Thursday 16 October, 2025
Purpose: To develop a pharmacokinetic/pharmacodynamic model capable to describe simultaneously and semi mechanistically the time course of the heart rate…
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Population pharmacokinetics of vinflunine from phase I data and evaluation of population sampling designs for further clinical development
Thursday 16 October, 2025
Vinflunine (Javlor(r)) is a novel semi-synthetic vinca alkaloid under development. Vinflunine is administered by short IV infusion and in vitro…
Read moreEvaluation Of An Osteoporosis Biomarker Model For Simulation Using Posterior Predictive Check Technique
Thursday 16 October, 2025
Purpose Osteocalcin (OC) is a biomarker of drug effect on osteoporosis progression. A decrease in OC has been shown to…
Read moreHigh Inter-Patient Variability of Pharmacokinetics of Lamivudine (LMV), Stavudine (STV) and Zidovudine (ZDV) in HIV-Infected Patients treated with HAART (Cophar 1 – ANRS 102 Study).
Thursday 16 October, 2025
Objectives: Little is known about pharmacokinetic (PK) characteristics of combined nucleoside analogs (NA) in patients (pts) treated with HAART. Our…
Read moreEvaluation by simulation of tests based on non-linear mixed-effects models in interaction and bioequivalence cross-over trials
Thursday 16 October, 2025
Objectives : Evaluation of tests based on non linear mixed- effects models (NLMEM) in pharmacokinetic interaction and bioequivalence cross- over…
Read moreComparison between the Fedorov-Wynn algorithm and the Simplex algorithm for population designs optimisation using a model of the HIV viral load decrease
Thursday 16 October, 2025
Context We have recently developed PFIMOPT 1.0 for population designs optimisation . This generic Splus or R function is based…
Read moreDesigns in nonlinear mixed effects models: application to HIV viral load decrease with evaluation, optimization and determination of the power of the test of a treatment effect
Thursday 16 October, 2025
Context: We have proposed Splus and R functions, PFIM and PFIMOPT, for respectively designs evaluation and optimization in nonlinear mixed…
Read moreRelevance of the use of population design evaluation and optimisation methods in the context of drug development projects in Roche
Thursday 16 October, 2025
Context: Population designs evaluation and optimisation methods have been widely developed in the last few years. Based on the population…
Read moreQuantification of 5-HT7 receptor efficacy distribution throughout the canine stomach using the operational model of agonism.
Thursday 16 October, 2025
Objectives This study aimed to determine, quantify and explain regional differences in 5-HT7 receptor efficacy throughout the canine stomach using…
Read moreAgonist-antagonist interaction models with slope factor: implications of an alternative derivation
Thursday 16 October, 2025
Objectives: The method developed by Schild [1] to determine the equilibrium dissociation constant of a competitive antagonist (KB) has been…
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