Calvagone
On June 3rd Calvagone will be running a 1-day workshop on e-Campsis, an intuitive web application to set-up and run PK/PD & QSP simulations, and to communicate simulation results in an interactive way.
As a participant you will get free access to e-Campsis pro. You will learn how to:
- Import a model from various sources (Campsis, model library, NONMEM)
- Set up a trial design
- Bootstrap covariates from an external source (e.g. NHANES)
- Explore what-if scenarios thanks to the built-in scenario creator
- Stratify and visualize the results with customizable plots
- Post-process the results, derive useful metrics and summary statistics and generate HTML tables in a few clicks
- Overlay external data on top of simulations
- Create forest plots in an intuitive manner to assess the impact of covariates
- Make a sensitivity analysis effortlessly and understand the limitations of your model
You will also learn how to reproduce the simulations offline in R thanks to the open-source package campsis.
The following registration fee applies for this 1-day workshop:
Industry: € 200 (100*) excl. VAT
Academic: € 100 (50*) excl. VAT
Student: € 100 (50*) excl. VAT
*Register and pay before April 1st to get a 50% early bird discount!
The fee includes the workshop material, lunch and coffee breaks as well as temporary access to e-Campsis pro for 3 months.
Only limited knowledge of R is required, since all hands-on exercises will be done in the web application. Participants should bring their own laptop.
The course will take place at Hotel Capsis 4* https://capsishotels.gr/en - 400 m from the metro station of Dimokratias.
Please click on the link below to register.
https://forms.office.com/e/tUjcgxChzM
PS: If you already want to familiarize yourself with e-Campsis before the workshop, feel free to explore the free version at https://www.e-campsis.com.
Educational Pharmacometrics Summer Symposium
The fourth Educational Pharmacometrics Summer Symposium (EPSS) will take place on 3 June 2025, close to the PAGE venue (here). This free one-day symposium will bring together experts and professionals in the field of pharmacometrics (PMx) to give an overview of what pharmacometrics is and how it can contribute to model-informed drug development and therapy individualisation. The symposium is an excellent opportunity to gain valuable knowledge about PMx, PMx-related career possibilities, establish professional relationships, and present your work.
The symposium will begin with a brief introduction to PMx, followed by a discussion on the use of PMx in drug development, covering preclinical and clinical applications. After lunch and networking, the use of PMx to optimise and personalise treatment, will be presented, followed by PMx case studies, which will be based on submitted student abstracts. The symposium will conclude with a short group work session.
The symposium is intended for MSc/PhD students from all natural sciences, postdocs, and others with an interest in pharmacometrics, such as, clinical pharmacists, clinicians, mathematicians, statisticians, or colleagues from industry.
Students/postdocs may apply to present their original PMx-related work as a part of the symposium (submitted abstract should not exceed 4,500 characters, including spaces, and may be the same as for the PAGE 2025 meeting); abstract submission deadline is 4 May 2025.
The participation is free of charge. Light lunch will be provided. Based on last years’ positive feedback, register early to avoid missing out: link (open until 4 May 2025). For more information, please email 4thEPSS2025@gmail.com.
This event is supported by Boehringer Ingelheim, Pharmetheus and National and Kapodistrian University of Athens.
ICON
Advanced Features of NONMEM 7 Workshop for PAGE 2025
Date: Monday, 2nd June, 2025
Time: 09:00 - 17:00
Location: Thessaloniki | Greece
Timezone: (GMT +1:00) Central European Time
A one-day in person NONMEM 7 course will be presented by ICON at the PAGE 2025 Conference
A one-day NONMEM 7.6 course will be presented by ICON at the PAGE 2024 Conference. This one-day, in-person, workshop will cover the description and use of features in NONMEM 7. Workshop attendees will be instructed how to specify gradient precision and how to use the FAST algorithm (new in NM 7.4) for FOCE and will also be instructed on how to use the Monte Carlo importance sampling, stochastic approximation expectation-maximization methods, and full Bayesian methods such as Gibbs sampling and Hamiltonian no-U turn sampling (new in NM 7.4). Parallel computing and dynamic memory allocation for efficient memory usage will also be described as well as symbolic references to thetas, etas, and sigmas, priors to sigmas, MonteCarlo search algorithms to improve FOCE estimation, built-in individual weighted residuals, bootstrap tools for simulation, and automatic stabilization against numerical exceptions. Also, learn to use new abbreviated code features for easier modeling of inter-occasion variability, modelling additional mixed effects levels for grouping individuals, such as inter-clinical site variability, and using the DO loop feature in abbreviated code, useful for handling multiple bolus doses in models that use the analytical absorption function for multiple transit compartments. New in NONMEM 7.5: Optimal clinical design and evaluation tool is available, as well as delay differential equation solvers.
