Thursday 16 October, 2025
From a data analyst point of view, the majority of the time in a population analysis using NONMEM, is spent…
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Pharmacokinetics of Daunorubicin after Application of Liposomal Daunorubicin (Daunoxome®) in Children
Thursday 16 October, 2025
Daunorubicin is an important part of many treatment protocols in pediatric oncology. In an attempt to reduce the serious cardiotoxic…
Read moreImpact Of Model Linearization On The Accuracy Of Population Information Matrix And Optimal Design
Thursday 16 October, 2025
Suitable scalar functions of the population information matrix can be used as design criteria when optimizing an experiment for estimating…
Read moreSemi-Parametric Approach To Describe Hydromorphone Plasma Concentrations After The Administration Of Immediate And Controlled-Release Formulations
Thursday 16 October, 2025
Hydromorphone is a semi-synthetic opioid used in the treatment of moderate to severe pain. Its short elimination half-life makes it…
Read moreEvaluation of tests based on individual versus population modelling to compare dissolution curves
Thursday 16 October, 2025
Our study was motivated by the analysis of dissolution tests performed For several batches of a long-acting repeatable formulation of…
Read moreCardiovascular Safety Data Analysis via Mixed-Effects Modelling
Thursday 16 October, 2025
Many drugs prolong QT intervals on electrocardiogram (ECG) that may cause serious problems, and may lead to ‘torsades de points’…
Read moreSeparating Responders and Non-responders Using A Mixture of Distributions: An Example of Count Response
Thursday 16 October, 2025
A patient population is usually heterogeneous with respect to response to drug therapy. In any clinical efficacy trial there are…
Read morePopulation Pharmacokinetics of the Low-Efficacy Opioid receptor Agonists: Butorphanol and Nalbuphine
Thursday 16 October, 2025
Aim: The aim of this study was to investigate the in vivo pharmacokinetics (pk) of low-efficacy -opioid receptor agonists, butorphanol…
Read morePopulation Pharmacokinetics of Gentamicin in Neonates
Thursday 16 October, 2025
Aim: The aim of this study was to develop a population pharmacokinetic model for gentamicin in neonates with emphasis in…
Read morePopulation pharmacokinetic analysis of recombinant human Chorionic Gonadotrophin (Ovidrel) compared with that of urinary human Chorionic Gonadotrophin (Profasi) in women undergoing superovulation
Thursday 16 October, 2025
INTRODUCTION Human Chorionic Gonadotrophin is a hormonal preparation either extracted from the urine of pregnant women (u-hCG – Profasi) or…
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