2013 - Glasgow - Scotland

2013 - Glasgow - Scotland


Tuesday June 11


15:00-18:30 Registration
18:30-19:30 Welcome reception at the Old Fruitmarket located on Candleriggs in the Merchant City area, close to the city centre.  Please see the map on http://www.glasgowconcerthalls.com/maps


Wednesday June 12


08:00-08:45 Registration
08:45-09:00 Welcome and introduction
09:00-10:20 Model-based approaches in benefit-risk assessment and decision making chair: Oscar Della Pasqua
09:00-09:40 Dyfrig Hughes Quantitative benefit-risk analysis based on linked PKPD and health outcome modelling  
09:40-10:00 Jonathan French Can methods based on existing models really aid decision making in non-small-cell lung cancer (NSCLC) trials?  
10:00-10:20 Jonas Bech Møller Optimizing clinical diabetes drug development – what is the recipe?  
10:20-11:45 Coffee break, poster and software session I
  Posters in Group I (with poster numbers starting with I-) are accompanied by their presenter
11:45-12:25 Animal health (I) chairs: Alison Thomson & Jonathan Mochel
11:45-12:25 Jim Riviere Food safety: the intersection of pharmacometrics and veterinary medicine  
12:25-13:50 Lunch
13:50-14:50 Animal health (II) chairs: Alison Thomson & Jonathan Mochel
13:50-14:20 George Gettinby Two models for the control of sea lice infections using chemical treatments and biological control on farmed salmon populations  
14:20-14:50 Daniel Haydon From epidemic to elimination: density-vague transmission and the design of mass dog vaccination programs  
14:50-16:20 Tea break, poster and software session II
  Posters in Group II (with poster numbers starting with II-) are accompanied by their presenter
16:20-17:40 Modelling and evaluation methods with (potential) application to infectious diseases chair: Leon Aarons
16:20-16:40 Wojciech Krzyzanski Physiologically structured population model of intracellular hepatitis C virus dynamics  
16:40-17:00 Martin Bergstrand Modeling of the concentration-effect relationship for piperaquine in preventive treatment of malaria  
17:00-17:20 Matt Hutmacher A Visual Predictive Check for the evaluation of the hazard function in time-to-event analyses  
17:20-17:40 Celine Laffont Non-inferiority clinical trials: a multivariate test for multivariate PD  


Thursday June 13


08:45-10:05 Lewis Sheiner student session

chairs: Lena Friberg, Philippe Jacqmin & Leon Aarons

08:45-09:10 Abhishek Gulati Simplification of a multi-scale systems coagulation model with an application to modelling PKPD data  
09:10-09:35 Nelleke Snelder Mechanism-based PKPD modeling of cardiovascular effects in conscious rats - an application to fingolimod  
09:35-10:00 Nadia Terranova Mathematical models of tumor growth inhibition in xenograft mice after administration of anticancer agents given in combination  
10:00-10:05 Presentation of awards  
10:05-11:35 Coffee break, poster and software session III
  Posters in Group III (with poster numbers starting with III-) are accompanied by their presenter
11:35-12:35 Mechanistic modelling chair: Nick Holford
11:35-11:55 James Lu Application of a mechanistic, systems model of lipoprotein metabolism and kinetics to target selection and biomarker identification in the reverse cholesterol transport (RCT) pathway  
11:55-12:15 Rollo Hoare A novel mechanistic model for CD4 lymphocyte reconstitution following paediatric haematopoietic stem cell transplantation  
12:15-12:35 Huub Jan Kleijn Utilization of tracer kinetic data in endogenous pathway modeling: example from Alzheimer’s disease  
12:35-14:05 Lunch
14:05-14:55 Reproducibility and translation chair: Katya Gibiansky
14:05-14:35 Niclas Jonsson and Justin Wilkins Tutorial: Reproducible pharmacometrics  
14:35-14:55 Nick Holford
(on behalf of DDMoRe)
MDL - The DDMoRe modelling description language  
14:55-16:20 Tea break, poster and software session IV
  Posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter
16:20-17:20 New methods for population analysis chair: France Mentré
16:20-16:40 Vittal Shivva Identifiability of population pharmacokinetic-pharmacodynamic models  
16:40-17:00 Leonid Gibiansky Methods to detect non-compliance and minimize its impact on population PK parameter estimates  
17:00-17:20 Julie Bertrand Penalized regression implementation within the SAEM algorithm to advance high-throughput personalized drug therapy  
  Social evening


Friday June 14


09:00-10:00 Development and application of models in oncology chair: Marylore Chenel
09:00-09:20 Shelby Wilson Modeling the synergism between the anti-angiogenic drug sunitinib and irinotecan in xenografted mice  
09:20-09:40 Amy Cheung Using a model based approach to inform dose escalation in a Ph I Study by combining emerging clinical and prior preclinical information: an example in oncology  
09:40-10:00 Sonya Tate Tumour growth inhibition modelling and prediction of overall survival in patients with metastatic breast cancer treated with paclitaxel alone or in combination with gemcitabine
10:00-10:10 Preview of PAGE 2014
10:10-10:50 Coffee break
10:50-12:10 Stuart Beal methodology session chair: Steve Duffull
10:50-11:10 Chuanpu Hu Latent variable indirect response modeling of continuous and categorical clinical endpoints  
11:10-11:30 Anne-Gaelle Dosne Application of Sampling Importance Resampling to estimate parameter uncertainty distributions  
11:30-11:50 Hoai Thu Thai Bootstrap methods for estimating uncertainty of parameters in mixed-effects models  
11:50-12:10 Celia Barthelemy New methods for complex models defined by a large number of ODEs: application to a glucose/insulin model  
12:10-12:20 Closing remarks
12:20-12:40 Audience input for the PAGE 2014 program