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Lewis Sheiner

Stockholm, Sweden

Montreux, Switzerland

Budapest, Hungary

Lisboa, Portugal

Hersonissos, Crete, Greece

Alicante, Spain

Glasgow, Scotland

Venice, Italy

Athens, Greece

Berlin, Germany

St. Petersburg, Russia

Marseille, France

KÝbenhavn, Denmark

Brugge/Bruges, Belgium

Pamplona, Spain

Uppsala, Sweden

Verona, Italy

Paris, France

Basel, Switzerland

Salamanca, Spain

Saintes, France

Wuppertal, Germany

Glasgow, Scotland

Sandwich, UK

Frankfurt, Germany

Greenford, UK

Paris, France

Basel, Switzerland

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Tuesday June 11


15:00-18:30 Registration
18:30-19:30 Welcome reception at the Old Fruitmarket located on Candleriggs in the Merchant City area, close to the city centre.  Please see the map on


Wednesday June 12


08:00-08:45 Registration
08:45-09:00 Welcome and introduction
09:00-10:20 Model-based approaches in benefit-risk assessment and decision making chair: Oscar Della Pasqua
09:00-09:40 Dyfrig Hughes Quantitative benefit-risk analysis based on linked PKPD and health outcome modelling  
09:40-10:00 Jonathan French Can methods based on existing models really aid decision making in non-small-cell lung cancer (NSCLC) trials?  
10:00-10:20 Jonas Bech Møller Optimizing clinical diabetes drug development – what is the recipe?  
10:20-11:45 Coffee break, poster and software session I
  Posters in Group I (with poster numbers starting with I-) are accompanied by their presenter
11:45-12:25 Animal health (I) chairs: Alison Thomson & Jonathan Mochel
11:45-12:25 Jim Riviere Food safety: the intersection of pharmacometrics and veterinary medicine  
12:25-13:50 Lunch
13:50-14:50 Animal health (II) chairs: Alison Thomson & Jonathan Mochel
13:50-14:20 George Gettinby Two models for the control of sea lice infections using chemical treatments and biological control on farmed salmon populations  
14:20-14:50 Daniel Haydon From epidemic to elimination: density-vague transmission and the design of mass dog vaccination programs  
14:50-16:20 Tea break, poster and software session II
  Posters in Group II (with poster numbers starting with II-) are accompanied by their presenter
16:20-17:40 Modelling and evaluation methods with (potential) application to infectious diseases chair: Leon Aarons
16:20-16:40 Wojciech Krzyzanski Physiologically structured population model of intracellular hepatitis C virus dynamics  
16:40-17:00 Martin Bergstrand Modeling of the concentration-effect relationship for piperaquine in preventive treatment of malaria  
17:00-17:20 Matt Hutmacher A Visual Predictive Check for the evaluation of the hazard function in time-to-event analyses  
17:20-17:40 Celine Laffont Non-inferiority clinical trials: a multivariate test for multivariate PD  


Thursday June 13


08:45-10:05 Lewis Sheiner student session

chairs: Lena Friberg, Philippe Jacqmin & Leon Aarons

08:45-09:10 Abhishek Gulati Simplification of a multi-scale systems coagulation model with an application to modelling PKPD data  
09:10-09:35 Nelleke Snelder Mechanism-based PKPD modeling of cardiovascular effects in conscious rats - an application to fingolimod  
09:35-10:00 Nadia Terranova Mathematical models of tumor growth inhibition in xenograft mice after administration of anticancer agents given in combination  
10:00-10:05 Presentation of awards  
10:05-11:35 Coffee break, poster and software session III
  Posters in Group III (with poster numbers starting with III-) are accompanied by their presenter
11:35-12:35 Mechanistic modelling chair: Nick Holford
11:35-11:55 James Lu Application of a mechanistic, systems model of lipoprotein metabolism and kinetics to target selection and biomarker identification in the reverse cholesterol transport (RCT) pathway  
11:55-12:15 Rollo Hoare A novel mechanistic model for CD4 lymphocyte reconstitution following paediatric haematopoietic stem cell transplantation  
12:15-12:35 Huub Jan Kleijn Utilization of tracer kinetic data in endogenous pathway modeling: example from Alzheimer’s disease  
12:35-14:05 Lunch
14:05-14:55 Reproducibility and translation chair: Katya Gibiansky
14:05-14:35 Niclas Jonsson and Justin Wilkins Tutorial: Reproducible pharmacometrics  
14:35-14:55 Nick Holford
(on behalf of DDMoRe)
MDL - The DDMoRe modelling description language  
14:55-16:20 Tea break, poster and software session IV
  Posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter
16:20-17:20 New methods for population analysis chair: France Mentré
16:20-16:40 Vittal Shivva Identifiability of population pharmacokinetic-pharmacodynamic models  
16:40-17:00 Leonid Gibiansky Methods to detect non-compliance and minimize its impact on population PK parameter estimates  
17:00-17:20 Julie Bertrand Penalized regression implementation within the SAEM algorithm to advance high-throughput personalized drug therapy  
  Social evening


Friday June 14


09:00-10:00 Development and application of models in oncology chair: Marylore Chenel
09:00-09:20 Shelby Wilson Modeling the synergism between the anti-angiogenic drug sunitinib and irinotecan in xenografted mice  
09:20-09:40 Amy Cheung Using a model based approach to inform dose escalation in a Ph I Study by combining emerging clinical and prior preclinical information: an example in oncology  
09:40-10:00 Sonya Tate Tumour growth inhibition modelling and prediction of overall survival in patients with metastatic breast cancer treated with paclitaxel alone or in combination with gemcitabine
10:00-10:10 Preview of PAGE 2014
10:10-10:50 Coffee break
10:50-12:10 Stuart Beal methodology session chair: Steve Duffull
10:50-11:10 Chuanpu Hu Latent variable indirect response modeling of continuous and categorical clinical endpoints  
11:10-11:30 Anne-Gaelle Dosne Application of Sampling Importance Resampling to estimate parameter uncertainty distributions  
11:30-11:50 Hoai Thu Thai Bootstrap methods for estimating uncertainty of parameters in mixed-effects models  
11:50-12:10 Celia Barthelemy New methods for complex models defined by a large number of ODEs: application to a glucose/insulin model  
12:10-12:20 Closing remarks
12:20-12:40 Audience input for the PAGE 2014 program