the Conference Venue at 19:30


Friday 10 June


09:00-10:00 Model-based approaches to aid in choice of dose and study design

Chair: Justin Wilkins

09:00-09:20 Lutz Harnisch Modelling and simulation of neurological endpoints (modified Rankin Scale [mRS] and National Institute of Health Stroke Scale [NIHSS]) to aid clinical trial design in intracerebral hemorrhage (ICH)
09:20-09:40 Oliver Sander Model-based development of the secukinumab dosing regimen for the treatment of moderate-to-severe chronic plaque psoriasis
09:40-10:00 Rasmus Vestergaard Juul Repeated time to event modelling of opioid consumption in postoperative pain
10:00-10:20 Thu Thuy Nguyen Limited sampling strategy for a population pharmacokinetic modelling of cocktail of phenotyping drugs
10.20-10.30 Preview of PAGE 2017
10:30-11:00 Coffee break and Software session
11:00-12:00 Central Nervous System Diseases

Chair: Nick Holford

11:00-11:20 Sylvie Retout How disease modeling and model-based meta-analyses contributed to understanding the path forward after dose discontinuation of a Phase III study in Alzheimer's disease
11:20-11:40 Marc Vandemeulebroecke A longitudinal Item Response Theory model to characterize cognition over time in elderly subjects
11:40-12:00 Simon Buatois Utilizing the items from the MDS-UPDRS score to increase drug effect detection power in de novo idiopathic Parkinson's disease
12.00-12.10 Closing remarks
12:10-12:30 Audience input for potential PAGE2017 topics