J Wakefield, G Strehlau
Mathematical Applications, CIBA-GEIGY AG, Basel, Switzerland
- POPKAN
- is a userfriendly PC-based software system enabling pharmacokinetic researchers to apply the population approach to kinetic and dynamic data profiles.
- POPKAN
- is an expert system. It offers by a point and click-strategy a full Bayesian solution of complex hierarchical models. POPKAN’s computational engine contains the complex Markov Chain Monte Carlo Sampling methodology – a statistical method at frontier of science level – but the user does not need to understand this methodology and does not need to become a statistical expert.
- POPKAN
- presents the analysis results in graphical forms and numerical summeries. All results can be stored and later be reused and/or integrated in SAS or another reporting system.
- POPKAN
- offers robust analysis methodology and a variety of graphical diagnostics for model validation and outlier detection.
- POPKAN
- provides pharmacokinetic and pharmacodynamic prediction for individuals and optimal dosing regimens.
- POPKAN
- offers flexible specification features in form of
- Data:
- either SAS-files or ASCII.
- Application mode:
- single or repeated application schemes for IV, INFUSIONS and PO mode.
- Kinetic models:
- one and two compartment models.
- Dynamic models:
- linear regression and E-max-models.
Reference: PAGE 4 () Abstr 646 [www.page-meeting.org/?abstract=646]
Poster: poster