Thursday 16 October, 2025
*We have now extended our nonparametric EM (NPEM) PC software to include nonlinear systems, incorporating a differential equation (DE) solver…
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Modelling interoccasion variability after repeated oral drug administration.
Thursday 16 October, 2025
The population pharmacokinetics of compound T was investigated in a sample of 40 individuals of both gender. Drug administration was…
Read moreA population approach to the study of structure-pharmacokinetic relationships: An example with a homologous series of barbiturates
Thursday 16 October, 2025
Based on a set of experimental data, including the temporal profiles of a homologous series of 9 barbituric acids in…
Read moreAssessment Of Two Strategies For Detecting Pharmacodynamic Interactions In The Context Of The NPMLApproach;
Thursday 16 October, 2025
Population approaches are appealing methods for detecting drug-drug interactions in case of sparse data, however they sometime fail to reveal…
Read moreEvaluation of the dose / concentration / response relationship of an antithrombotic acting development drug, performed with NONMEM and P – PHARM
Thursday 16 October, 2025
The aim of pharmacokinetic (pk) evaluation is to identify key characteristics of a drug, which allow the characterisation and prediction…
Read moreA Stepwise Procedure For Interindividual Variability Model Building
Thursday 16 October, 2025
In many population pharmacokinetic and pharmacodynamic studies the aim is to quantify interindividual variability. This variability is partly explained by…
Read moreComputer Simulation: A Useful Tool for Trial Dosage Selection
Thursday 16 October, 2025
Introduction: There is often limited data, and thus great risk, in choosing a specific dose for a pivotal efficacy trial….
Read morePopulation Pharmacokinetics Of Amikacin In Hematologic Malignant Patients
Thursday 16 October, 2025
The aim of this study was to analyze the pharmacokinetic behaviour of amikacin in hematologic malignant patients using a mixed-effect…
Read moreIndirect Pharmacodynamic Model With Two Different Markers Of Oral Anticoagulant In Young Healthy Volunteers
Thursday 16 October, 2025
The pharmacodynamic marker generally used for adaptative control of oral anticoagulant was the Prothrombin Time (PT). But a more direct…
Read moreOptimization Of A Population Pharmacokinetic Model Of Theophylline In Adult Patients
Thursday 16 October, 2025
Non linear Mixed Effects Modelling (NONMEM) was used to estimate Theophylline population pharmacokinetic parameters values in a group of adult…
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