Thursday 16 October, 2025
Background: Cilomilast (ArifloÒ ) is a potent and selective PDE 4 inhibitor currently under development for the oral treatment of…
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Cilomilast (Ariflo
Comparison of NONMEM with the Two-Stage approach for obtaining population means of the pharmacokinetic parameters of fluoxetine
Thursday 16 October, 2025
Objectives: NONMEM has been validated primarily using simulated datasets and there are relatively few studies comparing the two-stage and population…
Read moreCan clinically useful population PK models for carbamazepine in pediatric epilepsy patients be developed based on routine therapeutic drug monitoring (TDM) data?
Thursday 16 October, 2025
PDF of poster Objectives: Population pharmacokinetics (PPK) models for implementation in Bayesian adaptive control strategies have been developed for several…
Read moreBayesian Estimation of Epirubicin Clearance by Limited Sampling
Thursday 16 October, 2025
Introduction: Epirubicin is a cytotoxic anthracycline that is active against a wide range of tumours, including early or advanced breast…
Read moreBioavailability of gabapentin assessed by cumulative urine sampling compared with a model for the saturated absorption of gabapentin.
Thursday 16 October, 2025
PDF of poster Introduction: Gabapentin has a demonstrated analgesic effect in patients with chronic neuropathic pain states 1 and is…
Read morePopulation pharmacokinetic analysis of the new oral thrombin inhibitor dabigatran etexilate (BIBR1048) in patients undergoing primary elective total hip replacement surgery.
Thursday 16 October, 2025
Introduction: Dabigatran etexilate (BIBR 1048) is an orally available double prodrug of the active principle dabigatran (BIBR 953 ZW), which…
Read morePopulation pharmacodynamic analysis of dabigatran, the active form of the new oral direct thrombin inhibitor dabigatran etexilate (BIBR 1048), on the prolongation of aPTT and ECT in orthopaedic patients.
Thursday 16 October, 2025
Introduction: The oral direct thrombin inhibitor prodrug dabigatran etexilate is under development for the prevention of deep vein thrombosis in…
Read moreModelling of the Hamilton Depression Rating Scale in Unipolar Depression Trials
Thursday 16 October, 2025
PDF of poster Objectives: Depression trials are known to show large placebo response, which makes it very difficult to separate…
Read moreRandomized exposure-controlled trials; impact of randomization and analysis strategies – from a toxicity perspective
Thursday 16 October, 2025
PDF of poster Objectives: It has previously been shown[1] that the most beneficial parallel group trial design and analysis strategy…
Read moreRandomized dose ranging trials; assessment of statistical power for various design and analysis strategies
Thursday 16 October, 2025
Background: Historically the most used clinical trial design to describe the effectiveness of a drug is the randomized dose-controlled clinical…
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