PsN and Xpose
Rikard Nordgren, Andrew C. Hooker, Kajsa Harling, Svetlana Freiberga and Mats O. Karlsson
Pharmacometrics group, Department of Pharmaceutical Biosciences, Uppsala University, Sweden
PsN is a toolbox for population PK/PD model building using NONMEM. It has broad functionality ranging from results extraction from output files to advanced computer-intensive statistical methods. Updates since PAGE 2016 include major extensions to simeval [1], a tool for simulation-evaluation diagnostics for outlier detection, updates to frem [2,3], a tool for full random effects modelling for covariate building, resmod [4], a new tool to evaluate different residual models, the addition of support for rmarkdown when using rplots greatly facilitating the automatic creation of reports, support for NONMEM 7.4 and the migration of the development and public webpages to github for simplified interaction with the community.
Xpose 4 is an open-source population PK/PD model building aid for NONMEM. Xpose attempts to facilitate the use of diagnostics in an efficient manner, providing a toolkit for dataset checkout, exploration and visualization, model diagnostics, candidate covariate identification and model comparison.
Xpose has customized functions for generating plots based on PsN output, and several of them can be automatically run by adding the -rplots option to the PsN command. This gives pdf documents with, for example, visual predictive checks as part of the PsN output, without the need to manually run any R script.
Both PsN and Xpose are freely available at https://uupharmacometrics.github.io/PsN/ and at http://xpose.sourceforge.net
Acknowledgments: This work was supported in part by the DDMoRe (www.ddmore.eu) and IDeAl (www.ideal.rwth-aachen.de) projects.
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[3] Yngman G, Nyberg J, Jonsson EN, Karlsson MO, Abstr PAGE 26 (2017).
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