Presenters: Robert Bauer, PhD,Brian Sadler, PhD, and Mohamed Ismail, PharmD/MS.
For additional information and agenda, please go to Workshop: Advanced NONMEM 7.6 (iconplc.com)
Fees: $600 for Industry, $300 for Academia/Government, $150 for Students
For more information and registration, contact Andreea Ancuta at IDSSOFTWARE@iconplc.com
Simcyp Workshop - Designer Workshop
Tutors: Abdallah Derbalah abdallah.derbalah@certara.com & Tariq Abdulla tariq.abdulla@certara.com
Date: 3rd June 2025
Time: 08:30 – 16:30
AudioVisual Equipment: Projector, Screen, white board, power to each table (rounds)
Number of participants: Minimum 6 / Maximum 20
Food and Beverage needs: Mid morning Break / light lunch / Afternoon break
Course Title: A Hands-On Workshop with Simcyp Designer for Tailored PBPK-PD/QSP Models
Would you like to modify and tailor population PBPK models? This course will review the principles of PBPK modelling, using the Simcyp Simulator and how to use Simcyp Designer to modify existing PBPK models with your own extension and link them to custom-built PD/QSP models. We will have lectures to introduce the PBPK models to be changed and have hands-on exercises to train the customisation of PBPK models with the Designer. No prior knowledge is required. Access to the Simcyp Simulator and Simcyp Designer will be provided. Participant are required to bring their own laptops as the workshop is hands-on intensive.
Key aspects of the course:
- Overview of PBPK modelling, using the Simcyp Simulator.
- Rapidly create new models in a graphical editor – Introduction to Simcyp Designer.
- Replace PBPK model components in Simcyp with a user-defined model.
- Adding components/modules to Simcyp PBPK models.
- Extending PBPK models for large molecules.
- Building PBPK driven PD/QSP models.
- Incorporate population variability into the customized models.
- Combined model parameter estimation and sensitivity analysis
COST £250+VAT Students (Coupon Code: STUDENT25) / £500+VAT Industry
Register Here
Pharmetheus
Pharmetheus workshop: Learn and apply TTE and RTTE modeling with a focus on NONMEM
This one and a half day workshop provides a good understanding of time to event (TTE) and repeated TTE (RTTE) modeling in NONMEM, in theory and practice, by listening to and discussing with leaders from both industry and academia. Learn from key speakers including France Mentré, Lena Friberg, and Nastya Kassir.
Target audiences are students and pharmacometricians with no, or limited, previous experience of TTE/RTTE modeling. After the workshop the attendees will be able to understand, conduct and communicate TTE and RTTE modeling analyses.
Agenda highlights:
- Overview of simulation frameworks, data formatting, graphical exploration, key NONMEM coding techniques and hands-on sessions to appreciate the specificities of TTE/RTTE models in terms of evaluation and diagnostics.
- Advanced insights to NONMEM code; standard and alternative function parameterization, implementation of exposure-response relationships, and estimation of covariate effects.
- Motivation for running survival analysis from a model-informed drug development perspective,
Key speakers: France Mentré, Lena Friberg, Nastya Kassir (free for attendees of previous sessions).
Workshop host: Niclas Jonsson
Workshop tutors:, Jurgen Langenhorst, Félicien Le Louedec, Qing Xi Ooi, and Joakim Nyberg
Secure your spot now — early bird discounts available!
Date:
Monday 2nd of June, 13.00-17.00
Tuesday 3rd of June, 8.00-17.00
Venue:
Thessaloniki, Makdonia Palace Hotel
Fees:
- Commercial/Industry: 950 (750**) EUR excl. VAT.
