M. Van Guilder(1), R. Leary(2), A. Schumitzky(1), X.Wang(1), S. Vinks(3), and R. Jelliffe(1).
1=Laboratory of Applied Pharmacokinetics, USC School of Medicine, Los Angeles CA, USA, 2=San Diego Supercomputer Center, San Diego CA, USA, 3=The Hague Hospitals Central Pharmacy, The Hague, The Netherlands.
*We have now extended our nonparametric EM (NPEM) PC software to include nonlinear systems, incorporating a differential equation (DE) solver and implementing parallelization. The user enters the DE’s on the PC, and runs another PC program to enter the instructions for the SDSC Cray T3E, and to specify the subject data files. *The user then FTP’s the source code DE’s, and the instructions and subject data files to the Cray, Telnets in, compiles and links the DE source code, and then runs the program. Speedup is 24-fold for 32 nodes. Using 8 nodes, a 5 parameter Michaelis-Menten NPEM model of pipericillin, using 80,000 grid points for the joint density function, took 1/2 hour. The user then FTP’s the result files back to his/her PC and examines them with local software and plots. *This software has now become a research resource for such modeling. The available grid points have now been increased to 8,000,000. We plan to make the resource available over the web. (Supported by US NIH grant RR11526).
Reference: PAGE 7 (1998) Abstr 287 [www.page-meeting.org/?abstract=287]
Poster: poster