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Lewis Sheiner

Stockholm, Sweden

Montreux, Switzerland

Budapest, Hungary

Lisboa, Portugal

Hersonissos, Crete, Greece

Alicante, Spain

Glasgow, Scotland

Venice, Italy

Athens, Greece

Berlin, Germany

St. Petersburg, Russia

Marseille, France

KÝbenhavn, Denmark

Brugge/Bruges, Belgium

Pamplona, Spain

Uppsala, Sweden

Verona, Italy

Paris, France

Basel, Switzerland

Salamanca, Spain

Saintes, France

Wuppertal, Germany

Glasgow, Scotland

Sandwich, UK

Frankfurt, Germany

Greenford, UK

Paris, France

Basel, Switzerland

Printable version


Tuesday 6 June


14:00-18:00 Registration at the Conference Venue
19:00-22:00 Opening ceremony, welcome reception and dinner


Wednesday 7 June


08:00-08:45 Registration
08:45-09:00 Welcome and Introduction
09:00-10:30 Benefit-risk profile of medicinal products

Chair: Oscar Della Pasqua

09:00-09:30 Praveen Thokala Overview and implementation of multi criteria decision analysis (MCDA) for benefit-risk assessment
09:30-10:00 Andreas Kouroumalis European regulatory views on benefit-risk assessment methodologies - role of MCDA and other model-based approaches
10:00-10:30 Kevin Marsh Current practices and gaps in benefit-risk assessment: opportunities for combining MCDA with model-based approaches
10:30-12:00 Coffee break, Poster and Software session I
  Posters in Group I (with poster numbers starting with I-) are accompanied by their presenter
12:00-12:40 Benefit-risk profile of medicinal products, continued

Chair: Mats Karlsson

12:00-12:20 Neeraj Gupta Model-Informed Drug Development (MIDD) for ixazomib, an oral proteasome inhibitor
12:20-12:40 Nadia Terranova Simulation analysis of absolute lymphocytes counts (ALC) and relapse rate (RR) following cladribine (re-)treatment rules in subjects with relapsing-remitting multiple sclerosis (RRMS)
12:40-12:45 Announcement for ACoP8 (2017)

Jin Jin

12:45-14:10 Lunch
14:10-15:10 Scaling of PD in paediatrics

Chair: Lutz Harnisch

14:10-14:50 Joseph Standing Scaling pharmacodynamics in children: Lessons from immunology, infectious diseases and critical care
14:50-15:10 Nick Holford Scaling renal function in neonates and infants to describe the pharmacodynamics of antibiotic nephrotoxicity
15:10-16:40 Tea break, Poster and Software session II
  Posters in Group II (with poster numbers starting with II-) are accompanied by their presenter
16:40-17:20 Study design

Chair: Marylore Chenel

16:40-17:00 Hanna Silber Baumann Using pharmacokinetic simulation to guide dose escalation decisions for targeted IL2v immunocytokines
17:00-17:20 Simon Buatois Modelling approaches in dose finding clinical trial: Simulation-based study comparing predictive performances of model averaging and model selection
17:20-18:00 Oncology

Chair: Dinesh de Alwis

17:20-17:40 Yuri Kheifetz Model-based individual managing of thrombocytopenia during multi-cyclic chemotherapy
17:40-18:00 Jurgen Langenhorst High exposure to fludarabine in conditioning prior to allogeneic hematopoietic cell transplantation predicts impaired CD4 reconstitution and lower probability of survival


Thursday 8 June


08:30-09:50 Lewis Sheiner Student Session

Chair: Kristin Karlsson, Julia Winkler, Paolo Magni

08:30-08:55 Elisa Borella Paediatric trial design optimization using prior knowledge in combination with modelling & simulations
08:55-09:20 John Diep Host-Pathogen interactions: A mechanism-based disease progression model to describe the pathogenesis of Acinetobacter baumannii pneumonia
09:20-09:45 Morris Muliaditan Model-based rationale for drug combinations in tuberculosis
09.45-09.50 Presentation of Lewis Sheiner student session awards
09:50-11:20 Coffee break, Poster and Software session III
  Posters in Group III (with poster numbers starting with III-) are accompanied by their presenter
11:20-12:20 Estimation methods

Chair: France Mentré

11:20-12:00 Tutorial
11:20-12:00 Robert Leary An overview of non-parametric estimation methods used in population analysis
12:00-12:20 Mats Karlsson A comparison of performance between parametric and nonparametric estimation for nonlinear mixed-effects models
12:20-12:25 Announcement for WCoP 2020

Stacey Tannenbaum

12:25-13:45 Lunch
13:45-14:45 European regulatory issues

Chair: Susan Cole & Frederike Lentz

13:45-14:15 Kristin Karlsson Regulatory pharmacometrics in the EU in practice and the role of the Modelling and Simulation Working Group
14:15-14:45 Anna Nordmark The new draft EMA Guidance on PBPK – The qualification of the intended use concept
14:45-16:15 Tea break, Poster and Software session IV
  Posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter
16:15-17:40 Stuart Beal Methodology Session dedicated to the memory of Matt Hutmacher

Chair: Emmanuelle Comets & Siv Jönsson

16:15-16:20   In memoriam Matt Hutmacher
16:20-16:40 Wojciech Krzyzanski Correction of the likelihood function as an alternative for imputing missing covariates
16:40-17:00 Henrik Bjugård Nyberg SADDLE_RESET: more robust parameter estimation with a check for local practical identifiability
17:00-17:20 Dmitry Onishchenko Joint modeling of overall survival and tumor size dynamics in non-small cell lung cancer: Clinical trial simulations and validation of predictions at study and subject levels
17:20-17:40 Eva Germovsek Handling frequent observations of composite scores: Application to PROs in COPD
19:00-01:00 Social event


Friday 9 June


09:00-10:00 Systems pharmacology

Chair: Anna Nordmark & Siv Jönsson

09:00-09:20 Markus Krauß Translational systems pharmacology for acquisition of knowledge and prediction of drug pharmacokinetics across patient populations
09:20-09:40 Robin Michelet PBPK modeling of propofol using the middle out approach
09:40-10:00 Miro Eigenmann Therapeutic antibody concentrations at the biophase
10:00-10:25 Modelling experience!

Chair: Katya Gibiansky

10:00-10:25 Alan Maloney The 6 biggest pharmacometrics modelling mistakes!
10.25-10.30 Preview of PAGE 2018
10:30-11:15 Coffee break and Software session
11:15-12:15 Infection

Chair: Lena Friberg

11:15-11:35 Richard Höglund Pharmacokinetic-pharmacodynamic modelling of artesunate in patients with drug resistant and sensitive malaria
11:35-11:55 Salvatore D'Agate Model-based screening of compounds for the treatment of Chagas disease, a neglected tropical disease
11:55-12:15 Carolina Llanos-Paez Balancing efficacy and reduction in renal function to optimize initial gentamicin dosing in children with cancer
12.15-12.25 Closing remarks
12:25-12:40 Audience input for potential PAGE2018 topics