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Thursday
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| 13:00-13:10 |
Welcome and introduction |
Oscar Della Pasqua & Dinesh de Alwis
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| 13:10-14:40 |
Keynote Lectures COVID-19 |
Chairs: Oscar Della Pasqua & Lutz Harnisch
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| 13:10-13:55 |
France Mentré |
Pharmacometrics to support clinical investigation during COVID-19 pandemics |
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| 13:10-13:55 |
Jeremie Guedj |
Pharmacometrics to support clinical investigation during COVID-19 pandemics : a viral dynamics perspective |
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| 13:55-14:40 |
Thorsten Lehr |
Modeling and Simulation of SARS-CoV-2 Infections, Hospitalizations and Outcome in Germany |
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| 14:40-15:40 |
Social break |
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| 15:40-15:45 |
PAGE scientific program |
Thomas Dorlo
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| 15:45-16:45 |
Pharmacometrics to advance management and prevention of COVID-19 |
Chairs: France Mentre & Oscar Della Pasqua
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| 15:45-16:05 |
Nadege Neant |
Modeling SARS-CoV-2 viral kinetics in hospitalized patients |
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| 16:05-16:25 |
Mélanie Prague |
Using population approach to model COVID-19 epidemics in France: estimating the burden of SARS-Cov-2 and the effects of non-pharmaceutical interventions. |
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| 16:25-16:45 |
Seth Robey |
Predictive Primates: Enabling Rapid Go/No-Go Decisions on COVID-19 Vaccine Candidates with a Predictive, Translational MBMA and Clinical Immunogenicity Data |
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| 16:45-16:55 |
Break |
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| 16:55-17:40 |
Tutorial |
Chairs: Thomas Dorlo & Lutz Harnisch
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| 16:55-17:10 |
Andrew Hooker |
Tutorial on survival analysis and its application to the assessment of competing risks in clinical data analysis. |
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| 17:10-17:40 |
Joachim Grevel |
Tutorial on application of survival analysis to the assessment of multiple state models in clinical data analysis. |
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| 17:40 |
Day End |
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Friday
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| 12:00-13:00 |
Poster Session I |
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| 13:00-14:20 |
Lewis Sheiner Student Session 2020 |
Chairs: Rocio Lledo-Garcia & Monica Simeoni
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| 13:00-13:25 |
Rob van Wijk |
Translational quantitative systems pharmacology; crossing borders between experimental and computational drug development using zebrafish as model organism |
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| 13:25-13:50 |
Eleni Karatza |
Machine-Learning for cancer treatment: Guided covariate selection for TTE models developed from real world data with a small number of patients |
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| 13:50-14:15 |
Vincent Chang |
In silico assessment of adaptive trial design for TB regimen development |
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| 14:15-14:20 |
Presentation Lewis Sheiner Student Session Awards 2020 |
Rocio Lledo-Garcia & Monica Simeoni
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| 14:20-14:30 |
Announcement WCOP 2022 |
Paolo Denti & Stacey Tannenbaum
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| 14:30-15:30 |
Social Break |
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| 15:30-16:45 |
Lewis Sheiner Student Session 2021 |
Chairs: Juan Jose Perez-Ruixo, Stacey Tannenbaum, Kayode Ogungbenro
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| 15:30-15:55 |
Linda Aulin |
Model-based design of innovative treatment strategies to suppress antimicrobial resistance using collateral sensitivity |
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| 15:55-16:20 |
Marion Kerioui |
Bayesian modelling of individual lesions dynamics and survival to characterize response to immunotherapy cancer treatments |
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| 16:20-16:45 |
Anna Mc Laughlin |
Population quantitative systems pharmacology model of distinct CAR-T cell phenotypes and CD19-specific metabolic tumour volume reveals sources of high pharmacokinetic variability and overall survival |
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| 16:45-16:50 |
Presentation Lewis Sheiner Student Session Awards 2021 |
Juan Jose Perez-Ruixo, Stacey Tannenbaum, Kayode Ogungbenro
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| 16:50-17:00 |
Break |
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| 17:00-17:40 |
Stuart Beal Methodology Session I |
Chair: Martin Bergstrand
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| 17:00-17:20 |
Alexander Janssen |
The Neural Mixed Effects algorithm: leveraging machine learning for pharmacokinetic modelling |
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| 17:20-17:40 |
James Lu |
Deep Learning for PK/PD and Disease Progression Time-Course Predictions using Neural-ODE |
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| 17:40 |
Day End |
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Monday
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| 12:00-13:00 |
Poster Session II |
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| 13:00-13:45 |
Keynote Lecture |
Chair: Benjamin Ribba
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| 13:00-13:45 |
Vladimir Dragalin |
