Thursday 16 October, 2025
Objectives: TLL-018 is a novel selective Janus Kinase 1 / Tyrosine Kinase 2 inhibitor which is being developed for the treatment…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
Prediction of pulmonary exposure based on plasma pharmacokinetics: A comparison of different model-based approaches.
Thursday 16 October, 2025
Introduction: Different model-based approaches were applied to characterize the pharmacokinetics (PK) of orally inhaled drugs, differing prominently in the structural…
Read morePhysiologically based pharmacokinetic modeling of Herceptin and human pharmacokinetic prediction
Thursday 16 October, 2025
Objectives: The PBPK approach is known to be superior to traditional allometric approach when it comes to predictability of human…
Read moreApplication of virtual clinical studies to predict the effect of inter-individual differences on the drug/metabolites exposures in the blood and target organs leading to different pharmacological and toxicological effect
Thursday 16 October, 2025
Objectives: This study shows the potential of virtual clinical study (VCS) to predict the effect of inter-individual differences on drug…
Read morePrediction of PD-L1 receptor occupancy in the tumor with PBPK/RO model of PD-L1 inhibitors
Thursday 16 October, 2025
Objectives: Measurements of receptor occupancy (RO) are believed to provide the necessary information on the pharmacodynamics of immune checkpoint inhibitors….
Read morePhysiologically based pharmacokinetic modeling of anti-PD-1 therapeutic antibodies
Thursday 16 October, 2025
Introduction: Monoclonal antibodies (mAbs) are engineered immunoglobulins that have been used for several decades as therapeutic agents in immuno-oncology. Their…
Read moreCombining physiologically-based-pharmacokinetic modelling and a Bayesian method for prediction of ivabradine oral absorption and drug-drug interactions
Thursday 16 October, 2025
Introduction: Ivabradine (If currents inhibitor) is indicated in stable chronic angina and heart failure. Ivabradine and its main metabolite (S18982)…
Read moreReduced physiologically-based pharmacokinetic model of dabigatran etexilate-dabigatran and its application for prediction of intestinal P-gp-mediated drug-drug interactions
Thursday 16 October, 2025
Background: New recommendations from regulatory authorities have suggested dabigatran etexilate (DABE) as a clinical probe for intestinal P-gp-mediated drug-drug interaction…
Read moreA global sensitivity analysis of the Rodgers and Rowland equations predicting drug distribution in PBPK models
Thursday 16 October, 2025
Objectives: Physiologically-based pharmacokinetic (PBPK) models allow prediction of a drug’s pharmacokinetics (PK) by separating drug and system’s properties allowing their…
Read moreA physiologically-based pharmacokinetic modeling approach to assess the impact of chronic kidney disease
Thursday 16 October, 2025
Objectives: Chronic kidney disease (CKD) is a general term for various irreversible disorders of kidney structure or kidney function. It has…
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