Thursday 16 October, 2025
Introduction and Objectives: The Gauss Hermite quadrature method allows to get an accurate approximation of the likelihood function by expressing…
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The Visual Predictive Check – Superiority to Standard Diagnostic (Rorschach) Plots
Thursday 16 October, 2025
PDF of poster Objective: NONMEM users typically demonstrate the adequacy of a model by displaying plots of PRED vs DV…
Read moreTopical Corticosteroid Bioequivalence – An Evaluation of the FDA Guidance
Thursday 16 October, 2025
PDF of poster Objective: The US FDA has issued a guidance describing a methodology for the conduct and analysis of…
Read morePopulation Pharmacokinetics of Vancomycin during Extra Corporeal Membrane Oxygenation (ECMO)
Thursday 16 October, 2025
Objectives: Extracorporeal membrane oxygenation (ECMO) is a life support system used in the treatment of severe respiratory or cardiorespiratory failure….
Read morePopulation PK-PD analysis of cardiovascular effects of non-cardiovascular drugs with the emphasis on QT prolongation
Thursday 16 October, 2025
Non-cardiovascular drugs may exhibit effects on biomarkers known as vital signs, like heart rate (HR), blood pressure (BP), electrocadiogram (ECG),…
Read morePopulation pharmacokinetic analysis of concentration data after implantation of sirolimus-eluting Bx Velocity stent in patients
Thursday 16 October, 2025
PDF of poster Objectives: The Bx Velocity, sirolimus-eluting balloon-expandable stent has shown remarkable results in terms of reducing the occurrence…
Read moreIndirect-response model for the analysis of concentration-effect relationships in clinical trials where response variables are scores
Thursday 16 October, 2025
PDF of poster Aim: Clinical effectiveness of many drugs can only be assessed in terms of scores quantifying the patient…
Read moreMixture models : simulation and estimation with NONMEM
Thursday 16 October, 2025
The pharmacokinetic parameters are usually assumed to be normally or log-normally distributed in the population. If a pharmacokinetic parameter is…
Read moreImplications of Including and Excluding Correlation of Random Effects in Hierarchical Mixed Effects Pharmacokinetic Models
Thursday 16 October, 2025
Population modeling is increasingly being employed to make important decisions during drug development. Fundamentally, pharmacokinetic and pharmacodynamic parameters (e.g.: clearance,…
Read moreSimultaneous modelling of disease progression and time to event with NONMEM – likelihood ratio test criteria for random and informative dropout models and an evaluation of two methods affecting the quality of parameter estimates
Thursday 16 October, 2025
PDF of poster Objective: An important challenge for clinical pharmacologists is to be able to describe the time course of…
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