Thursday 16 October, 2025
Introduction: Voriconazole (VRC), a broad-spectrum antifungal, exhibits nonlinear pharmacokinetics (PK), with complex metabolism and large inter- and intraindividual variability. It…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
Unravelling the complex inhibition network of voriconazole and its metabolites using a middle-out PBPK approach
Thursday 16 October, 2025
Introduction: The broad-spectrum antifungal voriconazole (VRC) exhibits large inter- and intraindividual PK and PD variability, nonlinear PK and complex metabolism….
Read morePhysiologically-based pharmacokinetic (PBPK) modelling to explore the pharmacokinetics (PK) and drug-drug interactions (DDI) potential of midazolam and 1-hydroxymidazolam: the hypothesis of lysosomal trapping
Thursday 16 October, 2025
Introduction: PBPK modelling is a powerful tool to quantitatively explore and predict PK of drugs and the magnitude of DDIs….
Read moreA minimal PBPK model for plasma and cerebrospinal fluid pharmacokinetics of trastuzumab in patients with leptomeningeal carcinomatosis
Thursday 16 October, 2025
Objectives: Trastuzumab, an anti-HER2 monoclonal antibody (mAb), is used as standard treatment in HER2-positive breast cancer patients at the recommended dose…
Read moreMathematical modeling of gastric emptying: a joint model for losartan and its active metabolite EXP-3174
Thursday 16 October, 2025
Objectives: Develop a joint pharmacokinetic model, describing the kinetics of losartan (LOS) and its active metabolite (EXP-3174) that seem to…
Read morePrediction of human pharmacokinetics of subcutaneously administered insulin formulations
Thursday 16 October, 2025
Introduction: In 2035, one out of ten people in the global population is supposed to suffer diabetes [1]. Patients with…
Read morePBPK model-guided assessment of a liver function test
Thursday 16 October, 2025
Objectives: The diagnosis, as well as the prediction, of idiosyncratic adverse drug reactions (ADR) is challenging. Idiosyncratic ADRs are manifold,…
Read moreEvaluation of Prediction Performance of In Silico PBPK models of oral drug absorption
Thursday 16 October, 2025
Introduction: Oral drug absorption is a complex process depending on many factors including the physiochemical properties of the drug, characteristics…
Read moreDeveloping a physiology-based model of bile acid metabolism in men
Thursday 16 October, 2025
Objectives: Drug-induced liver injuries (DILI) are a frequent reason for safety-related project closure of pharmaceutical development programs as their mechanisms…
Read moreAssessing the cholestatic potential of drugs using a physiology-based model of the bile acid metabolism
Thursday 16 October, 2025
Objectives: Cholestasis is a major clinical manifestation of drug induced liver injuries (DILI) characterized by an impaired bile flow. In…
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