Adaptive Designs : Bayesian & Non-Bayesian Approaches
Pfizer Global R&D, Sandwich, UK
The recent past has seen a considerable increase in the use of flexible and adaptive designs. However adaption is not new. In this tutorial I will discuss a taxonomy of clinical trial designs which will cover many of the adaptive designs which are available. These will run from very simple up-and-down designs which have been used for more than 50 years, to very complex designs involving surrogate end-points and Bayesian decision making.
All of the designs will be illustrated with examples.