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2004
   Uppsala, Sweden

Adaptive Designs : Bayesian & Non-Bayesian Approaches

Andy Grieve

Pfizer Global R&D, Sandwich, UK

PDF of presentation

The recent past has seen a considerable increase in the use of flexible and adaptive designs. However adaption is not new.† In this tutorial I will discuss a taxonomy of clinical trial designs which will cover many of the adaptive designs which are available.† These will run from very simple up-and-down designs which have been used for more than 50 years, to very complex designs involving surrogate end-points and Bayesian decision making.
All of the designs will be illustrated with examples.



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