Thursday 16 October, 2025
Background: Cyclophosphamide (CY) is an alkylating agent frequently used in the treatment of malignancy and in preparative regimens for hematopoietic…
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Reducing PBPK Models Using Global Sensitivity Analysis and Benefit/Cost Criterion
Thursday 16 October, 2025
Currently, PBPK models are used mainly in preclinical drug development to predict human PK extrapolated from animal studies. Due to…
Read moreRetrospective Population Pharmacokinetic Analysis of Levetiracetam in Westerner and Japanese Adults
Thursday 16 October, 2025
Objective: The aim of the analysis was to identify demographic and/or physiologic determinants of levetiracetam disposition in healthy subjects and…
Read morePopulation pharmacokinetic modelling of Emfilermin in healthy postmenopausal women and in women undergoing Embryo Tranfer (ET)
Thursday 16 October, 2025
Background: Current evidence suggests that endogenous leukaemia inhibitory factor (LIF) – a heavily glycosylated cytokine plays a physiological role in embryo…
Read moreModelling of drug absorption as a transport-limited process
Thursday 16 October, 2025
Objectives: To explore the properties of an oral absorption model that considers the transport limitation between the sites of administration…
Read moreGrey-box Modelling of Insulin Clamp Study
Thursday 16 October, 2025
Grey-box PK/PD Modelling of insulin is presented as a promising way of modelling the dynamics of the insulin/glucose system and…
Read moreBayesian Networks used in PK/PD modelling
Thursday 16 October, 2025
A Bayesian network is a graphical model that encodes the joint probability distribution of stochastic variables, which in our case…
Read moreA Bayesian Approach to Bergman’s Minimal Model
Thursday 16 October, 2025
The classical minimal model of glucose disappearance (Bergman et al., 1979) was proposed as a powerful modelling approach to estimating…
Read moreDose-response analysis of levetiracetam add-on treatment in patients with partial epilepsy
Thursday 16 October, 2025
Objectives: The aim of this population analysis was to describe the individual change in seizure frequency from baseline after treatment…
Read morePharmacokinetic analysis of paclitaxel administered per os in Swiss mice after a pre-treatment with recombinant interleukin-2 (rIL2).
Thursday 16 October, 2025
Objectives: Paclitaxel is a potent anticancer drug with proven activity against a broad range of human malignancies, including ovarian and…
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