Thursday 16 October, 2025
Objectives: Pneumonia stands as a significant contributor to global infection-related mortality. Primarily bacterial in origin, pneumonia necessitates antibiotic treatment as…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
Predicting in vivo disposition of OATP substrates from in vitro kinetics using mechanistic PBPK modelling
Thursday 16 October, 2025
Objectives: In vitro systems are widely used in drug discovery to predict in vivo properties such as drug clearance, reducing…
Read moreEvaluating Drug Interactions Between Ritonavir and Hydrocodone: Implications From Physiologically Based Pharmacokinetic Simulation
Thursday 16 October, 2025
Introduction: Ritonavir is a protease inhibitor (PI) that is frequently used as a “booster” to increase the pharmacokinetic exposure to co-administered PIs[1]. Ritonavir as…
Read morePBPK modelling based estimation of safe, and effective Molnupiravir doses for pediatric subpopulations against SARS-CoV-2
Thursday 16 October, 2025
Introduction: Although the end of COVID-19 pandemic has been declared, SARS-CoV-2 infection cases are still being reported worldwide [1]. During…
Read moreWB-PBPK-PD Modeling for Pharmacokinetics and Pharmacodynamics of GalNAc-Conjugated siRNAs
Thursday 16 October, 2025
Objectives: N-Acetyl-galactosamine small interfering RNAs (GalNAc-siRNA) are an emerging class of drugs that have revolutionized RNA interfering drug therapy due…
Read moreReliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?
Thursday 16 October, 2025
Introduction: Drug pharmacokinetic (PK) profiles observed in the blood stream are not always informative about the PK within the central…
Read moreModelling and simulation of the effect of a permeability enhancer on the absorption of a poorly permeable compound
Thursday 16 October, 2025
Introduction: Compound A is highly soluble at physiological pH, highly bound to proteins (%PPB >99.9%) and has poor permeability (Caco-2…
Read moreRelative impact of CYP2D6 phenotype, physiological changes and hepatic extraction ratio on drug exposure during pregnancy
Thursday 16 October, 2025
Title: Relative impact of CYP2D6 phenotype, physiological changes and hepatic extraction ratio on drug exposure during pregnancy Author: Karen Rowland Yeo1,…
Read moreA Minimal PBPK Model to Predict Biodistribution of Silica Nanoparticles in Mice
Thursday 16 October, 2025
Introduction: Due to their superior drug loading capacity, mechanical stability, and stimuli-responsive release profile for controlled drug delivery, silica nanoparticles…
Read moreSmall molecule drug absorption in inflammatory bowel disease and current implementation in PBPK models.
Thursday 16 October, 2025
Introduction: Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the intestinal mucosa, with predominant localization in the colon…
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