Thursday 16 October, 2025
Objectives: Systemic inflammation is known to impact drugs pharmacokinetics (PK) by different ways. In vitro tests have shown that exposure…
Read morePoster: Drug/Disease Modelling - Absorption & PBPK
Physiologically-based pharmacokinetic model to predict lung distribution of anti-infective agents
Thursday 16 October, 2025
Introduction: Bacterial respiratory tract infections (RTIs) are associated with high mortality and are the leading cause of infection-related death worldwide[1]….
Read morePhysiologically based pharmacokinetic modeling – application for renal and hepatic impairment
Thursday 16 October, 2025
Objectives: Hepatic and renal impairment can have an impact on pharmacokinetics in patients compared to individuals with normal hepatic or…
Read moreA PBPK approach for simulating the effect of liver cirrhosis on drug PK
Thursday 16 October, 2025
Objectives: Liver cirrhosis is a progressive disease which is associated with severe morphological and physiological changes. Those alterations are known…
Read morePBPK modelling of drug-drug interactions driven by moderate CYP3A inducers
Thursday 16 October, 2025
Objectives: In the field of in vitro –to-in vivo (IVIVE) translation of CYP3A induction, there is increasing understanding of how…
Read moreA Population based PBPK Modelling for the Prediction of Bile Salts Disposition within GI Luminal Fluids – Towards a Mechanistic Bile Salts Model
Thursday 16 October, 2025
Objectives: Bile salts (BS) play a crucial role in the solubilisation and the absorption of lipophilic and poorly soluble drug…
Read moreA PBPK model for the study of Azathioprine pharmacokinetics in rats and prediction in humans
Thursday 16 October, 2025
Objectives: The aim of this work was to develop a mechanistic model for the description of the pharmacokinetics of the drug…
Read moreBayesian Whole Body Population Physiologically Based Pharmacokinetic Approach for Characterization of Interindividual Variability of Diazepam
Thursday 16 October, 2025
Objectives: To develop a Bayesian population approach for an existing whole-body physiologically based pharmacokinetic (WBPBPK) model of Diazepam in order…
Read morePharmacokinetic modeling of Donepezil after transdermal administration in rat
Thursday 16 October, 2025
Purpose: Donepezil (DPZ) is a widely used for treatment of Alzheimer’s disease. But, most of patients were suffered from gastrointestinal symptoms…
Read moreA Mechanistic Pharmacokinetic Approach to the Development of Predictive Models in HIV-malaria co-infection.
Thursday 16 October, 2025
Objectives: To develop a physiologically-based pharmacokinetic (PBPK) model describing PK relationships between efavirenz and antimalarial. Methods: In the current project, a stepwise…
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