Thursday 16 October, 2025
Tacrolimus is an immunosuppressive agent who presents great intraindividual and interindividual variability. The goal of the present population PK analysis…
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Bayesian Monitoring of Vancomycin Concentrations in Newborns: Choice of the Optimal Covariate of Elimination
Thursday 16 October, 2025
Vancomycin dosage regimens were routinely adapted in new borns by the pharmacist staff of Debrousse hospital with USCPACK PC clinical…
Read moreA Pharmacokinetic Model for Alpha Interferon Administered Subcutaneously
Thursday 16 October, 2025
Aims: To model the pharmacokinetic profiles of alpha 2b interferon (aIFN) after a single subcutaneous (s.c.) injection of 3 million…
Read morePopulation pharmacokinetic in ambulatory new-borns treated with long elimination half-time drugs for chronic asymptomatic infectious disease. Which blood sampling design and data collection process to adopt ?
Thursday 16 October, 2025
Context: No well-controlled clinical trials have been done to assess oral therapy efficacy and safety in new-borns with congenital toxoplasmosis….
Read moreInfluence of Errors in Data Collection on Estimated Population Pharmacokinetic Parameter Values and Proposed a Priori Dosage Regimen
Thursday 16 October, 2025
Objectives: Influence of quality data collected for TDM (administered doses, AD; infusion duration, ID; blood sampling time, BST) has already…
Read moreSimulation, a Tool for Designing the Suitable Formulation: Example of S 18326
Thursday 16 October, 2025
Background: S 18326 is a potent and selective direct thrombin inhibitor proposed as anti-thrombotic agent. S 18326 has been administered…
Read morePharmacokinetic modeling of tobramycin in neonates: a comparison of NONMEM and NPEM2
Thursday 16 October, 2025
Introduction: Nonlinear mixed effect modeling (NONMEM) and nonparametric expectation maximization (NPEM) have both been used in population pharmacokinetic modeling of…
Read morePopulation Pharmacokinetic And Pharmacodynamic Of Cyclophosphamide In Breast Cancer.
Thursday 16 October, 2025
BACKGROUND: Time to hematologic recovery after mieloablative chemotherapy and peripheral blood stem-cell support is an important clinical outcome in breast…
Read moreKinetic behaviour of digoxin in a paediatric population
Thursday 16 October, 2025
Some changes on digoxin disposition appear to be strongly correlated with normal physiological development during the first year of life….
Read morePopulation Pharmacokinetics Of Ropivacaine Injected Caudally In Infants And Children
Thursday 16 October, 2025
Ropivacaine (R) is a new local anaesthetic agent. This drug is injected in the epidural space (extravascular injection) of children…
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