Thursday 16 October, 2025
Introduction: Drugs mainly eliminated by renal excretion are usually dose adjusted based on creatinine clearance (CLcr). The crucial questions in…
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Likelihood-based Diagnostics for Influential Individuals in Non-Linear Mixed Effects Model Selection
Thursday 16 October, 2025
Purpose: Data from single individuals, or a small group of subjects may influence non-linear mixed effects model selection. Diagnostics routinely…
Read moreStudy of the Digoxin-Acenocoumarol Interaction in Patients using Population Pharmacokinetics
Thursday 16 October, 2025
The objective of the study has been to evaluate the interaction between Digoxin and Acenocoumarol using population pharmacokinetics. The study…
Read morePopulation Pharmacokinetics of High Dose of Cyclophosphamide in High Risk Breast Cancer Patients
Thursday 16 October, 2025
Background: High dose chemotherapy (HDCT) and peripheral blood stem cell transplantation (PBSCT) is a therapeutic strategy that seems improve disease…
Read morePK/PD Modelling: The Problem Of Chance Correlations In Population Pharmacokinetics
Thursday 16 October, 2025
An important step in PK/PD modelling is the identification of descriptors accounting for the intersubject variability of pharmacokinetic parameter estimates….
Read moreConstructing a Prediction Interval for Time to Reach a Threshold Concentration Based on a Population Pharmacokinetic Analysis: an Application to Basiliximab in Renal Transplantation
Thursday 16 October, 2025
Basiliximab is an immunosuppressant chimeric monoclonal antibody directed to the human interleukin-2 receptor, a -chain used for prevention of acute…
Read morePopulation Analysis of Pediatric Pharmacokinetic Data of Netilmicin Accounting for Dilution Errors Before Infusion
Thursday 16 October, 2025
For many drugs intravenously given to infants and neonates dilution procedures have to be performed before the infusion resulting in…
Read morePopulation Pharmacokinetics of Oral Gancyclovir In 42 HIV-Infected Patients With and Without Diarrhea
Thursday 16 October, 2025
Oral gancyclovir is a poorly absorbed antiviral drug (F ~ 6-9%). It is used in cytomegalovirus infection prophylaxis during HIV…
Read moreMeta-Analysis of the Exposure/Efficacy Relationship for Sumatriptan Nasal Spray
Thursday 16 October, 2025
This study is a population PK/PD meta-analysis of five clinical studies where Sumatriptan nasal spray was administered to patients during…
Read moreThe impact of Compliance in Population Pharmacokinetic (PK)/ Pharmacodynamic (PD) Modeling
Thursday 16 October, 2025
In population PK/PD studies, one observes just a few concentration/effect measures spread out in time, on a sizable sample of…
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