Thursday 16 October, 2025
Introduction For a successful therapy with beta-lactam antibiotics, it is mandatory to maintain the drug plasma concentrations above the MIC…
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Population Pharmacokinetics Analysis of Mizolastine: Estimation with NPML and Validation
Thursday 16 October, 2025
A population analysis of the kinetics of a new antihistamine, mizolastine, and the validation of this study were performed using…
Read moreHigh Variability Compounds – High Risk for Developers?
Thursday 16 October, 2025
During the drug development process compounds that exhibit large (unexplained) interindividual differences in plasma concentrations may fail to be advanced…
Read moreModeling Interoccasion Variability in Toxicokinetics and Toxicodynamics
Thursday 16 October, 2025
The presence of interoccasion variability (IOV) in toxicokinetic parameters was investigated using the approach of Karlsson and Sheiner (1). Data…
Read moreA Population Approach to Predicting Post-Treatment Levels of Epirubicin in Patients with Advanced Breast Cancer
Thursday 16 October, 2025
Introduction In clinical practice, the dosage used in cytotoxic drug therapy is usually empirical, based on body surface area, and…
Read morePerformance Evaluation of Three Softwares for Bayesian Predictions of Teicoplanin Pharmacokinetic Parameters: APIS MICROPHARM, PKS Abbott
Thursday 16 October, 2025
Teicoplanin is a glycopeptide antibiotic related to vancomycin and is active against Gram-positive aerobic and anaerobic bacteria including methicillin-resistant staphylococci….
Read moreInfluence of Apomorphine on the PK/PD-Relationship of Levodopa: Two-Step versus NONMEM Analysis
Thursday 16 October, 2025
Apomorphine (AM) is an agonist of dopaminergic receptors in the striatum. We investigated the influence of AM given in a…
Read moreLack of Relationship between Systemic Exposure for the Component Drugs of the FEC Regimen in Breast Cancer Patients
Thursday 16 October, 2025
Purpose The aim of this study was to investigate the covariance between the pharmacokinetics of the three components of the…
Read moreCarbamazepine Population Pharmacokinetics in Children
Thursday 16 October, 2025
The objective of this study was to describe the pharmacokinetics of carbamazepine (CBZ) in pediatric patients who received CBZ (Tegretol)…
Read moreEstimation of Kinetic/Dynamic Curves With Insufficient Information for Each Individual Using Non-Linear Mixed Effect Modelling
Thursday 16 October, 2025
When trying to fit model equations to experimental data, the situation may arise that individual subjects do not provide sufficient…
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