Thursday 16 October, 2025
PDF of poster Introduction: We developed a minimal pharmacokinetic-pharmacodynamic model describing the effect of an anticancer agent to the tumor…
Read moreposter
Application of population approaches in pharmaco-toxicological studies
Thursday 16 October, 2025
Objectives:In a typical toxicokinetic program, the pharmacokinetic information is obtained from different studies characterized by a limited number of observations…
Read moreA Bayesian approach to non-parametric AUC estimation in population studies
Thursday 16 October, 2025
Objectives: In cases in which frequent and/or fixed individual samplings cannot be applied due to ethical, technical and cost reasons,…
Read moreA simple physiological-pharmacokinetic model to simulate bioequivalence trials
Thursday 16 October, 2025
The analyte to be evaluated in bioequivalence trials is still today a controversial issue. The objective of this work is…
Read moreClinical Trial Simulation of the Dose-Response Relationship of a Direct Thrombin Inhibitor, Dabigatran Etexilate, in Hip Replacement Patients
Thursday 16 October, 2025
Objectives: To estimate the posterior distribution of the maximum response (Rmax), the minimum response (Rmin), and the area under the…
Read moreSAEM in MATLAB: an alternative to linearization
Thursday 16 October, 2025
Stochastic Approximation EM (SAEM) is a powerful algorithm for maximum likelihood estimation in nonlinear mixed effects models [1-4]. This algorithm…
Read moreEstimation of population pharmacokinetic parameters of saquinavir in HIV patients and covariate analysis with MONOLIX
Thursday 16 October, 2025
PDF of poster Context: We developed the software MONOLIX which implements an algorithm for maximum likelihood estimation in nonlinear mixed…
Read morePopulation Analysis of the Pharmacokinetics and the Haematological Toxicity of the Fluorouracil-Epirubicin-Cyclophosphamide Regimen in Breast Cancer Patients
Thursday 16 October, 2025
Objectives: The aims of the study were (i) to characterise the pharmacokinetics (PK), including inter-individual and inter-occasion variability as well…
Read moreOptimising PK sampling under the constraint imposed in later phase clinical trials
Thursday 16 October, 2025
PDF of poster Objectives: When collecting pharmacokinetic (PK) data in a clinical trial an important design factor is the number…
Read morePotential consequences of drug non-compliance on the therapeutic / iatrogenic effects of oral anticoagulant therapy : an in silico study.
Thursday 16 October, 2025
Objectives: In relation to their narrow therapeutic index, oral anticoagulant agents are often under prescribed, too low doses leading to…
Read more