Thursday 16 October, 2025
Gliclazide is a sulphonylurea which possesses hypoglycaemic activity and acts against both platelet adhesiveness and aggregation. Owing to its double…
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Population Pharmacokinetics: Effect Of Polytherapy On Valproic Acid Clearance
Thursday 16 October, 2025
The aim of this study was to investigate the influence of coadministration of another antiepileptic drug (carbamazepine-CBZ-, phenytoin-PHT-, phenobarbital-PB-, lamotrigine-LAM-,…
Read moreCovariate Model Building In Population Analysis Using A Bootstrap Resampling Procedure
Thursday 16 October, 2025
One of the main benefits of non-linear mixed effects modelling over traditional methods to obtain estimates of population parameters is…
Read morePopulation Pharmacokinetic Analysis Of Eltanolone
Thursday 16 October, 2025
Eltanolone, 3a-hydroxy-5b-pregnan-20-one, is a naturally occurring metabolite of progesterone, which has been under development for use in humans for the…
Read moreAn Algorithm for the Estimation of Optimal Sampling Times in Pharmacokinetics by the ED, EID and API Criteria
Thursday 16 October, 2025
The most common approach to optimize the sampling schedule in parameter estimation experiments is the D-optimaly criterion, which consists in…
Read moreA Population Pharmacokinetic Study of Isepamicin in ICU Patients
Thursday 16 October, 2025
The pharmacokinetics (PK) of isepamicin, a new aminoglycoside, were studied in 85 intensive care unit (ICU) patients and compared to…
Read morePopulation Pharmacokinetics of Intravenous Melphalan: NONMEM and MP2 Analysis
Thursday 16 October, 2025
Introduction: The alkylating agent melphalan has been used for 30 years in a variety of malignant tumors. Previous pharmacokinetic studies…
Read moreMP2 (MicroPharm Population): A Windows Application for Population Pharmacokinetics
Thursday 16 October, 2025
This project is developed for population pharmacokinetic modeling of experimental data. The program is written in Pascal language based on…
Read moreA Population Approach Enables the Characterisation of Saturable Protein Binding for Ropivacaine
Thursday 16 October, 2025
Ropivacaine is a new amide-type local anaesthetic drug similar to bupivacaine. A study has been carried to out to investigate…
Read moreSoftware product POPKAN; Population pharmacokinetic modelling and analysis
Thursday 16 October, 2025
POPKAN is a userfriendly PC-based software system enabling pharmacokinetic researchers to apply the population approach to kinetic and dynamic data…
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