Thursday 16 October, 2025
Objectives: The goals of this analysis were to develop a population pharmacokinetic/pharmacodynamic model that describes the relationship between patient exposure…
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Population pharmacokinetic modelling of gentamicin and vancomycin in patients with unstable renal function following cardiothoracic surgery
Thursday 16 October, 2025
PDF of poster Objectives: To describe the population pharmacokinetics (PopPK) of gentamicin and vancomycin in cardiothoracic surgery patients with changing…
Read morePharmacodynamic drug interaction of roxifiban during CYP induction and inhibition
Thursday 16 October, 2025
Objective: To investigate the cytochrome P450-modulated effects on the pharmacokinetics and pharmacodynamics of the active hydrolysis metabolite of roxifiban, XV459,…
Read moreAn example of application of the population approach to toxicological studies.
Thursday 16 October, 2025
PDF of poster Usually, pharmacokinetic information is obtained from satellite groups of animals during toxicological studies. This approach provides a…
Read moreThe cytochrome P450 3AP1 variant genotype shows correlation with the true clearance in a renal transplant population
Thursday 16 October, 2025
PDF of poster Background. Cytochrome P450 3AP1 is important for the metabolism of sirolimus (SRL). Polymorphisms in the gene affect…
Read moreInfluence of high levels of alpha-1-acid glycoprotein in the pharmacokinetics and the analgesic effect of methadone in the rat: A population approach
Thursday 16 October, 2025
Background: The pharmacokinetics (PK) and pharmacodynamics (PD) of methadone (M), an opiate agonist, shows still unclarified inter-individual variability [1]. M…
Read moreAltered effect and pharmacokinetics of propofol in rats with experimental diabetes mellitus
Thursday 16 October, 2025
Background: Propofol shows large variability in the hypnotic dose that may be due to pharmacokinetic and/or pharmacodynamic alterations caused by…
Read moreIdentifying and minimizing major sources of variability in population pharmacokinetic studies
Thursday 16 October, 2025
PDF of poster Objectives: Occasional sampling of the concentrations of drug in plasma is used to study the pharmacokinetics of…
Read moreStrategies to Improve Model-based Decision-making During Clinical Development
Thursday 16 October, 2025
PDF of poster Objectives: To assess the utility of a novel PK/PD-based modeling and simulation strategy as well as the…
Read moreA Deconvolution Method for Linear and Nonlinear Systems based on Stochastic Differential Equations
Thursday 16 October, 2025
PDF of poster Objectives: The objective of this contribution is to demonstrate the performance of a new deconvolution method based…
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