Thursday 16 October, 2025
Zipped PDF of poster Osteoporosis is a disease characterized by low bone mass and deterioration of bone tissue. This leads…
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Clock time as a control variable for gall bladder emptying in an enterohepatic circulation model
Thursday 16 October, 2025
PDF of poster Objectives & Background: Plasma concentration-time profiles of a drug in clinical development showed multiple peak phenomenon as…
Read moreA new CNS active drug and its metabolite: a population pharmacokinetic analysis
Thursday 16 October, 2025
PDF of poster Objectives & Background: A population pharmacokinetic (PK) model for a new CNS active drug in clinical development…
Read moreAssessment of the potency of a metabolite relative to the parent compound using a population PK/PD model for the inhibition of a neurotransmitter re-uptake transporter in mice
Thursday 16 October, 2025
PDF of poster Objectives & Background: Drug X is a new CNS active compound which is currently under clinical development….
Read moreA physiology based model for the glucose-insulin regulation in healthy volunteers and diabetic patients following intravenous glucose provocations.
Thursday 16 October, 2025
PDF of poster Objectives: The aim of this project was to develop a physiology based model to simultaneously describe the…
Read moreNon-Linear Mixed Effects Models with Stochastic Differential Equations – Implementation of an Estimation Algorithm
Thursday 16 October, 2025
PDF of poster Objectives: Stochastic Differential Equations (SDEs) could potentially aid some parts of PK/PD modelling by better parameter estimates,…
Read morePopulation Pharmacokinetic Model for Cremophor EL
Thursday 16 October, 2025
PDF of poster Objectives: The pharmacologically active micelle-forming vehicle Cremophor EL (CrEL) has been shown to affect the pharmacokinetics of…
Read moreA Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model for Antibiotics
Thursday 16 October, 2025
Objectives: In vitro time-kill studies are commonly used in the assessment of efficacy of antimicrobial agents. The aim of the…
Read moreMechanistic PK/PD modelling for signal transduction modulators. Application to TGF-beta RI antagonists.
Thursday 16 October, 2025
Objectives: To develop a mechanistic PK/PD Model for a new Type I Receptor TGF-b Kinase Inhibitor using human xenografts. Methods:…
Read moreComparison of different models to describe simultaneously the kinetics of parent drug and metabolites after oral administration.
Thursday 16 October, 2025
Zipped PDF of poster Introduction: The two most popular models used to fit drug and metabolite kinetics are: Model I,…
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