Thursday 16 October, 2025
Sparse data arising from a population pharmacokinetic study can be analyzed by nonlinear mixed effects models. The most widely used…
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Estimation of Population Pharmacokinetic Parameters of Tobramycin in Intensive Care Unit Patients Using Different Programs
Thursday 16 October, 2025
Aminoglycoside (AMG) antibiotics are used in prophylaxis and treatment of serious infections in the intensive care units (ICU). Many physicians…
Read moreEvaluation Of Bayesian Estimators For Adaptative Control Of Vancomycin Built With Two Methods Of Population Modeling
Thursday 16 October, 2025
The aim of this study is to constitute two Bayesian estimators. For adaptative control of Vancomycin from the same population…
Read morePopulation pharmacokinetics of nortriptyline at monotherapy and during concomitant treatment with drugs that inhibit CYP2D6; an evaluation with the nonparametric maximum likelihood method
Thursday 16 October, 2025
Therapeutic drug monitoring data of nortriptyline (NT) were evaluated with the nonparametric maximum likelihood method (NPML) in order to determine…
Read moreNon-Parametric Density Estimation Applied To Population Studies
Thursday 16 October, 2025
The aim of a population Study [1] is to describe the variability and to detect particular subsets by establishing the…
Read moreInformation Theory in Drug Development. Applications to a new antidepressant.
Thursday 16 October, 2025
The aim of the study was to assess the inter-individual variability of F2207, a new antidepressant drug with an original…
Read moreCyclosporine Population Pharmacokinetic Parameters In The Early Postoperative Hepatic Transplantation Phase: Preliminary Results
Thursday 16 October, 2025
Objective: The purpose of the present study was to estimate the variability of cyclosporine pharmacokinetic parameters (slope of volume to…
Read moreCovariate Identification for Population Pharmacokinetic Modelling
Thursday 16 October, 2025
Explaining and quantifying the variability in response to drugs is an important step in producing efficacious and safe dosage regimens….
Read morePopulation analysis of a dose ranging study
Thursday 16 October, 2025
In an important paper Sheiner et al discussed clinical trials design for dose ranging studies. It is the aim of this…
Read morePharmacokinetics of Meropenem in pediatrics – NONMEM analysis
Thursday 16 October, 2025
Introduction: Meropenem is a broad spectrum carbapenem antibiotic which is likely to be useful in children. Aims: To estimate population…
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