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Lewis Sheiner

Stockholm, Sweden

Montreux, Switzerland

Budapest, Hungary

Lisboa, Portugal

Hersonissos, Crete, Greece

Alicante, Spain

Glasgow, Scotland

Venice, Italy

Athens, Greece

Berlin, Germany

St. Petersburg, Russia

Marseille, France

KÝbenhavn, Denmark

Brugge/Bruges, Belgium

Pamplona, Spain

Uppsala, Sweden

Verona, Italy

Paris, France

Basel, Switzerland

Salamanca, Spain

Saintes, France

Wuppertal, Germany

Glasgow, Scotland

Sandwich, UK

Frankfurt, Germany

Greenford, UK

Paris, France

Basel, Switzerland

Printable version

Tuesday June 5
14:00-18:00 Registration
18:00-20:00 Opening ceremony and welcome reception

Wednesday June 6
08:00-08:40 Registration
08:40-08:55 Welcome and introduction
08:55-09:00 In memoriam Hans Schaefer
09:00-10:15 Panel discussion: modelling and simulation and the regulatory process

chair: Joachim Grevel

  Panel members: Terry Shepard, Gerard Pons, Peter Milligan, Mick Looby, Leon Aarons, Nick Holford
10:15-11:45 Coffee break, poster and software session I
  Posters in Group I (with poster numbers starting with I-) are accompanied by their presenter
11:45-12:25 Model-based evaluations chair: Charlotte Kloft
11:45-12:05 Bruno Bieth Model-based analyses for pivotal decisions, with an application to equivalence testing for biosimilars
12:05-12:25 Sylvain Goutelle A unified in vivo modeling approach for quantitative prediction of the impact of gene polymorphism and drug interactions on drug exposure  
12:25-12:30 Launch of the new journal 'CPT: Pharmacometrics & Systems Pharmacology' speaker: France Mentré
12:30-12:35 The International Society of Pharmacometrics speaker: Marc Pfister
12:35-12:40 The World Conference on Pharmacometrics (WCoP) speaker: Kyungsoo Park
12:40-14:05 Lunch
14:05-14:55 The placebo response chair: Oscar Della Pasqua
14:05-14:55 Fabrizio Benedetti Tutorial: The neurobiology of placebos
14:55-15:15 Jakob Ribbing Literature Model for FEV1 in COPD Trials – Separating the Dynamic Components of Placebo Effect, Disease Progression and Interacting Drug Effects  
15:15-16:45 Tea break, poster and software session II
  Posters in Group II (with poster numbers starting with II-) are accompanied by their presenter
16:45-17:45 Glucose and hemoglobin modelling chair: Nick Holford
16:45-17:05 Thomas Eissing A physiologically-based PK/PD model to capture population variability for diabetes research and automatic blood glucose control
17:05-17:25 Maria Kjellsson Predicting late-phase outcome from early-phase findings using a Model-Based Approach – Application to Type 2 Diabetes Mellitus
17:25-17:45 Franziska Schädeli Stark Semi-physiologic population PKPD model characterizing the effect of bitopertin (RG1678) glycine reuptake inhibitor on hemoglobin turnover in humans

Thursday June 7
08:45-10:05 Oncology

chair: René Bruno

08:45-09:05 James Yates Applying mechanistic pharmacokinetic-pharmacodynamic models (PKPD) to describe the growth and inhibition of xenograft tumours in rats and mice by targeted anti-cancer agents
09:05-09:25 Ben-Fillippo Krippendorff Relationship between the dose of therapeutic antibodies and the inhibition of cytoplasmic and nuclear growth factor signalling
09:25-09:45 Mélanie Wilbaux Population K-PD joint modelling of tumor size and CA 125 kinetics after chemotherapy in relapsed ovarian cancer (ROC) patients
09:45-10:05 Ekaterina Gibiansky PK/PD modeling and optimization of eltrombopag dose and regimen for treatment of chemotherapy-induced thrombocytopenia (CIT) in cancer patients
10:05-11:35 Coffee break, poster and software session III
  Posters in Group III (with poster numbers starting with III-) are accompanied by their presenter
11:35-12:30 Lewis Sheiner student session chairs: Dinesh Dealwis, Katya Gibiansky, Pascal Girard
11:35-12:00 Thomas Dorlo Translational pharmacokinetic modelling and simulation for the assessment of duration of contraceptive cover after use of miltefosine for the treatment of visceral leishmaniasis
12:00-12:25 Sebastian Ueckert Application of Item Response Theory to ADAS-cog Scores Modelling in Alzheimer’s Disease
12:25-12:30 Presentation of awards  
12:30-14:00 Lunch
14:00-15:00 Markov modelling chair: Lutz Harnisch
14:00-14:40 Mats Karlsson Tutorial: Introduction to Markov modelling
14:40-15:00 Oliver Ackaert A hidden Markov model to assess drug-induced sleep fragmentation
15:00-16:30 Tea break, poster and software session IV
  Posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter
16:30-17:30 Stuart Beal methodology session chair: France Mentré
16:30-16:50 Chee Ng Novel Hybrid Artificial Neural Network-Nonlinear Mixed Effect Model Modeling Approach for Population Data Analysis in Model-based Drug Development
16:50-17:10 William Denney N-dimensional Likelihood Profiling: An Efficient Alternative to Bootstrap
17:10-17:30 Gilbert Koch Modeling of delayed phenomena in PKPD by delay differential equations of lifespan type
  Social evening

Friday June 8
09:00-10:15 Lumping and identifiability chair: Leon Aarons
09:00-09:35 Aris Dokoumetzidis Tutorial: Lumping of compartments
09:35-09:55 Jin Jin Model-Based Meta-Analysis for the Efficacy and Safety of Paclitaxel in Cancer Patients
09:55-10:15 Yasunori Aoki A practical algorithm for practical parameter identifiability analysis
10:15-10:25 Preview of PAGE 2013
10:25-10:55 Coffee break
10:55-12:15 Variability models and optimal design chair: Marylore Chenel
10:55-11:15 Anne-Gaelle Dosne A strategy for residual error modeling incorporating both scedasticity of variance and distribution shape
11:15-11:35 Ron Keizer Extended NPDE diagnostics for the between-subject variability and residual error model
11:35-11:55 Camille Vong Handling Below Limit of Quantification Data in Optimal Trial Design
11:55-12:15 France Mentré Survey on the current use of optimal design approaches and the developments needed in adaptive optimal design for model based analysis performed amongst DDMoRe’s EFPIA members
12:15-12:25 Closing remarks
12:25-12:40 Audience input for the PAGE 2013 program