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Lewis Sheiner


2018
Montreux, Switzerland



2017
Budapest, Hungary

2016
Lisboa, Portugal

2015
Hersonissos, Crete, Greece

2014
Alicante, Spain

2013
Glasgow, Scotland

2012
Venice, Italy

2011
Athens, Greece

2010
Berlin, Germany

2009
St. Petersburg, Russia

2008
Marseille, France

2007
KÝbenhavn, Denmark

2006
Brugge/Bruges, Belgium

2005
Pamplona, Spain

2004
Uppsala, Sweden

2003
Verona, Italy

2002
Paris, France

2001
Basel, Switzerland

2000
Salamanca, Spain

1999
Saintes, France

1998
Wuppertal, Germany

1997
Glasgow, Scotland

1996
Sandwich, UK

1995
Frankfurt, Germany

1994
Greenford, UK

1993
Paris, France

1992
Basel, Switzerland



Printable version

PAGE. Abstracts of the Annual Meeting of the Population Approach Group in Europe.
ISSN 1871-6032

Reference:
PAGE 25 (2016) Abstr 5916 [www.page-meeting.org/?abstract=5916]


PDF poster/presentation:
Click to open Click to open

Software Demonstration


S-01 Kajsa Harling PsN and Xpose

Kajsa Harling, Andrew C. Hooker, Rikard Nordgren and Mats O. Karlsson

Pharmacometrics group, Department of Pharmaceutical Biosciences, Uppsala University, Sweden

PsN is a toolbox for population PK/PD model building using NONMEM 6 and 7. It has broad functionality ranging from results extraction from output files to advanced computer-intensive statistical methods. Updates since PAGE 2015 include major extensions to sir, a tool for fast and robust assessment of parameter uncertainty with automatically generated visual diagnostics of convergence and parameter confidence intervals, simeval, a tool for simulation-evaluation diagnostics for outlier detection, and benchmark, a tool for simple comparisons of estimation results and approximate run times across combinations of NONMEM options, Fortran compiler and NONMEM versions.

Xpose 4 is an open-source population PK/PD model building aid for NONMEM. Xpose attempts to facilitate the use of diagnostics in an efficient manner, providing a toolkit for dataset checkout, exploration and visualization, model diagnostics, candidate covariate identification and model comparison.

Xpose has customized functions for generating plots based on PsN output, and several of them can be automatically run by adding the -rplots option to the PsN command. This gives pdf documents with, for example, visual predictive checks as part of the PsN output, without the need to manually run any R script.

Both PsN and Xpose are freely available at http://psn.sourceforge.net and at http://xpose.sourceforge.net

Acknowledgments: This work was supported in part by the DDMoRe (www.ddmore.eu) and IDeAl (www.ideal.rwth-aachen.de) projects.



References:
[1] Jonsson EN, Karlsson MO. Xpose--an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM. Computer Methods and Programs in Biomedicine. 58(1):51-64.
[2] Lindbom L, Ribbing J, Jonsson EN. Perl-speaks-NONMEM (PsN)--a Perl module for NONMEM related programming. Comput Methods Programs Biomed. 75(2):85-94.
[3] Lindbom L, Pihlgren P, Jonsson EN. PsN-Toolkit--a collection of computer intensive statistical methods for non-linear mixed effect modeling using NONMEM. Comput Methods Programs Biomed. 79(3):241-57.
[4] Keizer RJ, Karlsson MO, Hooker A. Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose. CPT Pharmacometrics Syst Pharmacol. (2013) 2, e50.
[5] Dosne AG, Bergstrand M, Karlsson MO. Application of Sampling Importance Resampling to estimate parameter uncertainty distributions. PAGE 22 (2013) Abstract 2907.
[6] Dosne AG, Bergstrand M, Karlsson MO. Determination of Appropriate Settings in the Assessment of Parameter Uncertainty Distributions using Sampling Importance Resampling (SIR). PAGE 24 (2015) Abstract 3546.
[7]  Largajolli A, Jönsson S, Karlsson MO. The OFVPPC: A simulation objective function based diagnostic. PAGE 23 (2014) Abstract 3208.