Adaptive trial designs: opportunities and challenges |
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| 13:45-13:50 |
Break |
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| 13:50-15:00 |
Oncology-dedicated to Laurent Claret |
Chairs: René Bruno, Pascal Girard, Panos Macheras
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| 13:50-14:00 |
In Memoriam Laurent Claret |
René Bruno
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| 14:00-14:20 |
Anyue Yin |
Anti-cancer treatment schedule optimization based on tumor dynamics modelling incorporating evolving resistance |
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| 14:20-14:40 |
Sreenath M Krishnan |
Multistate model for pharmacometric analyses of overall survival in anticancer treatments |
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| 14:40-15:00 |
René Bruno |
Operating characteristics of tumor growth inhibition-overall survival models to support early Phase Ib decisions: An evaluation in first-line metastatic non-small cell lung cancer patients treated with atezolizumab plus chemotherapy based on the Phase III study IMpower150 |
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| 15:00-16:00 |
Social Break |
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| 16:00-17:00 |
Integrating machine learning & quantitative pharmacology |
Chairs: Marylore Chenel & Justin Wilkins
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| 16:00-16:20 |
Verena Gotta |
Personalizing hemodialysis (HD) treatment in pediatric patients with end-stage renal disease (ESRD) – application and integration of quantitative pharmacology with machine learning |
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| 16:20-16:40 |
Jasmine Hughes |
A hybrid machine learning/pharmacokinetic approach improves predictive performance in model-informed precision dosing |
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| 16:40-17:00 |
Diego Vera |
Semi-mechanistic modeling of tumor size and overall survival including machine learning-derived tumor heterogeneity |
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| 17:00-17:05 |
Break |
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| 17:05-17:45 |
Improving decision making in drug development and clinical care |
Chair: Ana Ruiz
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| 17:05-17:25 |
Nicolás Marco Ariño |
The broad use of pharmacometrics in patient care: the case of blood transfusion and perioperative management |
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| 17:25-17:45 |
Estelle Yau |
A systematic framework for the incorporation of preclinical species data into physiologically-based pharmacokinetic models using a middle-out approach to improve the translation of drug distribution in humans |
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| 17:45 |
Day End |
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Tuesday
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| 12:00-13:00 |
Poster Session III |
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| 13:00-14:00 |
Stuart Beal Methodology Session II |
Chair: France Mentre
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| 13:00-13:20 |
Carolina Llanos-Paez |
Use of item-based non-linear mixed effects model to improve confidence in Phase III clinical trial decision-making |
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| 13:20-13:40 |
Iris Minichmayr |
Beyond disease progression – Item response theory modelling to gain structural insights into disease facets underlying clinical score assessments |
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| 13:40-14:00 |
Alexandra Lavalley-Morelle |
Individual dynamic predictions in joint analysis for nonlinear marker evolution and competing risk data: application on patients admitted in Intensive Care Unit for sepsis |
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| 14:00-14:20 |
Break |
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| 14:20-15:30 |
Bacterial Diseases |
Chairs: Stephan Schmidt & Charlotte Kloft
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| 14:20-14:30 |
In Memoriam Hartmut Derendorf |
Stephan Schmidt
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| 14:30-14:50 |
Zoe Kane |
Development of a neonatal plasma and cerebrospinal fluid (CSF) population PK model for fosfomycin. |
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| 14:50-15:10 |
David Busse |
Body composition and drug exposure in adipose tissue are key for antibiotic dose-individualisation in obese individuals |
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| 15:10-15:30 |
Jérémy Seurat |
Combination of in vivo phage therapy data with in silico model highlights key parameters for treatment efficacy |
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| 15:30-16:15 |
Social Break |
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| 16:15-17:15 |
Other infectious & Neurological Diseases |
Chair: Lena Friberg
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| 16:15-17:35 |
Roeland Wasmann |
A pharmacometric approach to optimise Fixed-Dose Combinations of Rifampicin, Isoniazid, and Pyrazinamide for children with tuberculosis |
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| 16:35-16:55 |
Marie Alexandre |
Dynamics of the humoral immune response to a two-dose heterologous vaccine regimen against Ebola virus. |
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| 16:55-17:15 |
João Abrantes |
Model-informed development of RG6102, an amyloid-targeting investigational drug with enhanced brain penetration properties |
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| 17:15-17:25 |
Closing Remarks |
Oscar Della Pasqua & Iztok Grabnar
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| 17:25-17:40 |
Audience Input PAGE 2022 |
Thomas Dorlo
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