- Academia/government/non for profit: 500 (400**) EUR excl. VAT.
- Students: 250 (200**) EUR excl. VAT.
**Early bird until 1 April.
For more information and registration visit Pharmetheus.com – Workshop: Learn & apply TTE/RTTE modeling"
Pharmetheus workshop: PBPK Modeling for First-in-Human & DDI with OSP Suite
Do you want to increase your capabilities to support decision making in drug development with PBPK? This two days workshop will teach how to use and leverage the Open Systems Pharmacology (OSP) suite (also known as PK-Sim® and MoBi®) for translational modeling to inform First-in-Human and Drug-Drug interactions (DDI) in the context of recent ICH M15.
We will utilize the standardized and well-established whole body PBPK model provided in PK-Sim® and the open modeling possibilities in MoBi®.
The workshop covers aspects such as:
- The fundamentals in PK-Sim and MoBi
- How to set up a PBPK model in PK-Sim in different species (e.g., Rat, Dog and Monkey)
- How to establish an in-vitro in-vivo relationship using PBPK models
- How to retrieve reference compound files (victims and perpetrators) and enzyme/transporters framework
- How to handle non standard DDI cases, e.g. with including multiple enzymes, transporters or endogenous DDI biomarkers with MoBi
- How to verify, qualify and assess applicability of the models
- How to run simulations to inform First-in Human and DDI study designs
- How to assess model risk and give recommendations towards DDI risk for labelling
Workshop tutors: Tobias Kanacher, Johanna Eriksson, Marylore Chenel
Date:
Monday 2nd of June, 9.00-17.00
Tuesday 3rd of June, 9.00-17.00
Venue:
Thessaloniki, Makedonia Palace Hotel
Fees:
- Commercial/Industry: 1200 (900**) EUR excl. VAT.
- Academia/government/non for profit: 600 (450**) EUR excl. VAT.
- Students: 300 (250**) EUR excl. VAT.
**Early bird until 1 April.
Register now to expand your PBPK expertise - early bird discounts available!
For more information and registration visit Pharmetheus.com – Workshop: PBPK modeling for First-in-Human & DDI
Pharmetheus satellite symposium: Model-Informed Drug Development in Regulatory Interactions- Practical takes on the draft ICH M15 Guideline
We are happy to invite the PAGE audience to an afternoon symposium about the application of Model-Informed Drug Development (MIDD) in regulatory interactions. With the draft ICH M15 guideline on “General principles for model-informed drug development” recently posted for public consultation, there is an unprecedented opportunity for our community to bring MIDD to the next level. The aim of this symposium is to reflect on the current use of MIDD in regulatory interactions and propose practical ideas on how to put the ICH guideline into action. We encourage everyone interested in the application of MIDD to support regulatory interrelations to join, and look forward to your contribution to the discussion on this topic.
The symposium will cover:
- Introduction to MIDD and its regulatory landscape
- Overview of the ICH M15 guidance – facts and interpretations
- Expanded views on MIDD evidence
- Absence of evidence vs. evidence of absence
- Supportive evidence vs. primary evidence
- Risk-based credibility assessment
- Practical use of ICH M15 ‘Table for Assessment of MIDD Evidence’
- Model evaluation in line with the ICH M15 guideline
- Verification, validation, and applicability assessment
- Question of interest focused model diagnostics
- Planning and preparing MIDD for successful regulatory interactions
- Working with interdisciplinary teams
- Efficient processes and proactive work
- Examples of MIDD applications with regulatory impact
Date: Tuesday 3rd of June
Time: 14:00 – 18:00
Venue: Thessaloniki, Makedonia Palace hotel
Fee: 185 (135**) EUR excl. VAT.
**Early bird until 1 April.
For more information and registration visit Pharmetheus.com- Symposium: MIDD in regulatory interactions
Pumas
Workshop 1 : Scientific Modeling Augmented by Machine Learning with DeepPumas
DeepPumas is a powerful tool that bridges the gap between mechanistic, statistical, and machine learning modeling. This hands-on workshop will introduce participants to the core concepts behind DeepPumas and its potential to transform decision-making in the healthcare space. By seamlessly embedding machine learning methodology into nonlinear mixed-effect models, DeepPumas enables the simultaneous utilization of domain-specific knowledge and available data for model identification.
