2022 - Ljubljana - Slovenia

2022 - Ljubljana - Slovenia

Thirtieth meeting, 28 June - 1 July, 2022

 

Tuesday

 

       
09:30-17:30 Registration at the conference venue
       
       
19:30-21:30 Welcome reception with drinks and light snacks (no dinner)
       

 

 

Wednesday

 

       
08:00-08:45 Registration at the conference venue
       
       
08:45-09:00 Welcome and introduction

Oscar della Pasqua & Thomas Dorlo

       
09:00-09:45 Keynote lecture

Rocio Lledo-Garcia & Zinnia Parra Guillen

       
09:00-09:45 Iain Gardner Pre-clinical and clinical applications of PBPK models for monoclonal antibodies and other large molecule modalities.
       
09:45-11:15 Coffee break, Poster and Software Session I
       
       
11:15-12:15 Immunogenicity

Rocio Lledo-Garcia & Zinnia Parra Guillen

       
11:15-11:35 Hans Peter Grimm Learn-and-Confirm in Quantitative Systems Pharmacology: Evaluation of an Immunogenicity Platform
       
11:55-12:15 Rory Leisegang Immunogenicity dynamics and covariate effects after satralizumab administration predicted with a Hidden Markov Model
       
11:35-11:55 Alix Demaris Towards understanding anti-infliximab antibody development to predict Crohn’s disease patients' underlying immunogenicity status
       
12:15-13:45 Lunch
       
       
13:45-14:25 Automatic Model Development

Gilbert Koch

       
13:45-14:05 Xiaomei Chen Development of a tool for fully automatic model development (AMD)
       
14:05-14:25 Marc Lavielle SAMBA: a new algorithm for automatic construction of nonlinear mixed-effects models.
       
14:25-15:05 Model-Informed Precision Dosing

Stefanie Hennig & Ana Ruiz

       
14:25-14:45 Ron Keizer Composite Importance Sampling (CIS) for continuous learning in precision dosing
       
14:45-15:05 Benjamin Ribba Population model-enhanced reinforcement learning to enable precision dosing: case study with dosing of propofol for sedation
       
15:05-15:10 Special Announcement
       
       
15:10-16:40 Coffee break, Poster and Software Session II
       
       
16:40-17:20 Modelling Other Pharmacological Aspects

Siv Jönsson & Monica Simeoni

       
16:40-17:00 Orwa Albitar Pharmacometric Modeling of Drug Adverse Effects: An Application of Mixture Models in Schizophrenia Spectrum Disorder Patients Treated with Clozapine
       
17:00-17:20 Jurgen Langenhorst An item response theory model with bounded integer subcomponents to describe the Mayo Clinic subscores in patients with ulcerative colitis

 

 

Thursday

 

       
08:30-09:50 Lewis Sheiner Student Session

Al Maloney, Nadia Terranova & Justin Wilkins

       
08:30-08:55 Kamunkhwala Gausi A semi-mechanistic model of the population pharmacokinetics and bactericidal activity of high-dose isoniazid against multi-drug-resistant tuberculosis
       
08:55-09:20 Yu Fu A translational cardiovascular systems model to quantify drug effects on contractility and other hemodynamic variables
       
09:20-09:45 Soumya Perinparajah Mathematically Modelling CD19+ B Cell Reconstitution After Insult to the Immune System: Paediatric Allogeneic Haematopoietic Stem Cell Transplantation, Rituximab Therapy and Epstein-Barr Viral Reactivation
       
09:45-09:50 Presentation Lewis Sheiner Student Session Awards
       
       
09:50-11:20 Coffee break, Poster and Software session III
       
       
11:20-12:40 Infectious Diseases: SARS-CoV-2 & Tuberculosis

Thomas Dorlo & France Mentré

       
11:20-11:40 Marie Alexandre SARS-CoV-2 mechanistic correlates of protection in non-human primates: insight from modelling response to vaccines.
       
11:40-12:00 Alexandra Lavalley-Morelle Longitudinal biomarkers predicting death of hospitalized patients for SARS-COV-2 infection: a joint analysis with competing risks
       
12:00-12:20 Jacqueline Ernest Spatially and temporally resolved diffusion kinetics of bedaquiline and TBAJ-587 in hard-to-treat sites of TB disease
       
12:20-12:40 Federico Reali PBPK/PD modeling and machine learning approaches to support the development of new drugs and regimens against tuberculosis.
       
12:40-12:45 ACoP Announcement

Anja Henningsson & Ana Ruiz

       
12:45-14:15 Lunch
       
       
14:15-15:00 Keynote Lecture

Oscar Della Pasqua

       
14:15-15:00 Filippo Castiglione Modeling biology by agents
       
15:00-16:30 Coffee break, Poster, and Software Session IV
       
       
16:30-17:30 Stuart Beal Methodology Session

Emmanuelle Comets & Martin Bergstrand

       
16:30-16:50 Sarah Baklouti A methodology to de-shrink Empirical Bayes Estimates
       
16:50-17:10 Thomas Bouillon Dose selection by covariate assessment on the optimal dose for efficacy – application of machine learning in the context of PKPD
       
17:10-17:30 Laura Zwep Copula modeling for realistic virtual patient covariate simulation
       
20:00-00:00 Social Event
       

 

 

Friday

 

       
09:15-10:35 Oncology

Dinesh de Alwis & Rene Bruno

       
09:15-09:35 Zinnia Parra-Guillen A physiologically-based pharmacokinetic/pharmacodynamic framework to support clinical development of V937, a novel oncolytic virus
       
09:35-09:55 Marion Kerioui Joint modelling of individual target lesions and survival to characterize the variability in the response to immunotherapy versus chemotherapy in advanced bladder cancer
       
09:55-10:15 Sebastien Benzekry Supporting decision making and early prediction of survival for oncology drug development using a pharmacometrics-machine learning based model.
       
10:15-0:35 Sarah Lobet Target-response relationship of bevacizumab may be more relevant than exposure-response - a target-mediated drug disposition (TMDD) model
       
10:35-10:40 Preview of PAGE 2023
       
       
10:40-11:15 Coffee break
       
       
11:15-11:55 Real-World Data in Oncology

Pascal Girard

       
11:15-11:35 Perrine Courlet Modelling real-world tumor size dynamics based on electronic health records and image data in advanced melanoma patients receiving immunotherapy
       
11:35-11:55 Luca Marzano Introducing a novel analytical framework for risk stratification of real-world data with survival and unsupervised machine learning. A small cell lung cancer SCLC study
       
11:55-12:05 Closing Remarks

Oscar Della Pasqua

       
12:05-12:20 Audience input for PAGE 2023 Scientific Programme

Chair: Thomas Dorlo

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