Thursday 16 October, 2025
There has been a growing interest in the possibility of predicting in vivo drug-drug interactions from in vitro data during…
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Integrated mathematical modeling of lipolysis
Thursday 16 October, 2025
Metabolic substrate fluxes are generally estimated using the stable isotope method, where rates of appearance (Ra) are calculated using Steele’s…
Read moreNew Advances in Nonparametric PK/PD Population Modeling
Thursday 16 October, 2025
The nonparametric (NP) maximum likelihood (ML) method of PK/PD population modeling has several advantages relative to parametric approaches, notably the…
Read morePK/PD of the Epirubicin-Docetaxel therapy in breast cancer patients.
Thursday 16 October, 2025
The effectivity of the anthracycline epirubicin and the taxane docetaxel when given as single drugs has resulted in the introduction…
Read morePopulation pharmacokinetic parameter estimation to assess the impact of dose on etoposide pharmacokinetics
Thursday 16 October, 2025
Objectives: To perform a population pharmacokinetic study in order to evaluate the effect of dose and various patient specific factors…
Read morePharmacodynamic modelling of sedation and respiratory effects of propofol in Parkinson disease patients undergoing functional stereotactic surgery
Thursday 16 October, 2025
Population pharmacokinetic/pharmacodynamic modelling approach was used to characterize the sedation and airway obstruction effects of propofol administered in a target…
Read morePopulation Pharmacokinetic Analysis Of Aripiprazole
Thursday 16 October, 2025
Aripiprazole, a quinolinone derivative, is being developed as a novel antipsychotic agent. It has a mode of action that differs…
Read morePopulation pharmacokinetic scaling up from animal to patient of a novel anti-cancer drug (vinflunine): a tool to predict the maximum tolerated dose in early clinical trial.
Thursday 16 October, 2025
Vinflunine is a third generation of semisynthetic vinca alkaloids: two flurine atoms were introduced in the molecule thanks to super-acid…
Read moreAdaptation of Gauss Hermite Quadrature to Estimate Population Parameters in Mixed Models: Application to the Detection of Subpopulations
Thursday 16 October, 2025
Several methods have been proposed in Pharmacokinetic/Pharmacodynamic population modelling for estimating random and fixed parameters in mixed models. Among non-bayesian…
Read moreMixed-effects modelling of the time-course of total and unbound plasma concentration for the anti rheumatoid arthritis agent Ro 32-3555
Thursday 16 October, 2025
Objectives A mathematical pharmacokinetic model was developed for the description and prediction of the time-course of total and unbound plasma…
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