This workshop will give participants practical skills in hybrid mechanistic and machine learning modeling, a comprehension of how complex covariates can help forecast longitudinal outcomes, and an insight into the possible implications of this technology.
Learning Objectives:
- Learn basic usage of the Pumas and DeepPumas software.
- Understand simple neural networks and how to use them.
- Understand neural-embedded dynamical systems such as Neural Ordinary Differential Equations (ODEs) and Universal Differential Equations (UDEs).
- Learn Mixed-Effect Neural Networks (MeNets) and how to find individualizable models.
- Learn how to integrate machine learning for prognostic factor identification in longitudinal models.
- Understand how to compose all the above to enable a semi-mechanistic scientific machine learning approach to finding individualizable and predictive longitudinal models.
- Get a sense of how this technology may transform the role of data and modeling in the healthcare space.
Instructors: Niklas Korsbo, PhD and Patrick Kofod Mogensen, PhD
Click here to register!
Date & Time: Monday, June 2, 2025 | 8AM – 5PM
Tuesday, June 3 , 2025 | 8AM – 5PM
Workshop 2 : Nonlinear Mixed Effects Modeling Workflows using Pumas
This workshop provides a deep dive into Pumas, a powerful pharmacometric platform designed for modeling and simulation in drug development. Participants will gain hands-on experience and knowledge of the standard workflows in population pharmacokinetics (PK) and sequential PKPD modeling. Experts will guide attendees through various stages of model building, diagnostics, and data wrangling, with opportunities to explore specialized areas like absorption models, using non-Gaussian random effects.
Instructors: Andreas Noack, PhD, Vijay Ivaturi, PhD and Patrick Kofod Mogensen, PhD
Click here to register!
Date & Time: Tuesday, June 3 , 2025 | 9AM – 5PM
Simulations Plus
WORKSHOP 1: Introductory Course for Pharmacometrics Modeling using Monolix
1.5 day: June 2nd (9 AM – 5 PM) and June 3rd (9 AM – 12 PM), 2025
Whether you’re a novice in population modeling eager to start working on your PK and PK-PD projects, or an intermediate modeler aiming to boost your confidence and make strategic decisions, this 1.5-day course is tailored for you. Gain essential skills to: develop, diagnose and interpret models, and efficiently use algorithms within Monolix.
The comprehensive course includes practical, hands-on exercises to reinforce your newly acquired knowledge. No prior experience with MonolixSuite is necessary.
- Gain the statistical knowledge essential for understanding the population approach and interpreting results effectively.
- Build complete Monolix projects, covering data visualization, model set up, and parameter estimation.
- Employ various diagnostic tools to assess model goodness of fit and how to improve it.
- Implement complex models and refine strategies for optimal model development.
- Explore Monolix algorithms and their options.
Includes a temporary licence for the MonolixSuite.
REGISTRATION:
https://simulations-plus.learnupon.com/store/4244916-mx102ip-introductory-course-for-pharmacometrics-modeling-using-monolix
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WORKSHOP 2: Advanced Course for Pharmacometrics Modeling using Monolix
1.5 day: June 2nd (9 AM – 5 PM) and June 3rd (9 AM – 12 PM), 2025
Take your modeling skills to the next level with our advanced 1.5-day course on modeling in pharmacometrics using Monolix. Designed for modelers with intermediate knowledge of Monolix, who wish to:
- Deepen understanding: gain insights into the methods and algorithms behind each task and the impact of their settings.
- Implement complex models: learn how to write and diagnose intricate models effectively such as non-standard parameter-covariate relationships or non-continuous data.
- Optimize model building strategies: improve your approach to covariate model building and inter-occasion variability for enhanced outcomes.
This course features both lectures and interactive hands-on sessions with Monolix. A dedicated Q&A session ensures your queries are addressed comprehensively.
Includes a temporary licence for the MonolixSuite.
