# 2011

Athens, Greece

I-11 Paul BaverelA novel covariate search method intended for PKPD models with nonparametric parameter distributionsWednesday 10:15-11:45 |

I-13 Benoît BeckFrom the Experimental Model Settings to the Physical System for Interpretable Decision MakingWednesday 10:15-11:45 |

I-17 Julie BertrandMultiple SNP analysis with HyperLasso in Pharmacogenetic Studies using Nonlinear Mixed Effects ModelsWednesday 10:15-11:45 |

I-18 Bruno BiethUsing a Systems Biology Approach to Explore Clinical Diversity and Investigate Mechanism of Drug Action: Example of the RAAS System in HypertensionWednesday 10:15-11:45 |

I-19 Roberto BizzottoDrug Effects on Sleep Data from a 28-Day Clinical Study in Insomniac Patients: Covariate Analysis Using a Multinomial Mixed-Effect Markov-Chain ModelWednesday 10:15-11:45 |

I-20 Marcus BjörnssonPerformance of non-linear mixed effects models with and without taking informative dropout into accountWednesday 10:15-11:45 |

I-25 Massoud BoroujerdiA Negative feedback model for a mechanism based description of longitudinal observations: application for bone turnover biomarkers.Wednesday 10:15-11:45 |

I-26 Marion Bouillon-PichaultModeling Pain score in clinical trials using a joint survival-longitudinal mixed model with a Beta distribution in presence of missing values not occurring at random.Wednesday 10:15-11:45 |

I-31 Anne BrochotSpecifying Models with Time Dependent Pharmacokinetic Parameters in NONMEMWednesday 10:15-11:45 |

I-33 Vincent BuchheitEfficient quality review for modeling input datasetWednesday 10:15-11:45 |

I-42 Marylore ChenelBSA-adjusted dose? An old method to fight old biasWednesday 10:15-11:45 |

I-43 S. Y. Amy CheungStructural identifiability of parallel pharmacokinetic experiments as constrained systemsWednesday 10:15-11:45 |

I-52 Emmanuelle CometsA comparison of bootstrap approaches for estimating standard errors of parameters in linear mixed effects modelsWednesday 10:15-11:45 |

I-53 Carolyn CoulterUtilising prior literature population models to inform clinical practice - a dosing regimen for immediate N-acetyl cysteine treatment of paracetamol overdoseWednesday 10:15-11:45 |

I-55 Roosmarijn De CockMaturation of GFR in preterm and term neonates reflected by clearance of different antibioticsWednesday 10:15-11:45 |

I-58 Maud DelattrePharmacokinetics and stochastic differential equations : model and methodology.Wednesday 10:15-11:45 |

I-64 Aris DokoumetzidisNumerical solution of nonlinear fractional compartmental systemsWednesday 10:15-11:45 |

I-65 Aris DokoumetzidisMultiple dosing for linear fractional pharmacokinetic systemsWednesday 10:15-11:45 |

II-13 Axel FaciusModelling and Simulation based Techniques to support Trial Design and Submission of DaxasWednesday 14:55-16:10 |

II-19 Christina FriedrichComparison of Statistical and Physiological Modeling Methods Using Examples in Drug Discovery and DevelopmentWednesday 14:55-16:10 |

II-47 Vijay IvaturiSelection Bias in Pre-Specified Covariate ModelsWednesday 14:55-16:10 |

II-53 Åsa KraghComparison of methods for handling missing covariate dataWednesday 14:55-16:10 |

II-57 Takayuki KatsubeEvaluation of Stepwise Covariate Model Building Combined with Cross-ValidationWednesday 14:55-16:10 |

II-58 Ron KeizerThe bootstrap of Stepwise Covariate Modeling using linear approximationsWednesday 14:55-16:10 |

II-62 Akash KhandelwalInfluence of Correlated Covariates on Predictive Performance for Different ModelsWednesday 14:55-16:10 |

III-11 Natacha LenuzzaDevelopment of a PK library of parent drug/metabolite integrated modelsThursday 09:50-11:05 |

III-18 Eleonora MarosticaPopulation state-space modelling of patient responses in antidepressant studiesThursday 09:50-11:05 |

III-19 Hafedh MarouaniKinetic nomograms assist individualization of drug regimensThursday 09:50-11:05 |

III-23 Christophe MeillePK/PD Model of skin toxicity in animal reported as binary outcomeThursday 09:50-11:05 |

III-60 Klaas PrinsModeling urge urinary incontinence data acknowledging non-Poisson dispersion of counts within individual provides a major model fit improvement.Thursday 09:50-11:05 |

III-61 Klaas PrinsUse of a generalized poisson model to describe micturition frequency in patients with overactive bladder disease.Thursday 09:50-11:05 |

IV-01 Alberto RussuIntegration of response, tolerability and dropout in flexible-dose trials: a case study in depressionThursday 15:05-16:20 |

IV-14 Doerthe StellerExtension of Continuous-Time PK/PD Markov Models to Published Count DataThursday 15:05-16:20 |

IV-23 Nadia TerranovaA non parametric population approach for selecting biomarkers of a drug actionThursday 15:05-16:20 |

IV-25 Michel TodA meta-analysis regression model for quantitative prediction of the impact of polymorphism on drug exposureThursday 15:05-16:20 |

IV-29 Kuenhi TsaiEvaluating Bootstrap Methods in Nonlinear Mixed Effect Models (NMEM) Using a PK ModelThursday 15:05-16:20 |

IV-48 Thomas WendlModeling of renal failure, dialysis, inhalation and mechanical ventilation: Development of a whole-body physiologically-based pharmacokinetic (PBPK) model for ICU patients with and without renal failure receiving inhalatively administered Amikacin via a tracheal tube.Thursday 15:05-16:20 |