PAGE. Abstracts of the Annual Meeting of the Population Approach Group in Europe.
PAGE 24 (2015) Abstr 3622 [www.page-meeting.org/?abstract=3622]
Click to open
Sebastian G. Wicha (1), Martin G. Kees (1,2), Alexander Solms (3), Iris K. Minichmayr (1), Alexander Kratzer (4), Charlotte Kloft (1)
(1) Dept. of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Germany, (2) Dept. of Anaesthesiology and Intensive Care, Charité Universitaetsmedizin Berlin - Campus Benjamin Franklin, Berlin, Germany, (3) Institute of Mathematics, University of Potsdam, Germany, (4) Hospital Pharmacy, University Hospital Regensburg, Germany
Background: Pharmacometric models have evolved as useful tools to quantify and explain pharmacokinetic (PK) variability between patients and to explore its resulting pharmacodynamic (PD) consequences e.g. on probabilities of target attainment (PTA) of anti-infectives. The application of pharmacometric PK/PD models in clinical practice is yet limited, as available software is either difficult to use or lacks functionality. Hence, we aimed to develop ‘TDMx’ (www.tdmx.eu), an easy-to-use, but powerful modular software tool for bedside dosing decisions, making use of state-of-the-art pharmacometric techniques such as (i) probability of target attainment analysis without requiring drug measurements, (ii) Bayesian PK estimation and definite PK/PD target attainment analysis if drug measurements are available and (iii) (adaptive) optimal design to sample at the most informative time points. As a starting point, population PK models for the anti-infectives gentamicin, amikacin, meropenem and piperacillin have been implemented.
Conclusion: With ‘TDMx’, we provide a user-friendly and powerful web-application, making use of state-of-the art pharmacometric techniques to support bedside dosing decision-making. In comparison to other currently available tools, ‘TDMx’ offers broader functionality and can entirely be used in a web browser.