Thursday 16 October, 2025
Ayahuasca is a South American psychotropic plant tea used since pre- Columbian times in the Upper Amazon and Orinoco River…
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Population pharmacokinetic/pharmacodynamic modeling of the possible tolerance development after a single oral dose of different BZD-GABAa agonists.
Thursday 16 October, 2025
Introduction: A commonly described situation for benzodiazepines (BZD) is the tolerance development after chronic administration. However, although many investigators have…
Read moreMetrics based on objective function for external validation of a population pharmacokinetic model
Thursday 16 October, 2025
PDF of poster Objectives: An important step in population pharmacokinetic model building is to evaluate the model’s adequacy. We propose…
Read moreComparison of several prediction errors on concentrations for model evaluation
Thursday 16 October, 2025
PDF of poster objectives: The aim of this study is to compare criteria for the evaluation of a population pharmacokinetic…
Read morePopulation pharmacokinetic analysis of indinavir in HIV-patients treated with a stable antiretroviral therapy
Thursday 16 October, 2025
Objectives: The objectives of this study were to build a population pharmacokinetic model that describes plasma concentrations of indinavir in…
Read moreA pooled population pharmacokinetic analysis of tesaglitazar in patients with type 2 diabetes or with manifestations of insulin resistance
Thursday 16 October, 2025
PDF of poster PDF of poster Objectives: Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist under clinical development…
Read morePharmacokinetic and pharmacodynamic modelling of the dual PPAR α/γ agonist tesaglitazar in patients with manifestations of insulin resistance
Thursday 16 October, 2025
Objective: Tesaglitazar is a novel, dual peroxisome proliferator-activated receptor α/γ agonist under clinical development for the treatment of glucose and…
Read moreA disease model for the regulation of the glucose-insulin system
Thursday 16 October, 2025
PDF of poster Objectives: The aim of this project was to develop a mechanistic model to describe the glucose and…
Read morePsN Toolkit, a collection of computer intensive methods for population PK/PD
Thursday 16 October, 2025
Objectives: Many computer intensive methods useful in model building and model validation have been described in the literature [1, 2]….
Read moreSymmetry and coverage of confidence intervals for a population PK model.
Thursday 16 October, 2025
Standard error estimates give an indication of the quality of model parameter estimates and are useful tools in hypothesis testing….
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