2012 - Venice - Italy

2012 - Venice - Italy

Tuesday June 5
14:00-18:00 Registration
18:00-20:00 Opening ceremony and welcome reception

Wednesday June 6
08:00-08:40 Registration
08:40-08:55 Welcome and introduction
08:55-09:00 In memoriam Hans Schaefer
09:00-10:15 Panel discussion: modelling and simulation and the regulatory process

chair: Joachim Grevel

  Panel members: Terry Shepard, Gerard Pons, Peter Milligan, Mick Looby, Leon Aarons, Nick Holford
10:15-11:45 Coffee break, poster and software session I
  Posters in Group I (with poster numbers starting with I-) are accompanied by their presenter
11:45-12:25 Model-based evaluations chair: Charlotte Kloft
11:45-12:05 Bruno Bieth Model-based analyses for pivotal decisions, with an application to equivalence testing for biosimilars
12:05-12:25 Sylvain Goutelle A unified in vivo modeling approach for quantitative prediction of the impact of gene polymorphism and drug interactions on drug exposure  
12:25-12:30 Launch of the new journal 'CPT: Pharmacometrics & Systems Pharmacology' speaker: France Mentré
12:30-12:35 The International Society of Pharmacometrics speaker: Marc Pfister
12:35-12:40 The World Conference on Pharmacometrics (WCoP) speaker: Kyungsoo Park
12:40-14:05 Lunch
14:05-14:55 The placebo response chair: Oscar Della Pasqua
14:05-14:55 Fabrizio Benedetti Tutorial: The neurobiology of placebos
14:55-15:15 Jakob Ribbing Literature Model for FEV1 in COPD Trials – Separating the Dynamic Components of Placebo Effect, Disease Progression and Interacting Drug Effects  
15:15-16:45 Tea break, poster and software session II
  Posters in Group II (with poster numbers starting with II-) are accompanied by their presenter
16:45-17:45 Glucose and hemoglobin modelling chair: Nick Holford
16:45-17:05 Thomas Eissing A physiologically-based PK/PD model to capture population variability for diabetes research and automatic blood glucose control
17:05-17:25 Maria Kjellsson Predicting late-phase outcome from early-phase findings using a Model-Based Approach – Application to Type 2 Diabetes Mellitus
17:25-17:45 Franziska Schädeli Stark Semi-physiologic population PKPD model characterizing the effect of bitopertin (RG1678) glycine reuptake inhibitor on hemoglobin turnover in humans

Thursday June 7
08:45-10:05 Oncology

chair: René Bruno

08:45-09:05 James Yates Applying mechanistic pharmacokinetic-pharmacodynamic models (PKPD) to describe the growth and inhibition of xenograft tumours in rats and mice by targeted anti-cancer agents
09:05-09:25 Ben-Fillippo Krippendorff Relationship between the dose of therapeutic antibodies and the inhibition of cytoplasmic and nuclear growth factor signalling
09:25-09:45 Mélanie Wilbaux Population K-PD joint modelling of tumor size and CA 125 kinetics after chemotherapy in relapsed ovarian cancer (ROC) patients
09:45-10:05 Ekaterina Gibiansky PK/PD modeling and optimization of eltrombopag dose and regimen for treatment of chemotherapy-induced thrombocytopenia (CIT) in cancer patients
10:05-11:35 Coffee break, poster and software session III
  Posters in Group III (with poster numbers starting with III-) are accompanied by their presenter
11:35-12:30 Lewis Sheiner student session chairs: Dinesh Dealwis, Katya Gibiansky, Pascal Girard
11:35-12:00 Thomas Dorlo Translational pharmacokinetic modelling and simulation for the assessment of duration of contraceptive cover after use of miltefosine for the treatment of visceral leishmaniasis
12:00-12:25 Sebastian Ueckert Application of Item Response Theory to ADAS-cog Scores Modelling in Alzheimer’s Disease
12:25-12:30 Presentation of awards  
12:30-14:00 Lunch
14:00-15:00 Markov modelling chair: Lutz Harnisch
14:00-14:40 Mats Karlsson Tutorial: Introduction to Markov modelling
14:40-15:00 Oliver Ackaert A hidden Markov model to assess drug-induced sleep fragmentation
15:00-16:30 Tea break, poster and software session IV
  Posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter
16:30-17:30 Stuart Beal methodology session chair: France Mentré
16:30-16:50 Chee Ng Novel Hybrid Artificial Neural Network-Nonlinear Mixed Effect Model Modeling Approach for Population Data Analysis in Model-based Drug Development
16:50-17:10 William Denney N-dimensional Likelihood Profiling: An Efficient Alternative to Bootstrap
17:10-17:30 Gilbert Koch Modeling of delayed phenomena in PKPD by delay differential equations of lifespan type
  Social evening

Friday June 8
09:00-10:15 Lumping and identifiability chair: Leon Aarons
09:00-09:35 Aris Dokoumetzidis Tutorial: Lumping of compartments
09:35-09:55 Jin Jin Model-Based Meta-Analysis for the Efficacy and Safety of Paclitaxel in Cancer Patients
09:55-10:15 Yasunori Aoki A practical algorithm for practical parameter identifiability analysis
10:15-10:25 Preview of PAGE 2013
10:25-10:55 Coffee break
10:55-12:15 Variability models and optimal design chair: Marylore Chenel
10:55-11:15 Anne-Gaelle Dosne A strategy for residual error modeling incorporating both scedasticity of variance and distribution shape
11:15-11:35 Ron Keizer Extended NPDE diagnostics for the between-subject variability and residual error model
11:35-11:55 Camille Vong Handling Below Limit of Quantification Data in Optimal Trial Design
11:55-12:15 France Mentré Survey on the current use of optimal design approaches and the developments needed in adaptive optimal design for model based analysis performed amongst DDMoRe’s EFPIA members
12:15-12:25 Closing remarks
12:25-12:40 Audience input for the PAGE 2013 program