REGISTRATION:
https://simulations-plus.learnupon.com/store/4248762-mx300ip-advanced-course-for-pharmacometrics-modeling-using-monolix
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WORKSHOP 3: From Simple to Complex Simulations in Pharmacometrics Course using Simulx
0.5 day: June 3rd (1 – 5 PM), 2025
Explore the world of simulations in pharmacometrics with our half-day workshop using Simulx - a simulation tool equipped with a user-friendly graphical interface and fully integrated with all MonolixSuite applications. This training will give you the keys to confidently set up simulation scenarios and efficiently answer “what if” questions.
Learn the ins and outs of simulations:
- Define simulation elements such as outputs, treatments, or covariates.
- Explore your model and effective dosing regimens.
- Simulate groups of individuals and clinical trials with uncertainty.
- Post-process results and analyse efficacy and safety criteria.
- Use statistical tests to answer relevant questions.
Whether you’re starting from scratch or building a simulation based on an existing Monolix project, this training equips you with the essential tools.
Engage in hands-on sessions, progressing from simple to complex examples, to solidify your understanding of simulations and Simulx. Don't miss this opportunity to enhance your skills and navigate pharmacometrics with ease.
Includes a temporary licence for the MonolixSuite.
REGISTRATION
https://simulations-plus.learnupon.com/store/4248773-sx100ip-from-simple-to-complex-simulations-in-pharmacometrics-using-simulx
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WORKSHOP 4: Automating Pharmacometrics modeling and Simulations Course: Scripting using lixoftConnectorsTM
0.5 day: June 3rd (1 – 5 PM), 2025
Discover the potential of workflow automation in pharmacometrics modeling and simulations with our half-day course on using lixoftConnectors. These R-API functions offer direct access to MonolixSuite applications from within R and enable you to seamlessly script complex workflows and revolutionize your approach to pharmacometrics.
What you will discover:
- R-API functions: gain insight into the applications of lixoftConnectors to access MonolixSuite from R.
- Workflow automation: understand the fundamental principles of these functions and how to script modeling and simulation tasks efficiently.
- Integration of MonolixSuite: learn about benefits from the direct connectivity between R and MonolixSuite through lixoftConnectors.
This course is designed for professionals with at least basic knowledge about Monolix and Simulx, who seek to script their pharmacometrics workflows. It features both lectures and interactive hands-on sessions. Join us to unlock the potential of lixoftConnectors to elevate your pharmacometrics projects.
Includes a temporary licence for the MonolixSuite.
REGISTRATION
https://simulations-plus.learnupon.com/store/4248808-mx201ip-automating-pharmacometrics-modeling-and-simulations-scripting-using-lixoftconnectors
Uppsala University
Automated and scripted model development workshop
Date: Tuesday June 3nd 2025
Time: 09:00 - 17:00
Location: Makedonia Palace, room Aristotelis, Thessaloniki, Greece
Fee: Free (lunch is not included)
Registration: Send an email to rikard.nordgren@uu.se. There is a limited number of seats.
Workshop instructors: Dr. Xiaomei Chen, Rikard Nordgren (Systems developer), Stella Belin (Systems developer), Prof. Mats Karlsson, Prof. Andrew Hooker
Pharmpy is an open-source pharmacometric library for automated and scripted model building. By using Pharmpy, you can build pharmacometric workflows in R or Python, including creating and fitting models, parsing modelfit results, and running full tools for automatic model building. This one day course will let participants get familiar with the different functions and tools, as well as some hands-on experience with the software. Pharmpy mainly supports building NONMEM models with some support for building nlmixr models. Please visit https://pharmpy.github.io for more information on the package. A paper was published on the automatic model building tool (https://pubmed.ncbi.nlm.nih.gov/39190006/) and Pharmpy has been presented at previous PAGE conferences (https://www.page-meeting.org/default.asp?abstract=11039).
Contents:
* Background and philosophy of the automatic model building tools
* Scripted model building (including modifying existing NONMEM models and creating models from scratch)
* Automatic model building of the structural, IIV, IOV, RUV and covariate models
* Full automatic model building starting from a dataset (PK, PKPD, drug-metabolite and TMDD models)
* Hands-ons to explore how the tools work
* Insights into the inner workings of the tools
Examples and hands-ons will be using R.