Thursday 16 October, 2025
PDF of poster The paclitaxel disposition is nonlinear and hepatic metabolism and biliary excretion have important roles. The influence of…
Read moreposter
Tegafur and 5-Fluorouracil pelvic tissues concentrations in rectal cancer patients treated with preoperative chemoradiation. The processed sample stability investigation and their impact in the reability of data
Thursday 16 October, 2025
PDF of poster Tegafur (Ftorafur), 1-(tetrahydro-2-furanyl)-5-fluorouracil, a oral prodrug of 5-fluorouracil (known radiopotentiating agent in preclinical models), has an efficacy…
Read morePharmacokinetics and bioavailability of new ciprofloxacin derivative (CNV 97101) in rat: repercussion of precipitation in stomach.
Thursday 16 October, 2025
PDF of poster Purpose: A method of deconvolution by curve fitting is presented and applied to the estimation of oral…
Read moreImplementation of variability in a physiologically-based pharmacokinetic approach for simulating the first-in-animal study.
Thursday 16 October, 2025
PDF of poster Objectives: The objective of this study was to evaluate the influence of different sources of variability in…
Read morePatients’ Non-compliance with Drug Administration Times and Optimal Population Design in Pharmacokinetics.
Thursday 16 October, 2025
Objectives: Optimal designs in population pharmacokinetics (PK) usually assume that drug administration times are fixed in the trial. However, the…
Read morePopulation pharmacokinetics of high-dose methotrexate in osteosarcoma pediatric patients.
Thursday 16 October, 2025
PDF of poster Introduction and Objectives: High-dose methotrexate (HD_MTX) is an efficient component of therapy in children with osteosarcoma. The…
Read moreAnalyzing Multi-response Data Using Forcing Functions: illustrated in pharmacokinetic physiological flow modeling
Thursday 16 October, 2025
PDF of poster Objectives: To analyze multi-response data, a multivariate output model can be fit to all the response components…
Read morePopulation Pharmacokinetics of Rituximab in RA (Rheumatoid Arthritis) Patients: Combining two phase II studies
Thursday 16 October, 2025
PDF of poster Objectives: Rituximab (RTX; a CD20+-targeted therapeutic antibody) is currently licensed to treat non-Hodgkin’s lymphoma using a body…
Read moreThe influence of an increase in plasma protein binding on the pharmacokinetics and pharmacodynamics of S(-)-Propranolol
Thursday 16 October, 2025
PDF of poster Objectives: Protein binding can have a major impact on a drug’s pharmacokinetics (PK) and pharmacodynamics (PD). At…
Read moreUse of an indirect effect model to describe the LDL Cholesterol lowering process by statins
Thursday 16 October, 2025
PDF of poster Introduction: Statins (HMG-COA redustase inhibitors) are the most commonly prescribed agents for the treatment of hypercholesterolemia. This…
Read more