Thursday 16 October, 2025
Midazolam, a watersoluble benzodiazepine with a short half-life, has been used in neonatal intensive care units for several years using…
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The Population Pharmacokinetics of Ondansetron from Phase 1 Studies
Thursday 16 October, 2025
As part of a programme to model the variability of the pharmacokinetics of ondansetron we examined data arising from phase…
Read moreCaffeine Pharmacokinetics In a Pediatric Population
Thursday 16 October, 2025
Neonatal apnea is a common problem: it occurs in 25% of infants under 2500 gr and 80% of infants under…
Read morePharmacokinetics Of S-12024 By A Prospective Population Approach In Phase II.
Thursday 16 October, 2025
S-12024 is an original compound with cognitive enhancing properties in animals. After Phase I studies in healthy volunteers, three Phase…
Read moreA Non-Parametric Population PK/PD Analysis Of Tolcapone To Predict L-Dopa Plasma Concentrations
Thursday 16 October, 2025
Population PK/PD modeling can provide useful insight into the complex input-output relationships of pharmacological and therapeutic processes in naturalistic settings….
Read moreUse of NONMEM to determine the influence of CYP2D6 activity on the pharmacokinetics of amitriptyline and nortriptyline
Thursday 16 October, 2025
Introduction: About 8% of Caucasians have genetic variants of CYP2D6 that express inactive enzyme and are classed as “poor metabolisers”….
Read moreStability Of Covariate Models
Thursday 16 October, 2025
Covariate relationships of population models are usually derived from a set of candidate covariates. Compared to the number of covariates…
Read moreAn Exploratory Population Pharmacokinetic Analysis Examining The Influence Of Demography and Co-Medication On The Plasma Clearance Of The Anti- Epileptic Remacemide.
Thursday 16 October, 2025
Remacemide is in Phase III development for use in the treatment of epilepsy. Both remacemide and its active desglycinyl metabolite…
Read morePK-PD Model Of Ivabradine, A Bradycardic Agent, And Its Metabolite In Healthy Volunteers
Thursday 16 October, 2025
Ivabradine (816257) is a new compound with specific bradycardic action and developed to prevent angina pectoris. In order to establish…
Read morePopulation Pharmacokinetics And Therapeutic Response Of Artemether Following Treatment Of Coartem In Malaria Patients
Thursday 16 October, 2025
Two hundred and sixty patients were enrolled into a randomised, double-blind, parallel group, dose-finding trial of a new antimalarial combination…
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