Thursday 16 October, 2025
The aim of the study was to determine the relationship between theophylline concentration and its effect in reducing incidences of…
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Pharmacokinetics of amikacin in intensive care unit patients: population analysis.
Thursday 16 October, 2025
The aim of the present study was to analyse the amikacin pharmacokinetic behaviour in intensive care unit (ICU) patients by…
Read morePopulation Pharmacokinetics Of Gentamicin In Oncology Patients
Thursday 16 October, 2025
The population pharmacokinetics of gentamicin were investigated in patients with cancer using NONMEM. Data were collected prospectively from 210 patients…
Read moreOn estimating half-life using population pharmacokinetics
Thursday 16 October, 2025
The POP-PK literature is remarkably silent in providing guidance on estimating t1/2 and its variance when, as is usual, the…
Read moreAn Alternative Definition Of Individual Bioequivalence
Thursday 16 October, 2025
Two formulations of a drug are declared bioequivalent if their bioavailabilities are similar. Under bioequivalence the two formulations are considered…
Read morePharmacokinetic-Dynamic Modelling Of Neutropenic Effect Of Melphalan Using NONMEM Associated With A Cubic Spline Function
Thursday 16 October, 2025
Aim of the study: The marked inter- and intrapatient variability of the pharmacokinetics of a number of antineoplastic agents is…
Read moreA Mixed-Effects Modelling Approach To The Analysis Of Verapamil-GITS Blood Pressure Data
Thursday 16 October, 2025
A longitudinal clinical trial was undertaken in which verapamil was administered orally daily at 10 pm to patients for a…
Read moreContribution Of Nonparametric Population Pharmacokinetic Software To The Determination Of Diurnal Variations Of Drug Pharmacokinetic Parameters
Thursday 16 October, 2025
Drug disposition in man can particularly be affected by biological rhythms, such as diurnal variations observed in excretion rate by…
Read morePopulation Pharmacokinetic Analysis Of Mizolastine In Healthy Young Volunteers And Allergic Patients Using NONMEM
Thursday 16 October, 2025
The pharmacokinetic profile of mizolastine, a new antihistamine agent, was assessed firstly in 18 healthy young volunteers after a single…
Read morePharmacokinetic Population Analysis Of SDZ ENA 713 And Its Metabolite In Patients; Relationships With Efficacy, Safety And Tolerability
Thursday 16 October, 2025
A pharmacokinetic/pharmacodynamic (PK/PD) population approach was implemented in a phase II efficacy and tolerability trial of SDZ ENA 713, a…
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