Thursday 16 October, 2025
Objective To establish a pharmacokinetic-pharmacodynamic model for interferon alpha-2b (Intron A) and its clinical endpoints in hepatitis-C patients. Methods Despite…
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Application of Dose Response Modeling to anti-Rheumatic Leflunomide Therapy
Thursday 16 October, 2025
Introduction: The novel disease-modifying antirheumatic drug (DMARD) leflunomide has shown efficacy in rheumatoid arthritis. Leflunomide’s active metabolite, A77 1726 (M1),…
Read morePopulation Pharmacokinetic Approach to Compare Oral and IV Administration of Etoposide
Thursday 16 October, 2025
Introduction: Etoposide acts by inhibition of topoisomerase II, and marked schedule-dependency has been demonstrated. Antitumour effect may be related to…
Read moreForecast the minimal effective dose in man using receptor occupancy evaluated in preclinical PET experiments, Clinical Trial Simulation and Dose-to-Event probabilistic model
Thursday 16 October, 2025
Preclinical studies have been conducted on a new compound explored in neurological and psychiatric disorders including pain. A PK/PD model…
Read morePopulation Pharmacokinetics Of Intravenous Magnesium Sulphate In Preeclamptic Patients
Thursday 16 October, 2025
AIM: To determine the population pharmacokinetics (PK) of magnesium sulphate (Mg) in the perinatal period from sparse observational data in…
Read moreSimulation-Revealed Bias In Dose-Response Relationships Obtained From Titration Trials
Thursday 16 October, 2025
Objective: To assess the potential for bias in dose-response relationships obtained from titration trials. Methods: Using an Emax pharmacodynamic model,…
Read moreEstimation of Exact Significance Levels during Nonlinear Mixed Effects Model Building: Some Inferences
Thursday 16 October, 2025
Introduction: One of the main objectives of the nonlinear mixed effects modeling is to provide rationale individualized dosing strategies, by…
Read moreA Bayesian analysis of halofantrine pharmacokinetics in malaria patients
Thursday 16 October, 2025
The purpose of the current study was to investigate a Bayesian approach to propagate pharmacokinetic information from a normal volunteer…
Read moreAssessing the Magnitude of Enterohepatic Recirculation of Ezetimibe using a Population Pharmacokinetic Model
Thursday 16 October, 2025
Purpose. To develop a population pharmacokinetic (PPK) model encompassing enterohepatic recirculation (EHC (1)). Methods. Ezetimibe is an azetidinone inhibitor of…
Read morePharmacokinetics of morphine in CSF- Modelling a kinetically invisible distributional space.
Thursday 16 October, 2025
The population pharmacokinetics of morphine were investigated in a group of eight patients. An intravenous infusion of 0.5mg/kg morphine sulfate…
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