NONMEM® 7.3 and 7.4 and PDx-Pop® 5.2
Robert J Bauer
ICON Clinical Research LLC
Please stop by at our booth at PAGE 2016 to learn of the present release of NONMEM 7.3, our upcoming features in NONMEM 7.4, and our just released version of PDx-Pop 5.2.
ICON is committed to providing the most advanced analysis methods and tools for the pharmaceutical industry through continued enhancements to the NONMEM® software, the industry standard for population pharmacokinetic/pharmacodynamics analysis; ensuring pharmaceutical companies may continue to use this trusted analysis tool, incorporating classical as well as new analysis algorithms for present day pharmaceutical development. In addition, PDx-Pop™, a graphical interface working in concert with NONMEM®, integrates with existing tools and its own automated methods to expedite population modeling and analysis, providing optimal flexibility, increased efficiency and functionality.
NONMEM® – Continuous Enhancements:
NONMEM® has been relied on by the PK/PD modeling community for over 30 years, so ICON understands the importance of continuously improving this trusted tool for analysing Population Pharmacometric data. Statistical analysis with NONMEM helps sponsors determine appropriate dosing strategies for their products, and increases their understanding of drug mechanisms and interactions. With NONMEM’s new features, such as algorithms that improve the performance of Monte Carlo and classical estimation methods, the information needed for critical decision- making will be available faster and more efficiently.
The latest release of NONMEM is 7.3, incorporating the following enhancements:
- More efficient memory allocation for sizing problems, particularly for huge models with many parameters to be estimated.
- More mixed effects levels, with random effects across groups of individuals such as clinical site, may now be modeled. Sites themselves may be additionally grouped, such as by country, etc.
- Algorithms to assess optimal settings for Monte Carlo estimation methods.
- Algorithms to aid in global optimization of classical estimation methods.
- Expanded language facilities for the control stream file, such as handling repetitive code, symbolic references to indexed parameters, extending code across lines, up to 67000 characters.
- Built-in bootstrap algorithms with stratification.
- Enhanced non-parametric analysis methods.
We are presently developing NONMEM 7.4. Some of the new features are:
- Parallelization extended to additional tasks
- Improved Speed for FOCE/ITS Analyses
- Improvements in IMP, SAEM and BAYES Analysis
- Additional Table Output Control: Specific control of which records to be outputted
- Further Symbolic Code enhancement of control stream code
- Read MSF files Generated from Earlier Versions of NONMEM
- Preconditioning and SIR sampling of Covaraince of extimates assessment
PDx-Pop® – Visual Companion for NONMEM, Expediting Population Analysis:
Just released is Pdx-Pop 5.2, fully compatible with NONMEM 7.3:
- Control Stream, PK and User (including ODE) Modeling and Advanced Methods Wizards to assist in model development and MU referencing
- Multi-Processor Capability for Batched Runs of multiple control stream files
- Extended summary output of including estimated population parameters and relative standard error, and goodness of fit statistics
- Automated R/S-Plus plots of diagnostic plots, estimated parameters (qqplots, histograms) and etas (pairs plots, histograms), Bayesian parameter sampling history plots
- Access Custom User-written R/S-Plus scripts from PDx-Pop
- Automated classical, standardized, and prediction corrected Visual Predictive Check.
- Easy Multi-processor distribution of bootstrap runs, using NONMEM 7.3’s built-in bootstrap algorithm.
