Thursday 16 October, 2025
Population pharmacokinetics of recombinant human luteinising hormone (r-hLH) was investi- gated during a four-arm phase II trial, during which r-hLH…
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Therapeutic Drug Monitoring Of Antiepileptic Drugs; Can We Use TDM Data To Estimate Population Pharmacokinetic Parameters?
Thursday 16 October, 2025
The wide use of TDM in optimizing the treatment of epilepsy has generated a huge body of data on the…
Read moreA Bootstrap Algorithm For Confidence Limits For Nonparametric Population Models
Thursday 16 October, 2025
Until now, estimates obtained in nonparametric population (NP) analyses have not included confidence intervals. To remedy this situation, we have…
Read morePopulation Pharmacokinetic / Dynamic Modeling Via The World Wide Web
Thursday 16 October, 2025
A new research resource has been developed, allowing organizations with limited resources for program development to develop large and nonlinear…
Read moreAn Npem Population Analysis Of Ciclosporine – Modelling Oral Drug Absorption As A Time-Dependent Function
Thursday 16 October, 2025
Ciclosporine – A (CYA) is, despite being one of the drugs. most widely subjected to therapeutic drug monitoring, still a…
Read morePopulation Pharmacokinetic Analysis Of Mizolastine In Children 2 To 5 Years Old Using NONMEM
Thursday 16 October, 2025
The pharmacokinetic profile of mizolastine, a second generation antihistamine agent, was assessed in children aged from 2 to 5 years…
Read morePopulation time dependent pharmacokinetics of cyclosporine in renal transplant patients
Thursday 16 October, 2025
Immunosuppression with cyclosporine A has proven successful in preventing allograft rejection. However during the first months, twice daily cyclosporine oral…
Read moreHigh-Performance Computing In PK/PD – Parallel Execution Of NONMEM Runs On A Linux Cluster
Thursday 16 October, 2025
A number of computer intensive statistical methods have recently gained attention in the PK/PD research community (as judged by for…
Read moreA semi-physiological model for the pharmacodynamic interaction on leukocytes after 5-fluorouracil and epirubicin administration
Thursday 16 October, 2025
Aim: To develop a pharmacokinetic-pharmacodynamic model for leukocyte toxicity after administration of 5-fluorouracil and epirubicin in combination in rats. Methods:…
Read morePK/PD Modelling O of Antidiuretic Effect of Desmopressin (dDAVP) After Oral Administration in Elderly Men in a Phase II Study Using NONMEM
Thursday 16 October, 2025
Background: Desmopressin (dDAVP) is a nonapeptide analogue of the antidiuretic hormone (ADH). In reference to previous studies the PK of…
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