PsN and Xpose
Kajsa Harling, Andrew C. Hooker, Rikard Nordgren and Mats O. Karlsson
Pharmacometrics group, Department of Pharmaceutical Biosciences, Uppsala University, Sweden
PsN is a toolbox for population PK/PD model building using NONMEM 6 and 7. It has broad functionality ranging from results extraction from output files to advanced computer-intensive statistical methods. Updates since PAGE 2015 include major extensions to sir, a tool for fast and robust assessment of parameter uncertainty with automatically generated visual diagnostics of convergence and parameter confidence intervals, simeval, a tool for simulation-evaluation diagnostics for outlier detection, and benchmark, a tool for simple comparisons of estimation results and approximate run times across combinations of NONMEM options, Fortran compiler and NONMEM versions.
Xpose 4 is an open-source population PK/PD model building aid for NONMEM. Xpose attempts to facilitate the use of diagnostics in an efficient manner, providing a toolkit for dataset checkout, exploration and visualization, model diagnostics, candidate covariate identification and model comparison.
Xpose has customized functions for generating plots based on PsN output, and several of them can be automatically run by adding the -rplots option to the PsN command. This gives pdf documents with, for example, visual predictive checks as part of the PsN output, without the need to manually run any R script.
Acknowledgments: This work was supported in part by the DDMoRe (www.ddmore.eu) and IDeAl (www.ideal.rwth-aachen.de) projects.
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