Thursday 16 October, 2025
PDF of poster Introduction & Objective Ordered categorical data are commonly used to describe subjectively scored symptoms and side effects…
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An integrated model for data from a microdialysis experiment
Thursday 16 October, 2025
Background: Microdialysis measures the unbound concentration of a drug in a specific tissue. The microdialysis probe is perfused with a…
Read morePopulation approaches for quantitative PET imaging
Thursday 16 October, 2025
Objectives: Quantification of PET images requires the adoption of a model to measure physiological parameters. Usually, parameter estimation is performed,…
Read morePopulation Pharmacokinetic Analysis of Trastuzumab (Herceptin) following Long-Term Administration Using Different Regimens.
Thursday 16 October, 2025
PDF of poster Objective: To investigate trastuzumab pharmacokinetics and to assess the effect of covariates after long term trastuzumab administration…
Read morePharmacokinetics of Daunorubicin and its metabolite Daunorubicinol in the absence and presence of a potent P-gp inhibitor, Zosuquidar.3HCl (LY335979).
Thursday 16 October, 2025
Objectives: Clinical investigations have shown that P-glycoprotein inhibitors dramatically decrease the systemic clearance of co-administered oncolytics. The potential impact of…
Read moreComparison of alternative models for the analysis of drug disposition profiles showing enterohepatic circulation using a population approach
Thursday 16 October, 2025
Background & Objective: Enterohepatic recycling (ER) is associated with multiple peaks in concentration-time profile. Therefore a model analysis is always…
Read morePopulation pharmacokinetics of paroxetine in the pediatric population
Thursday 16 October, 2025
Aims: The aim of this work was to develop a population pharmacokinetic model for Paroxetine in pediatric patients and to…
Read moreImpact of slow receptor binding kinetics and change in Cerebral Blood Flow in receptor occupancy estimation with PET experiments. A simulation study
Thursday 16 October, 2025
Background: 11C is the most used labelling ligand despite its short half life (20 min). As a consequence no more…
Read moreModelling of the tolerance, rebound and carry-over phenomena observed in clomethiazole-induced hypothermic effects in rats.
Thursday 16 October, 2025
Objectives: Clomethiazole (CMZ) enhances g-aminobutyric acid (GABAA) receptor activity and is used as a sedative, hypnotic and anticonvulsant drug. In…
Read moreModeling of drug- and system-related changes in body temperature: application to drug-induced hypothermia, long-lasting tolerance development and diurnal variation in body temperature
Thursday 16 October, 2025
PDF of poster Objectives: Clomethiazole (CMZ), an agonist for the GABA(A) receptor, has been shown to induce rapid and long…
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