Thursday 16 October, 2025
Aim: The likelihood ratio test is commonly used as a tool for judging statistical significance of covariate relationships when building…
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Population pharmacodynamic model for count data: Application to clinical trial simulations for compound PH2000 for the improvement of the number of satisfying events.
Thursday 16 October, 2025
The investigational compound PH2000*, active in the neurohormonal-gut axis, is claimed to improve the number of satisfying events (SEs) in…
Read moreEffect of Quinidine on the Pharmacokinetics and Pharmacodynamics of a CYP2D6 substrate (S-YYYY) via mixed-effect modelling
Thursday 16 October, 2025
Objectives: The purpose of this study was to evaluate the effect of Quinidine administration on the pharmacokinetics and the pharmacodynamics…
Read moreWhen baseline matters. The presence of bias and inaccuracy in population parameter estimates derived from
Thursday 16 October, 2025
Assessment of treatment effect and its correlation to drug concentration and dosing regimen are major endpoints in clinical drug developm…
Read moreComparison of covariate models for Bayesian posterior pharmacokinetic parameter estimates from NONMEM with those from a n onparametric approach: Application to levofloxacin.
Thursday 16 October, 2025
The population pharmacokinetics (PK) of the l-enantiomer of ofloxacin (levofloxacin) (data published in Preston e t al., Antimicrob. Agents Chemother.,…
Read moreAnalysis Of 5-Fu And Three Metabolites Concentration In Plasma Cancer Patients By Bayesian Autoclassificatio N Method.
Thursday 16 October, 2025
5-Fluorouracil (5-FU) is a commonly used anticancer agent for treatment of solid tumours. Certain studies have reported c onflicting results…
Read moreLearnings from a Population Pharmacokinetic Substudy of a Large Phase III Trial
Thursday 16 October, 2025
Sodium-proton-exchange inhibition is a promising novel approach to achieve cardioprotection in patients at risk of myocar dial necrosis. A large…
Read morePopulation Pharmacokinetics of Mefloquine in patients with acute falciparum malaria
Thursday 16 October, 2025
Mefloquine is the treatment of choice for multi-drug resistant falciparum malaria. The factors which influence the pharmacokinetic properties of mefloquine…
Read moreAn approach to non-linear kinetics using first-order characteristics
Thursday 16 October, 2025
It is often assumed that all kinetics of a dynamic system are of first-order. This assumption allows for an easy…
Read moreAn approach to non-linear kinetics using first-order characteristics
Thursday 16 October, 2025
It is often assumed that all kinetics of a dynamic system are of first-order. This assumption allows for an easy…
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