Thursday 16 October, 2025
Aim: The aim of the present analysis was to characterize the relationship between the plasma concentration of inogatran, a synthetic…
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Population PK/PD Modelling of Moxonidine in Hypertensive Patients using Manual and 24h-Ambulatory Blood Pressure Data
Thursday 16 October, 2025
Although the PK/PD analysis of blood pressure has been reported on several occasions, the models developed did not take into…
Read moreComparison of Model Dependent and Independent Population Pharmacokinetic Analyses
Thursday 16 October, 2025
Model based approaches such as nonlinear mixed effect modelling (NONMEM) can be a time consuming and expensive process as it…
Read morePopulation Pharmacokinetic Analysis of Mizolastine in Children 6 to 12 Years Old using NONMEM
Thursday 16 October, 2025
The pharmacokinetic profile of mizolastine, a second generation antihistamine agent, was assessed in children aged from 6 to 12 years…
Read moreEnterohepatic circulation model for population pharmacokinetic analysis
Thursday 16 October, 2025
Entero-hepatic circulation may affect the terminal half-life, the area under the plasma concentration-time course and bioavailability. Although several pharmacokinetic models…
Read morePopulation Pharmacokinetics of Tacrolimus in Pediatric Liver Transplant Patients under Rescue Therapy
Thursday 16 October, 2025
Tacrolimus (FK) can be used as rescue therapy for reversal of acute or chronic rejection and CsA toxicity, representing a…
Read moreCapecitabine Population Pharmacokinetics of Combined Sparse Data from Phase II Breast Cancer Patients and Extensive Data from a Bioequivalence Study
Thursday 16 October, 2025
XELODAä (capecitabine) is a novel fluoropyrimidine carbamate for oral treatment of solid tumors. It is extensively absorbed and metabolized in…
Read moreA Population Model for Compliance and Drop-out Model for Once a Day Regimen in Depressed Patients
Thursday 16 October, 2025
Drug taking behavior is traditionally decomposed in 2 dimensions: accuracy (taking at scheduled times) and compliance (taking at the prescribed…
Read moreComparison of Three Methods to Analyse the Population Pharmacokinetics of High-Dose Carboplatin in Patients with Testicular Carcinoma
Thursday 16 October, 2025
Introduction: Carboplatin is a widely used cytotoxic agent showing activity against several solid tumours. To reduce the variability in the…
Read moreApplying a Population Model to Physiologically Based Modeling of Human Exposure to Dichloromethane Vapor using Markov Chain Monte Carlo Simulations
Thursday 16 October, 2025
Physiologically based toxicokinetic (PBTK) models are routinely used to assess the kinetics of volatile substances. However, such modeling is often…
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