Thursday 16 October, 2025
Efficacy/safety trials are usually longitudinal, and the response is measured several times in each patient. We suggest a generic dynamic…
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Erythropoietin Dosage Individualisation In Anemic Patients With Chronic Renal Failure.
Thursday 16 October, 2025
Introduction. Secondary anemia associated with the chronic renal failure (CRF) is a common clinical situation in patients who are receiving…
Read moreCross Model Validation As A Tool For Population Pharmacokinetic/Pharmacodynamic Covariate Model Building
Thursday 16 October, 2025
One important part of population pharmacokinetic/pharmacodynamic analysis (pop-PK/PD) is the covariate model building, i.e. the identification of patient specific characteristics…
Read moreAn Example Of A Neural Network Like A Pharmacokinetic/Pharmacodynamic Model.
Thursday 16 October, 2025
Introduction. This work presents a novel approach to obtain pharmacokinetic/pharmacodynamic (PK/PD) model. Neural networks are non lineal models, and present…
Read moreComparative study of NONMEM and Neural Networks for Cyclosporine Dosage Prediction in Renal Allograft Recipients
Thursday 16 October, 2025
Purpose: The objective of the present study was to build accurate models in order to determine the next dosage of…
Read morePopulational phamarmacokinetic of cyclosporin in renal transplantation
Thursday 16 October, 2025
Cyclosporin is a imunosupressor widely used in renal transplantation in order to prevent halograph rejection. The inter and intra-individual variability…
Read morePopulation Pharmacokinetic Model For Cyclophosphamide Autoinduction In Breast Cancer Patients
Thursday 16 October, 2025
BACKGROUND. Cyclophosphamide (CP) is most commonly used in high dose chemotherapy (HDCT) prior to peripheral blood stem cell transplantation (PBSCT)…
Read morePopulation Pharmacokinetics of Gancyclovir Applicated in Newborns and Infants with Congenital Symptomatic Cytomegaly
Thursday 16 October, 2025
Introduction: Gancyclovir (GCV) is drug of choice for the treatment of active cytomegalovirus infection in newborns and infants. There are…
Read morePopulation PD and Clinical Trial Simulation: Investigating Oral Dosing Regimens for a new Bisphosphonate Drug for Treatment of Osteoporosis
Thursday 16 October, 2025
Ibandronate (IBN), a nitrogen-containing bisphosphonate, is under investigation in both oral and intravenous formulations for treatment and prevention of postmenopausal…
Read morePopulation Pharmacokinetics of Ibandronate in Caucasian and Japanese Post-Menopausal Women.
Thursday 16 October, 2025
Introduction & Objectives Ibandronate is a high potency amino-bisphosphonate in Phase III development for osteoporosis. This class of drugs is…
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