Thursday 16 October, 2025
Objectives: The pharmacokinetics of Drug A were determined in 39 healthy women during a treatment period of three to six…
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The use of Population Pharmacokinetic Approaches to Aid in the Assessment of Bioequivalence for a Highly Variable Drug
Thursday 16 October, 2025
A highly variable drug has been defined as one with an intra-subject CV of 25-30% or greater (Eur J of…
Read moreNONMEM in Destructive Sampling Experiments; Experiences with the Toxicokinetics of Dibromchloromethane
Thursday 16 October, 2025
Destructive sampling (DS) is frequently used to yield data from animals in pharmacokinetic experiments. The assumption made in such experiments…
Read moreApache II as Predictor of Gentamicin Pharmacokinetic Parameters in Critical Ill Patients
Thursday 16 October, 2025
INTRODUCTION Today, gentamicin (GENT) is still used in serious infections in the critical ill patients. To produce efficacious and safe…
Read moreSufentanyl Pharmacokinetic-Pharmacodynamic Modelling (PK/PD) on NONMEM in 10 Patients with Coronary Surgery
Thursday 16 October, 2025
10 patients were investigated. Their average characteristics are: age 658.7 years, weight 75.79.9 kg. They were given an average total…
Read morePopulation Distribution of Platinum Pharmacokinetic Parameters for Dosage Recommendations of CDDP and Adaptive Control during the Course of Therapy, using different Softwares.
Thursday 16 October, 2025
This study was undertaken in order to make an evaluation of the performance of several softwares for pharmacokinetic parameters predictions…
Read moreHow Many Patients and Blood Levels for Population Pharmacokinetic Analysis? a Study with a One Compartment Model.
Thursday 16 October, 2025
The number of patients (pts) and the number of blood levels (bl) which are appropriate for a pharmacokinetic population analysis…
Read moreEffect Concentration Relationships of Theophylline in Apnoea of Prematurity
Thursday 16 October, 2025
The study aims to investigate the relationship between plasma concentrations of theophylline and its effect on the incidence and duration…
Read moreSampling Strategies for Population Analysis: a Theoretical Study to Support Practical Results Obtained with Caffeine in Premature Neonates
Thursday 16 October, 2025
Population pharmacokinetic analysis is a commonly used tool to analyse routine clinical data. In recent years some work has been…
Read moreNon Linear Pharmacokinetics of Ethanol. Analysis of Patients with NONMEM. Study I
Thursday 16 October, 2025
20 volunteers, male, with the following average characteristics were investigated; age 24.13.57 years, weight 70.78.5 kg, height 178.77.50 cm, body…
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