Thursday 16 October, 2025
Introduction: Aminophylline is used to increase diuresis in critically ill children with fluid overload. ECMO is a life support technique…
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Pharmacokinetic model for vancomycin performed with sparse data on neonates
Thursday 16 October, 2025
Objectives: The marked inter- and intra patient variability of the pharmacokinetics of numerous antibiotics is well known, especially in neonates….
Read morePopulation pharmacokinetics of epirubicin and its main metabolite epirubicinol using NONMEM
Thursday 16 October, 2025
The marked inter- and intrapatient variability of the pharmacokinetics of a number of antineoplastic agents is well known. Moreover, we…
Read moreA Population PK/PD Model for Cortisol Suppression
Thursday 16 October, 2025
Cortisol levels in the plasma follow a circadian variation with its peak in the early morning and a trough in…
Read morePopulation Pharmacokinetics Of Oral Sumatriptan
Thursday 16 October, 2025
Sumatriptan is a highly potent, selective 5-HT1 agonist and is effective in the acute treatment of migraine and cluster headache….
Read moreA Population Approach to Dose Versus Response Relationship For Simvastatin in Hypertensive Hypercholesterolaemic Patients.
Thursday 16 October, 2025
There are many examples of drugs for which clinical exposure leads to a preference for doses which are lower than…
Read moreEffect of covariatcs on steady-state trough plasma bismuth concentrations from GR122311X in duodenal ulcer patients.
Thursday 16 October, 2025
A large clinical trial was carried out which compared the healing and relapse rates after oral dosing with GR122311X (a…
Read moreA Population Pharmacokinetic Study Of Alminoprofen Penetration Into Synovial Fluid
Thursday 16 October, 2025
The pharmacokinetics of alminoprofen in plasma and in synovial fluid was studied in 45 subjects (11 women and 34 men)…
Read moreOptimal Sampling Times Determination By Criteria Incorporating Knowledge Of Parameter Distribution In The Population
Thursday 16 October, 2025
The most common approach to optimize the sampling schedule in parameter estimation experiments is the D-optimality criterion, which consists in…
Read moreComparison of Practical Sampling Strategies for Population Pharmacokinetic Studies
Thursday 16 October, 2025
Population pharmacokinetic analysis is a commonly used tool to analyse routine clinical data. This type of data is characterised by…
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